Very High Frequency Oscillations of Heart Rate Variability in Healthy Humans and in Patients with Cardiovascular Autonomic Neuropathy

2018 ◽  
pp. 49-70 ◽  
Author(s):  
Mario Estévez-Báez ◽  
Calixto Machado ◽  
Julio Montes-Brown ◽  
Javier Jas-García ◽  
Gerry Leisman ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Autonomic Neuropathy ◽  
High Frequency ◽  
Cardiovascular Autonomic Neuropathy ◽  
Very High Frequency ◽  
Healthy Humans ◽  
High Frequency Oscillations ◽  
Very High

11. Very high frequency oscillations in medial temporal structures

2011 ◽  
Vol 122 (8) ◽  
pp. e11
Author(s):  
Miyako Yamaguchi ◽  
Kiyohito Terada ◽  
Koichi Baba ◽  
Fumihiro Nakamura ◽  
Kazumi Matsuda ◽  
...  
Keyword(s):  
High Frequency ◽  
Very High Frequency ◽  
High Frequency Oscillations ◽  
Temporal Structures ◽  
Very High

scholarly journals Circulating Inflammatory Markers Are Inversely Associated with Heart Rate Variability Measures in Type 1 Diabetes

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Anne-Marie L. Wegeberg ◽  
Tina Okdahl ◽  
Tina Fløyel ◽  
Christina Brock ◽  
Niels Ejskjaer ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 1 Diabetes ◽  
Adhesion Molecules ◽  
Autonomic Neuropathy ◽  
Vagal Tone ◽  
Cardiovascular Autonomic Neuropathy ◽  
Intercellular Adhesion Molecule ◽  
Cardiac Vagal Tone

Introduction. A neuroimmune communication exists, and compelling evidence suggests that diabetic neuropathy and systemic inflammation are linked. Our aims were (1) to investigate biomarkers of the ongoing inflammation processes including cytokines, adhesion molecules, and chemokines and (2) to associate the findings with cardiovascular autonomic neuropathy in type 1 diabetes by measuring heart rate variability and cardiac vagal tone. Materials and Methods. We included 104 adults with type 1 diabetes. Heart rate variability, time domain, and frequency domains were calculated from a 24-hour Holter electrocardiogram, while cardiac vagal tone was determined from a 5-minute electrocardiogram. Cytokines (interleukin- (IL-) 1α, IL-4, IL-12p70, IL-13, IL-17, and tumor necrosis factor- (TNF-) α), adhesion molecules (E-selectin, P-selectin, and intercellular adhesion molecule- (ICAM-) 1), and chemokines (chemokine (C-C motif) ligand (CCL)2, CCL3, CCL4, and C-X-C motif chemokine (CXCL)10) were assessed using a Luminex multiplexing technology. Associations between concentrations of inflammatory biomarkers and continuous variables of heart rate variability and cardiac vagal tone were estimated using multivariable linear regression adjusting for age, sex, disease duration, and smoking. Results. Participants with the presence of cardiovascular autonomic neuropathy had higher systemic levels of IL-1α, IL-4, CCL2, and E-selectin than those without cardiovascular autonomic neuropathy. IL-1α, IL-4, IL-12, TNF-α, and E-selectin were inversely associated with both sympathetic and parasympathetic heart rate variability measures (p>0.01). Discussion. Our results show that several pro- and anti-inflammatory factors, believed to be involved in the progression of diabetic polyneuropathy, are associated with cardiovascular autonomic neuropathy, suggesting that these factors may also contribute to the pathogenesis of cardiovascular autonomic neuropathy. Our findings emphasize the importance of the neuroimmune regulatory system in the pathogenesis of neuropathy in type 1 diabetes.

Sign in / Sign up

Export Citation Format

Share Document