Gynecological Malignancies

2016 ◽  
pp. 267-280
Author(s):  
Jennifer Croke ◽  
Eric Leung ◽  
Anthony Fyles
Keyword(s):  
Gynecological Malignancies

Successful Control of Massive Vaginal Bleeding with Resuscitative Endovascular Balloon Occlusion of the Aorta and Pelvic Packing

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Emre Özlüer ◽  
Çagaç Yetis ◽  
Evrim Sayin ◽  
Mücahit Avcil
Keyword(s):  
Vaginal Bleeding ◽  
Balloon Occlusion ◽  
Emergency Physicians ◽  
Pelvic Packing ◽  
Gynecological Malignancies ◽  
Life Threatening ◽  
Successful Control ◽  
Endovascular Balloon Occlusion

Gynecological malignancies may present as life-threatening vaginal bleeding. Pelvic packing and Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) may be useful along with conventional vaginal packing when in terms of control of the hemorrhage. Emergency physicians should be able to perform these interventions promptly in order to save their patients from exsanguination.

Portal imaging based definition of the planning target volume during pelvic irradiation for gynecological malignancies

1999 ◽  
Vol 45 (1) ◽  
pp. 227-232 ◽  
Author(s):  
Ulrike Mock ◽  
Karin Dieckmann ◽  
Uwe Wolff ◽  
Thomas-Hendrik Knocke ◽  
Richard Pötter
Keyword(s):  
Planning Target Volume ◽  
Target Volume ◽  
Pelvic Irradiation ◽  
Portal Imaging ◽  
Gynecological Malignancies ◽  
Definition Of

scholarly journals Small Non-Coding-RNA in Gynecological Malignancies

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1085
Author(s):  
Shailendra Kumar Dhar Dwivedi ◽  
Geeta Rao ◽  
Anindya Dey ◽  
Priyabrata Mukherjee ◽  
Jonathan D. Wren ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Noncoding Rna ◽  
Molecular Mechanisms ◽  
P Element ◽  
Gynecologic Malignancies ◽  
Diagnosis And Prognosis ◽  
Gynecological Malignancies ◽  
Non Coding Rna ◽  
Therapeutic Research ◽  
Regulatory Functions

Gynecologic malignancies, which include cancers of the cervix, ovary, uterus, vulva, vagina, and fallopian tube, are among the leading causes of female mortality worldwide, with the most prevalent being endometrial, ovarian, and cervical cancer. Gynecologic malignancies are complex, heterogeneous diseases, and despite extensive research efforts, the molecular mechanisms underlying their development and pathology remain largely unclear. Currently, mechanistic and therapeutic research in cancer is largely focused on protein targets that are encoded by about 1% of the human genome. Our current understanding of 99% of the genome, which includes noncoding RNA, is limited. The discovery of tens of thousands of noncoding RNAs (ncRNAs), possessing either structural or regulatory functions, has fundamentally altered our understanding of genetics, physiology, pathophysiology, and disease treatment as they relate to gynecologic malignancies. In recent years, it has become clear that ncRNAs are relatively stable, and can serve as biomarkers for cancer diagnosis and prognosis, as well as guide therapy choices. Here we discuss the role of small non-coding RNAs, i.e., microRNAs (miRs), P-Element induced wimpy testis interacting (PIWI) RNAs (piRNAs), and tRNA-derived small RNAs in gynecological malignancies, specifically focusing on ovarian, endometrial, and cervical cancer.

PO-1127: Acute and late toxicity report of postoperative IG-IMRT for gynecological malignancies

2020 ◽  
Vol 152 ◽  
pp. S595
Author(s):  
M. La Vecchia ◽  
F. Cuccia ◽  
G. Ferrera ◽  
G. Mortellaro ◽  
D. Cespuglio ◽  
...  
Keyword(s):  
Late Toxicity ◽  
Gynecological Malignancies

Myometrial Responses to Beta-Adrenoceptor Antagonists in Gynecological Malignancies

2021 ◽  
pp. 1-8
Author(s):  
Beata Modzelewska ◽  
Marcin Jóźwik ◽  
Tomasz Kleszczewski ◽  
Stanisław Sulkowski ◽  
Maciej Jóźwik
Keyword(s):  
Ovarian Cancer ◽  
Cervical Cancer ◽  
Reference Group ◽  
Ex Vivo ◽  
Contractile Activity ◽  
Organ Bath ◽  
Human Uterus ◽  
Uterine Contractility ◽  
Beta Adrenoceptor ◽  
Gynecological Malignancies

Objective: The aim of the study was to determine the influence of beta-adrenoceptor (ADRB) antagonists on contractile activity of the nonpregnant human uterus in patients affected by gynecological malignancies. Design: This was a controlled and prospective ex vivo study. Setting: The work was conducted as a collaboration between 4 academic departments. Materials and Methods: Myometrial specimens were obtained from women undergoing hysterectomy for benign gynecological disorders (reference group; N = 15), and ovarian (N = 15), endometrial (N = 15), synchronous ovarian-endometrial (N = 3), and cervical cancer (N = 10). Contractions of myometrial strips in an organ bath before and after applications of ADRB antagonists (propranolol, bupranolol, SR 59230A, and butoxamine) were studied under isometric conditions. Results: Propranolol and bupranolol attenuated contractions in the endometrial and cervical cancer groups similar to that in the reference group (all p < 0.05), whereas opposite effects were observed in the ovarian and synchronous ovarian-endometrial cancer groups. SR 59230A and butoxamine significantly increased contractions in the ovarian cancer group (both p < 0.001). Limitations: These results require now to be placed into a firm clinical context. Conclusions: Our study indicates that ovarian cancer considerably alters contractile activity of the nonpregnant human uterus in response to ADRB antagonists. This suggests a pathogenetic role of beta-adrenergic pathways in this malignancy. Furthermore, propranolol and bupranolol substantially influence spontaneous uterine contractility.

EP-1148 PELVIC INSUFFICIENCY FRACTURES AFTER PELVIC IRRADIATION FOR GYNECOLOGICAL MALIGNANCIES

2012 ◽  
Vol 103 ◽  
pp. S443
Author(s):  
M. Abdulrehman ◽  
F. Santos ◽  
T. Cunha ◽  
M. Roldão
Keyword(s):  
Insufficiency Fractures ◽  
Pelvic Irradiation ◽  
Gynecological Malignancies

Inflammation: its role and interplay in the development of cancer, with special focus on gynecological malignancies

2008 ◽  
Vol 18 (4) ◽  
pp. 591-599 ◽  
Author(s):  
B. GOSWAMI ◽  
M. RAJAPPA ◽  
M. SHARMA ◽  
A. SHARMA
Keyword(s):  
Special Focus ◽  
Gynecological Malignancies

scholarly journals Prophylactic vesical instillations with 0.2% chondroitin sulfate may reduce symptoms of acute radiation cystitis in patients undergoing radiotherapy for gynecological malignancies

2011 ◽  
Vol 22 (6) ◽  
pp. 725-730 ◽  
Author(s):  
Menke H. Hazewinkel ◽  
Lukas J. A. Stalpers ◽  
Marcel G. Dijkgraaf ◽  
Jan-Paul W. R. Roovers
Keyword(s):  
Chondroitin Sulfate ◽  
Acute Radiation ◽  
Radiation Cystitis ◽  
Gynecological Malignancies
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