Melatonin: Protection of the Intervertebral Disc

2019 ◽  
Vol 2 (3) ◽  
pp. 1-9
Author(s):  
Russel J Reiter ◽  
Sergio Rosales-Corral ◽  
Ramaswamy Sharma
Keyword(s):  
Intervertebral Disc ◽  
Molecular Mechanisms ◽  
Intervertebral Discs ◽  
Lumbar Pain ◽  
Low Back ◽  
Work Time ◽  
Protective Actions ◽  
Aging Populations ◽  
Definition Of ◽  
Endogenous Melatonin

     Low back pain (lumbar pain) due to injury of or damage to intervertebral discs is common in all societies.  The loss of work time as a result of this problem is massive.  Recent research suggests that melatonin may prevent or counteract intervertebral disc damage. This may be especially relevant in aging populations given that endogenous melatonin, in most individuals, dwindles with increasing age. The publications related to melatonin and its protection of the intervertebral disc are reviewed herein, including definition of some molecular mechanisms that account for melatonin’s protective actions. 

scholarly journals Mitochondrial quality control in intervertebral disc degeneration

2021 ◽  
Author(s):  
Yu Song ◽  
Saideng Lu ◽  
Wen Geng ◽  
Xiaobo Feng ◽  
Rongjin Luo ◽  
...  
Keyword(s):  
Quality Control ◽  
Intervertebral Disc ◽  
Disc Degeneration ◽  
Intervertebral Disc Degeneration ◽  
Molecular Mechanisms ◽  
Cell Function ◽  
Current Knowledge ◽  
Mitochondrial Dynamics ◽  
Intervertebral Discs ◽  
Mitochondrial Quality Control

AbstractIntervertebral disc degeneration (IDD) is a common and early-onset pathogenesis in the human lifespan that can increase the risk of low back pain. More clarification of the molecular mechanisms associated with the onset and progression of IDD is likely to help establish novel preventive and therapeutic strategies. Recently, mitochondria have been increasingly recognized as participants in regulating glycolytic metabolism, which has historically been regarded as the main metabolic pathway in intervertebral discs due to their avascular properties. Indeed, mitochondrial structural and functional disruption has been observed in degenerated nucleus pulposus (NP) cells and intervertebral discs. Multilevel and well-orchestrated strategies, namely, mitochondrial quality control (MQC), are involved in the maintenance of mitochondrial integrity, mitochondrial proteostasis, the mitochondrial antioxidant system, mitochondrial dynamics, mitophagy, and mitochondrial biogenesis. Here, we address the key evidence and current knowledge of the role of mitochondrial function in the IDD process and consider how MQC strategies contribute to the protective and detrimental properties of mitochondria in NP cell function. The relevant potential therapeutic treatments targeting MQC for IDD intervention are also summarized. Further clarification of the functional and synergistic mechanisms among MQC mechanisms may provide useful clues for use in developing novel IDD treatments.

scholarly journals Aging and degeneration of the intervertebral disc: review of basic science

2015 ◽  
Vol 14 (2) ◽  
pp. 144-148 ◽  
Author(s):  
Josemberg da Silva Baptista ◽  
Ricardo Bragança de Vasconcellos Fontes ◽  
Edson Aparecido Liberti
Keyword(s):  
Extracellular Matrix ◽  
Intervertebral Disc ◽  
Basic Science ◽  
Intervertebral Discs ◽  
Research Field ◽  
Future Research ◽  
Low Back ◽  
Lumbar Intervertebral Disc ◽  
Soluble Cell ◽  
The Difference

<p>Currently there is a growing interest in the study of intervertebral discs due to loss of manpower brought to society by low back and neck pains. These papers seek to delineate the difference between normal aging and disc degeneration, trying to understand what factor would be determining for the second condition. Thus, the morphology field was expanded and knowledge on the structure of intervertebral discs currently uses the research field of cell and molecular biology, and genetics. The results indicate that regardless of age or condition, the intervertebral disc undergoes long and extensive remodeling of its constituents, which are influenced by several factors: environmental, soluble, cell growth and extracellular matrix. In this literature review we describe the biological characteristics of the cervical and lumbar intervertebral disc with a focus on basic science of aging and degeneration, selecting the latest findings and discussions of the area, which influence future research and clinical thoughts.</p>

scholarly journals Applications of Functionalized Hydrogels in the Regeneration of the Intervertebral Disc

2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Caiping Yan ◽  
Xingkuan Wang ◽  
Chao Xiang ◽  
Yong Wang ◽  
Chaoyu Pu ◽  
...  
Keyword(s):  
Intervertebral Disc ◽  
Intervertebral Disc Degeneration ◽  
Intervertebral Discs ◽  
Low Back ◽  
Hydrogel Scaffolds ◽  
Disc Regeneration ◽  
Future Developments ◽  
Intervertebral Disc Regeneration ◽  
Responsive Hydrogels

Intervertebral disc degeneration (IDD) is caused by genetics, aging, and environmental factors and is one of the leading causes of low back pain. The treatment of IDD presents many challenges. Hydrogels are biomaterials that possess properties similar to those of the natural extracellular matrix and have significant potential in the field of regenerative medicine. Hydrogels with various functional qualities have recently been used to repair and regenerate diseased intervertebral discs. Here, we review the mechanisms of intervertebral disc homeostasis and degeneration and then discuss the applications of hydrogel-mediated repair and intervertebral disc regeneration. The classification of artificial hydrogels and natural hydrogels is then briefly introduced, followed by an update on the development of functional hydrogels, which include noncellular therapeutic hydrogels, cellular therapeutic hydrogel scaffolds, responsive hydrogels, and multifunctional hydrogels. The challenges faced and future developments of the hydrogels used in IDD are discussed as they further promote their clinical translation.

Quantification of In Vivo Deformation of Healthy Lumbar Intervertebral Discs in Flexion

2012 ◽  
Author(s):  
Tina M. Nagel ◽  
Victor H. Barocas ◽  
David J. Nuckley
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Intervertebral Disc ◽  
Annulus Fibrosus ◽  
Intervertebral Discs ◽  
Low Back ◽  
Ivd Degeneration ◽  
Level 2 ◽  
Walled Cylinder

Intervertebral disc (IVD) degeneration is hypothesized to be the precursor to non-specific low back pain, which is a widespread problem [1]. However, before disc degeneration can be understood, a better understanding of healthy discs must be gained. The disc is a short thick-walled cylinder with a gelatinous center, the nucleus pulposus, and a largely concentric, layered collagenous ring, the annulus fibrosus, Figure 1. The layers are referred to as lamella. The IVD is integral to the strength and flexibility of the spine. Whole disc mechanics have been widely studied, but degeneration occurs at the fiber level [2]. To understand the mechanics of degeneration, testing needs to be performed at a finer level where degenerative / injury effects occur. These effects such as tears occur in the annular lamella.

EXPERIENCE OF CONSERVATIVE TREATMENT OF INTERVERTEBRAL DISC HERNIAS WITH CARIFLEX GEL AND CREAM IN AMBULATORY CONDITIONS

2020 ◽  
Vol 3 (1) ◽  
pp. 6-8
Author(s):  
Zufar ADAMBAEV ◽  
◽  
Ibodulla KILICHEV ◽  
Tuygunoy XODJANOVA
Keyword(s):  
Comparative Analysis ◽  
Conservative Treatment ◽  
Intervertebral Disc ◽  
Range Of Motion ◽  
Comparative Evaluation ◽  
Intervertebral Discs ◽  
Neurological Manifestations ◽  
Complex Therapy

A complex therapy of patients with degenerative-dystrophic diseases of the spine with herniated intervertebral discs with neurological manifestations was carried out with the addition of phonophoresis Kariflex gel followed by segmental massage with Kariflex cream. The comparative evaluation of the method was carried out in 89 patients. Comparative analysis revealed the reliable efficiency of the method used. Against the background of the proposed therapy, there was a significant decrease in pain and muscle-tonic syndromes, an increase in the range of motion in the spine

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