Cleavage Factor I (CF I)/Cleavage Factor II (CF II)

Keyword(s):  
Factor I ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tomoo Fujii ◽  
Manako Hanya ◽  
Kenta Murotani ◽  
Hiroyuki Kamei

Abstract Background Stigma associated with mental disorders is rooted among many pharmacists, and represents a major barrier to patient support in community-based psychiatry. We developed an assessment scale that is specifically designed to assess the level of stigma that pharmacists may have toward schizophrenia, and then examined the effects of reducing stigma with an educational program that focuses on communication with patients diagnosed with schizophrenia (PDS) using the newly developed Stigma Scale towards Schizophrenia for Community Pharmacists (SSCP). Methods SSCP was developed by exploratory factor analysis with promax rotation based on responses from 822 randomly selected community pharmacists. Furthermore, a randomized controlled trial was conducted for 115 community pharmacists to clarify the effects of reducing the stigma of schizophrenia using an educational program for them with a focus on communication with PDS. Participants were individually allocated to two groups: educational lecture group (56; only attending a lecture on schizophrenia) or contact-based intervention group (59; communicating with PDS and attending the lecture). The stigma assessment using SSCP was conducted immediately before and after the educational intervention. Results A total of 4 factors and 27 items were extracted from the exploratory factor analysis to comprise the SSCP. Cronbach’s α of SSCP, social distance at professional pharmacy service (factor I), attitudes towards PDS (factor II), self-disclosure (factor III), and social distance in personal (factor IV) were 0.89, 0.88, 0.76, 0.62, and 0.62, respectively. Educational program-related changes of the median (interquartile range) total SSCP score from baseline were − 9.0 (− 16.0 – − 5.0) in the contact-based intervention group and − 3.0 (− 7.0–1.0) in the educational lecture group, reflecting a significant reduction of stigma levels in the contact-based intervention group. On examining the SSCP subscales, scores for factor I and factor II significantly improved. The educational program was more effective for pharmacists aged 20–39 years or with negligible experience of communicating with PDS at work and/or in private life. Conclusions SSCP and the educational program for community pharmacists that focuses on communication with PDS were useful for assessing and reducing, respectively, the stigma attached by these pharmacists to schizophrenia. Trial registration UMIN Clinical Trials Registry (UMIN000043189, registered on January 30, 2021), Retrospectively registered.


1975 ◽  
Vol 18 (2) ◽  
pp. 229-241 ◽  
Author(s):  
Dorothy M. Aram ◽  
James E. Nation

Tests to measure comprehension, formulation, and repetition of certain phonologic, syntactic, and semantic aspects of language were administered to 47 children who had developmental language disorders. A factor analysis of the resultant scores indicated that three factors were present in the data. These factors are presented as six patterns of language performance, one for high loadings on the factor and one for low loadings. The six patterns are (1) repetition strength (Factor I, high); (2) nonspecific formulation-repetition deficit (Factor I, low); (3) generalized low performance (Factor II, high); (4) phonologic comprehension-formulation-repetition deficit (Factor II, low); (5) comprehension deficit (Factor III, high); and (6) formulation-repetition deficit (Factor III, low). Possible relations among these patterns and nonlinguistic measures (sex, race, age, nonverbal intelligence, socioeconomic status, and status of the peripheral speech mechanism) were investigated. Two of the patterns of language performance were found to be related significantly to age. On Factor II, the younger children tended to get high loadings (generalized low performance) while the older children tended to get low loadings (phonologic comprehension-formulation-repetition deficit).


2019 ◽  
Vol 1 (2) ◽  
pp. 113-122
Author(s):  
Heru Kurniawan ◽  
Asmah Indrawati ◽  
Gusmeizal Gusmeizal

Okra plant is becoming to be one of favortite vegetable in Indonesia since then the deman of this plant is growing very rapidly. The aim of this research is to Utilize Palm Oil Liquid Organic Fertilizer and M-Bio Biofertilizer Against Growth and Production in Okra Plants (Abelmoschusesculentus  L.  Moench).  This  study  used  a  Randomized  Block  Design (RBD) with 2 replications. Factorial consisting of II treatment factors, Factor I treatment given P0: Without Liquid Palm Oil Organic Fertilizer, P1: Provision of PKS liquid fertilizer and Factor II, treatment of giving M-Bio. Parameters observed in this study were  vegetative dan generative. The results showed that the treatment of oil palm liquid organic fertilizer had no significant effect on vegetative and generative observed parameters. The treatment of M-Bio biofertilizer significantly affected the vegetative and generative observation parameters where the best dose was treatment  6%. The treatment of the combination of liquid organic fertilizer from palm oil waste and M-Bio biological fertilizer has no significant effect on all parameters of vegetative and generative observations.


2004 ◽  
Vol 2 (3) ◽  
pp. 243-253 ◽  
Author(s):  
CHERYL L. NEKOLAICHUK ◽  
EDUARDO BRUERA

Objective:The purpose of this study was to gather validity evidence for an innovative experience of hope scale, theHope Differential-Short (HDS), and evaluate its clinical utility for assessing hope in advanced cancer patients.Methods:A consecutive sampling approach was used to recruit 96 patients from an inpatient tertiary palliative care unit and three hospice settings. Each participant completed an in-person survey interview, consisting of the following measures: HDS (nine items), Herth Hope Index (HHI), hope visual analog scale (Hope-VAS) and Edmonton Symptom Assessment System (ESAS).Results:Using factor analytic procedures, a two-factor structure for the HDS was identified, consisting ofauthentic spirit(Factor I) andcomfort(Factor II). The HDS factors had good overall internal consistency (α = 0.83), with Factor I (α = 0.83) being higher than Factor II (α = 0.69). The two factors positively correlated with the HHI, Hope-VAS, and one of the ESAS visual analog scales, well-being (range: 0.38 to 0.64) and negatively correlated with depression and anxiety, as measured by the ESAS (range: −0.25 to −0.42).Significance of results:This is the first validation study of the HDS in advanced cancer patients. Its promising psychometric properties and brief patient-oriented nature provide a solid initial foundation for its future use as a clinical assessment measure in oncology and palliative care. Additional studies are warranted to gather further validity evidence for the HDS before its routine use in clinical practice.


2017 ◽  
Vol 63 (No. 5) ◽  
pp. 231-235 ◽  
Author(s):  
Gugała Marek ◽  
Zarzecka Krystyna ◽  
Sikorska Anna ◽  
Kapela Krzysztof ◽  
Niewęgłowski Marek ◽  
...  

The objective of the study was to determine the effect of the soil conditioner UG<sub>max</sub> application on phenol and glycoalkaloid content in the tubers of two table potato cultivars. The following factors were examined: factor I − cultivars: Satina and Tajfun; factor II − five application methods of the soil conditioner UG<sub>max</sub>: (1) control − no UG<sub>max</sub> application; (2) 1.0 L/ha UG<sub>max</sub> before planting; (3) 0.5 L/ha UG<sub>max</sub> before planting + 0.25 L/ha at potato height of 10–15 cm + 0.25 L/ha in flower bud phase; (4) 1.0 L/ha UG<sub>max</sub> before planting + 0.50 L/ha at potato height of 10–15 cm + in 0.50 L/ha in flower bud phase; (5) UG<sub>max</sub> applied after emergence when plants were 10–15 cm high at the rate of 0.5 L/ha, and at the stage of flower buds at the rate of 0.5 L/ha. The highest concentration of phenols and glycoalkaloids was recorded in plots where UG<sub>max</sub> was applied prior to potato planting at the rate of 1.0 L/ha, when plants were 10–15 cm high at the rate of 0.5 L/ha and at the stage of flower buds at the rate of 0.5 L/ha.


1980 ◽  
Vol 45 (3) ◽  
pp. 415-422 ◽  
Author(s):  
Jeffrey L. Danhauer ◽  
Gordon W. Blood ◽  
Ingrid M. Blood ◽  
Nancy Gomez

This study determined whether professional and lay observers had similar impressions of preschoolers wearing hearing aids and if the size of the aid affected ratings. Stimuli consisted of three photographic slides of nine normally-hearing and speaking male preschoolers wearing (1) a body-type hearing aid, (2) a post-auricular type aid, and (3) no aid. Slides were accompanied by taped speech samples. Stimuli were presented to 75 professional and 75 lay observers who rated the children on a semantic differential scale containing 15 adjectives. Ratings were submitted to a factor analysis revealing Factor I as achievement and Factor II as appearance. Results of MANOVAs revealed that neither professional nor lay observers discriminated against the children on appearance regardless of the presence of a hearing aid, but that both groups rated them significantly poorer on achievement when an aid was present. Lay observers' ratings showed a bias against the size of the aid, while professionals exhibited negative impressions whenever an aid was present, regardless of its size. These findings indicate that the "hearing aid effect" was present on variables of achievement even for normal-hearing preschoolers.


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