A Coupled FE Analysis of the Intervertebral Disc Based on a Multiphasic TPM Formulation

ABSTRACTDisc rheological parameters regulate the mechanical and biological function of intervertebral disc. The knowledge of effects of degeneration on disc rheology can be beneficial for the design of new disc implants or therapy. We developed two material property identification protocols, i.e., inverse poroelas-tic finite element analysis, and biphasic closed form solution. These protocols were used to find the material properties of intact, moderate and severe degenerated porcine discs. Comparing these two computational protocols for intact and artificial degenerated discs showed they are valid in defining bi-phasic/poroelastic properties. We found that enzymatic agent disrupts the functional interactions of proteoglycans which decreased hydraulic permeability and aggregate modulus but increased the Poisson's ratio. The fatigue loading, which damages disc structure, and squeezes and occludes the matrix pores, further decreased the hydraulic permeability and the Poisson's ratio but increased the elastic modulus. The FE simulations showed the stress experienced during the creep test increases with severe degeneration but steady-state fluid loss decreases for the both moderate and severe degenerated discs. Discriminant analysis declared that the probability of correct classification using the FE analysis is higher than the results of the closed form solution. The specimen-specific models extracted from FE analysis can be additionally used for complimentary investigations on disc biomechanics.

Download Full-text

A multiphasic FE analysis of an L4-L5 motion segment with focus on the inhomogeneous intervertebral disc

Journal of Biomechanics ◽

10.1016/s0021-9290(06)84701-9 ◽

2006 ◽

Vol 39 ◽

pp. S418-S419

Author(s):

W. Ehlers ◽

B. Markert ◽

N. Karajan

Keyword(s):

Intervertebral Disc ◽

Fe Analysis ◽

Motion Segment

Download Full-text

CCN2 Functions as Anti-Inflammatory Molecule in the Intervertebral Disc

Global Spine Journal ◽

10.1055/s-0034-1376756 ◽

2014 ◽

Vol 4 (1_suppl) ◽

pp. s-0034-1376756-s-0034-1376756

Author(s):

Makarand V. Risbud

Keyword(s):

Intervertebral Disc ◽

Inflammatory Molecule ◽

Anti Inflammatory

Download Full-text

Loading-Induced Stress Response in the Intervertebral Disc

Global Spine Journal ◽

10.1055/s-0034-1376604 ◽

2014 ◽

Vol 4 (1_suppl) ◽

pp. s-0034-1376604-s-0034-1376604

Author(s):

W. H. Chooi ◽

S. C. Chan ◽

B. Gantenbein-Ritter ◽

B. P. Chan

Keyword(s):

Stress Response ◽

Intervertebral Disc ◽

Induced Stress

Download Full-text

Immortalization of Human Cartilage Endplate Stem Cell from Degenerated Human Intervertebral Disc

Global Spine Journal ◽

10.1055/s-0034-1376589 ◽

2014 ◽

Vol 4 (1_suppl) ◽

pp. s-0034-1376589-s-0034-1376589

Author(s):

M. Liu ◽

B. Huang ◽

Y. Zhou

Keyword(s):

Stem Cell ◽

Intervertebral Disc ◽

Human Cartilage ◽

Cartilage Endplate

Download Full-text

DNA Demethylation Regulates Anabolic and Catabolic Gene Expression in Intervertebral Disc Cells

Global Spine Journal ◽

10.1055/s-0034-1376587 ◽

2014 ◽

Vol 4 (1_suppl) ◽

pp. s-0034-1376587-s-0034-1376587

Author(s):

N. Chutkan ◽

R. Sangani ◽

H. Zhou ◽

S. Fulzele

Keyword(s):

Gene Expression ◽

Intervertebral Disc ◽

Dna Demethylation ◽

Catabolic Gene ◽

Disc Cells

Download Full-text

Melatonin: Protection of the Intervertebral Disc

Melatonin Research ◽

10.32794/mr11250028 ◽

2019 ◽

Vol 2 (3) ◽

pp. 1-9

Author(s):

Russel J Reiter ◽

Sergio Rosales-Corral ◽

Ramaswamy Sharma

Keyword(s):

Intervertebral Disc ◽

Molecular Mechanisms ◽

Intervertebral Discs ◽

Lumbar Pain ◽

Low Back ◽

Work Time ◽

Protective Actions ◽

Aging Populations ◽

Definition Of ◽

Endogenous Melatonin

Low back pain (lumbar pain) due to injury of or damage to intervertebral discs is common in all societies. The loss of work time as a result of this problem is massive. Recent research suggests that melatonin may prevent or counteract intervertebral disc damage. This may be especially relevant in aging populations given that endogenous melatonin, in most individuals, dwindles with increasing age. The publications related to melatonin and its protection of the intervertebral disc are reviewed herein, including definition of some molecular mechanisms that account for melatonin’s protective actions.

Download Full-text