Dynamic Single-Use Bioreactors Used in Modern Liter- and m3- Scale Biotechnological Processes: Engineering Characteristics and Scaling Up

2013 ◽  
pp. 1-44 ◽  
Author(s):  
Christian Löffelholz ◽  
Stephan C. Kaiser ◽  
Matthias Kraume ◽  
Regine Eibl ◽  
Dieter Eibl
Keyword(s):  
Scaling Up ◽  
Engineering Characteristics ◽  
Single Use ◽  
Biotechnological Processes

Single-Use Technology in Modern Biotechnological Processes

2013 ◽  
Vol 85 (1-2) ◽  
pp. 3-3
Author(s):  
Dieter Eibl ◽  
Regine Eibl
Keyword(s):  
Single Use ◽  
Biotechnological Processes

scholarly journals An overview of drive systems and sealing types in stirred bioreactors used in biotechnological processes

2021 ◽  
Vol 105 (6) ◽  
pp. 2225-2242
Author(s):  
Cedric Schirmer ◽  
Rüdiger W. Maschke ◽  
Ralf Pörtner ◽  
Dieter Eibl
Keyword(s):  
Stirred Tank ◽  
Biotechnological Production ◽  
Comprehensive Overview ◽  
Stirred Tank Bioreactor ◽  
Stirred Bioreactor ◽  
Advantages And Disadvantages ◽  
Type Size ◽  
Single Use ◽  
Biotechnological Processes ◽  
Drive Systems

AbstractNo matter the scale, stirred tank bioreactors are the most commonly used systems in biotechnological production processes. Single-use and reusable systems are supplied by several manufacturers. The type, size, and number of impellers used in these systems have a significant influence on the characteristics and designs of bioreactors. Depending on the desired application, classic shaft-driven systems, bearing-mounted drives, or stirring elements that levitate freely in the vessel may be employed. In systems with drive shafts, process hygiene requirements also affect the type of seal used. For sensitive processes with high hygienic requirements, magnetic-driven stirring systems, which have been the focus of much research in recent years, are recommended. This review provides the reader with an overview of the most common agitation and seal types implemented in stirred bioreactor systems, highlights their advantages and disadvantages, and explains their possible fields of application. Special attention is paid to the development of magnetically driven agitators, which are widely used in reusable systems and are also becoming more and more important in their single-use counterparts.Key Points• Basic design of the most frequently used bioreactor type: the stirred tank bioreactor• Differences in most common seal types in stirred systems and fields of application• Comprehensive overview of commercially available bioreactor seal types• Increased use of magnetically driven agitation systems in single-use bioreactors

International Research-Policy Collaborations for Scaling Up Sustainable Early Development Services

2014 ◽  
Author(s):  
Pia Rebello Britto ◽  
Hirokazu Yoshikawa ◽  
June Lee ◽  
Julieta Trias
Keyword(s):  
Early Development ◽  
International Research ◽  
Research Policy ◽  
Scaling Up

DETERMINATION OF THE TYPE OF A SINGLE-USE GRENADE LAUNCHER BASED ON ITS COMPOSITE PARTS AND FRAGMENTS OF REACTIVE GRENADE FOUND AT THE PLACE OF ACCIDENT

2017 ◽  
Vol 17 ◽  
pp. 245-252
Author(s):  
V. V. Somov
Keyword(s):  
Combustion Chamber ◽  
Structural Features ◽  
Outlet Section ◽  
Technical Expertise ◽  
Jet Engine ◽  
Size Ofthe ◽  
Single Use ◽  
Nozzle Block ◽  
Considerable Damage

In carrying out an investigation into the explosion, among others, the investigative version of the use of a single-use reactive grenade launcher is being considered. The most common for criminal explosions are applied grenade launchers RPG-18, RPG-22, RPG-26. Their use is due to a number of such properties as small size and weight, which makes it possible to transfer them covertly, the range of the shot significantly exceeding the range of the hand grenade throw, the high detonating effect of the rocket grenade explosion. The single-use rocket launchers are generally of the same design. Their differences are in the features of the components construction and dimensional characteristics, which are given in the article. On the basis of expert practice, details ofgrenade launchers that remain at the site of the explosion and have the least damage are determined. These details are the objects of investigation of the explosion technical expertise. These objects include launchers of grenade launchers and rocket parts ofjet grenades. The design features of the launchers, their dimensional characteristics and marking symbols make it possible to determine their belonging to a specific type of jet grenade launchers. Missile parts of jet grenades differ in the form of the combustion chamber of the jet engine, nozzle, in the size ofthe outlet section of the nozzle, in the form and size of the stabilizerfeathers. To determine the belonging of the rocket part of the grenade to a specific type ofjet grenade launcher, it’s necessary to establish a set of structural features and dimensional characteristics. At considerable damage of the combustion chamber of the jet engine, as a rule, the nozzle block remains intact that allows to define diameter of critical section of a nozzle, and on it to establish type of the used single-use grenade launcher.

Track 6.c Introduction: Entrepreneurship in Design Education

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Bryan Howell ◽  
Curt Anderson ◽  
Nile Hatch ◽  
Chia-Chi TENG; ◽  
Neal Bangerter ◽  
...  
Keyword(s):  
Design Education ◽  
Management Strategy ◽  
Business Models ◽  
Scaling Up ◽  
Engineering Management ◽  
Significant Rise ◽  
Limited Resources ◽  
Multidisciplinary Teams ◽  
Interdisciplinary Relationships ◽  
Human Centred Design

Over that last few decades there has been a significant rise in interest for design-led entrepreneurship and innovation. This has brought about the need to expand on the principles and methods of human-centred design by incorporating knowledge from multiple disciplines, such as management, business, and entrepreneurship studies. This expansion aids designers, engineers, and marketing practitioners who strive to create innovative, meaningful and relevant services, business models and experiences. More often than not, ventures operate under very limited resources, and practitioners are often required to fulfil several roles. The concept of ‘multidisciplinary teams’ widely spread in this sphere often bears little resonance in these contexts. Designers possess valuable competencies that can have a significant impact on the venture, especially driving user and context-centred strategy and processes for the introduction, legitimization and scaling-up stages. However, engaging with these areas of practice requires skills and capacities that overlap traditional disciplinary roles. In doing so, the boundaries between design and engineering, branding and communications, cultural and behavioural insight, marketing and management strategy are blurred. As educators in design innovation, how do we explore, define and balance interdisciplinary relationships between design, engineering, management, business and entrepreneurship theories, methods, language and models of education? The purpose of the entrepreneurship in design education track is to discuss methods, models, case studies, research, insights and unexpected knowledge in benefits and limitations of design entrepreneurship education. In particular, the three papers presented in this track demonstrate different approaches to entrepreneurship and design education.

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