CCN2 Functions as Anti-Inflammatory Molecule in the Intervertebral Disc

2014 ◽  
Vol 4 (1_suppl) ◽  
pp. s-0034-1376756-s-0034-1376756
Author(s):  
Makarand V. Risbud
Keyword(s):  
Intervertebral Disc ◽  
Inflammatory Molecule ◽  
Anti Inflammatory

Comparative analysis of neurological recovery and adverse effects in chondrodystrophic dogs with thoracolumbar intervertebral disc herniation treated with methylprednisolone versus non-steroidal anti-inflammatory drugs

2021 ◽  
Author(s):  
William McCartney ◽  
Ciprian Andrei Ober ◽  
Maria Benito
Keyword(s):  
Treatment Group ◽  
Side Effects ◽  
Intervertebral Disc ◽  
Disc Herniation ◽  
Sodium Succinate ◽  
Neurological Recovery ◽  
Intervertebral Disc Herniation ◽  
Cord Injury ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Thoracolumbar intervertebral disc herniation is a common neurologic disease presented to the small-animal practitioner. The use of methylprednisolone sodium succinate (MPSS) as an adjunct to surgical decompression in cases of acute spinal cord injury following intervertebral disc extrusion is controversial. A prospective study was undertaken to compare the preoperative use of MPSS and non-steroidal anti-inflammatory drugs (NSAIDs) in 40 chondrodystrophic dogs presenting with similar signs and undergoing spinal decompressive surgery. Twenty dogs received MPSS and 20 had NSAIDs administered preoperatively. Dogs were administered with either MPSS intravenously 20 minutes before surgery (30 mg/kg) or NSAID (meloxicam 0.2mg/kg or carprofen 4 mg/kg) subcutaneously 20 minutes before surgery. Dogs were evaluated by neurologic examination of gait 24 hours postoperatively, at time of discharge and then at 8 weeks. The neurological recovery were similar in both groups, but the frequency of side effects such as vomiting (MPSS group: 90% versus NSAIDs group: 55%), and anorexia within the first three days (present in all 20 dogs pretreated with MPSS) was significantly different, with complications being more prevalent in the MPSS group. Side effects were significantly more evident with MPSS treatment group –including vomiting and anorexia during the first 3 days after surgery– than with NSAID treatment group, with a neurological recovery similar in both groups.

Inhibition of secretory phospholipase A2 enzyme by bilirubin: A new role as endogenous anti-inflammatory molecule

2005 ◽  
Vol 276 (1-2) ◽  
pp. 219-225 ◽  
Author(s):  
Noor Mohamed Jameel ◽  
Brigitte M. Frey ◽  
Felix J. Frey ◽  
T. Veerabasappa Gowda ◽  
Bannikuppe S. Vishwanath
Keyword(s):  
Phospholipase A2 ◽  
Secretory Phospholipase A2 ◽  
Secretory Phospholipase ◽  
Inflammatory Molecule ◽  
Anti Inflammatory

Group IIA Secretory PLA2 Inhibition by Ursolic Acid: A Potent Anti-Inflammatory Molecule

2007 ◽  
Vol 7 (8) ◽  
pp. 801-809 ◽  
Author(s):  
A. Nataraj ◽  
C. Raghavendra Gowda ◽  
R. Rajesh ◽  
B. Vishwanath
Keyword(s):  
Ursolic Acid ◽  
Inflammatory Molecule ◽  
Anti Inflammatory

The intestinal microbial metabolite desaminotyrosine is an anti‐inflammatory molecule that modulates local and systemic immune homeostasis

2020 ◽  
Vol 34 (12) ◽  
pp. 16117-16128
Author(s):  
Yanxia Wei ◽  
Jing Gao ◽  
Yanbo Kou ◽  
Mengnan Liu ◽  
Liyuan Meng ◽  
...  
Keyword(s):  
Immune Homeostasis ◽  
Microbial Metabolite ◽  
Inflammatory Molecule ◽  
Anti Inflammatory

scholarly journals Endothelium-Derived 5-Methoxytryptophan Is a Circulating Anti-Inflammatory Molecule That Blocks Systemic Inflammation

2016 ◽  
Vol 119 (2) ◽  
pp. 222-236 ◽  
Author(s):  
Yi-Fu Wang ◽  
Yu-Juei Hsu ◽  
Hsu-Feng Wu ◽  
Guan-Lin Lee ◽  
Ya-Sung Yang ◽  
...  
Keyword(s):  
Systemic Inflammation ◽  
Inflammatory Molecule ◽  
Anti Inflammatory

Roles for glycosylation in the anti-inflammatory molecule CD59

1997 ◽  
Vol 25 (4) ◽  
pp. 1177-1184 ◽  
Author(s):  
P. M. Rudd ◽  
B. P. Morgan ◽  
M. R. Wormald ◽  
D. J. Harvey ◽  
C. W. van den Berg ◽  
...  
Keyword(s):  
Inflammatory Molecule ◽  
Anti Inflammatory

scholarly journals Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment

Molecules ◽  
2011 ◽  
Vol 16 (6) ◽  
pp. 4567-4598 ◽  
Author(s):  
Purusotam Basnet ◽  
Natasa Skalko-Basnet
Keyword(s):  
Cancer Treatment ◽  
Inflammatory Molecule ◽  
Anti Inflammatory
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