Organ dysfunction in circulatory shock — altered perfusion, metabolism or tight junctions? Do we need a shift of paradigm?

2007 ◽  
pp. 577-585
Author(s):  
J. J. Tenhunen
Keyword(s):  
Tight Junctions ◽  
Organ Dysfunction ◽  
Circulatory Shock

scholarly journals Recovery from profound acidosis (pH 6.685) in multi-organ dysfunction syndrome

2019 ◽  
pp. 175114371987010
Author(s):  
Eryl A Davies ◽  
Christopher Saleh ◽  
Jonathan Bannard-Smith
Keyword(s):  
Decision Making ◽  
Emergency Department ◽  
Cardiac Arrest ◽  
Critical Care ◽  
Organ Dysfunction ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Circulatory Shock ◽  
Arterial Ph ◽  
Multi Organ Dysfunction Syndrome

Acidosis is a common feature of patients referred to critical care from the emergency department. We present the case of a 49-year-old female with multi-organ dysfunction syndrome (MODS) and an arterial pH of 6.685 on arrival to the emergency department. This case is unique as the patient was in circulatory shock with MODS from rhabdomyolysis on arrival and had not suffered a cardiac arrest. We believe this to be the first reported case of full recovery from such an extreme metabolic disturbance in this context, and discuss the relevance of profound acidosis to early clinical decision-making.

Principles of care of critically ill patients

2018 ◽  
pp. 143-150
Author(s):  
Abdullah Jibawi ◽  
Mohamed Baguneid ◽  
Arnab Bhowmick
Keyword(s):  
High Risk ◽  
Brain Stem ◽  
Critically Ill ◽  
Organ Dysfunction ◽  
Critically Ill Patients ◽  
Blood Gases ◽  
Scoring Systems ◽  
Perioperative Period ◽  
Circulatory Shock ◽  
Risk Patients

Surgeons should be competent in identifying and treating high-risk patients in the perioperative period, including ability to identify, assess, and initiate treatment for organ dysfunction and circulatory shock, obtain and interpret blood gases, use blood products and fluid composites, support nutrition, treat sepsis, and identify and diagnose brain stem death. The chapter tackles main issues in the diagnosis and treatment of such patients, defines criteria and scoring systems in use for critically ill patients, and summarize treatment principles and approaches recommendations.

scholarly journals Acute Generalized Exanthematous Pustulosis with Multiple Organ Failure

2021 ◽  
pp. 47-53
Author(s):  
Tausif Syed ◽  
Abdullah Sayied Abdullah ◽  
Mahmood Mubasher ◽  
Zohaib Yousaf ◽  
Mouhand F.H. Mohamed ◽  
...  
Keyword(s):  
Multiple Organ Failure ◽  
Organ Failure ◽  
Organ Dysfunction ◽  
Multiple Organ ◽  
Circulatory Shock ◽  
Multiple Organ Dysfunction ◽  
Middle Aged ◽  
Acute Generalized Exanthematous Pustulosis ◽  
Limiting Condition ◽  
Exanthematous Pustulosis

Acute generalized exanthematous pustulosis (AGEP) is a rare, self-limiting condition. It presents with sterile skin pustules. We present a middle-aged lady with fluid nonresponsive circulatory shock and multiple organ dysfunction secondary to AGEP.

Freeze-etch observations on the tight junctions of sertoli cells grown in organ culture with FSH

1978 ◽  
Vol 36 (2) ◽  
pp. 340-341
Author(s):  
Rita Meyer ◽  
Zoltan Posalaky ◽  
Dennis Mcginley
Keyword(s):  
Organ Culture ◽  
Tight Junctions ◽  
Sertoli Cell ◽  
Germ Cells ◽  
Sertoli Cells ◽  
Barrier Function ◽  
Cell Junction ◽  
Intramembranous Particles ◽  
Junctional Complexes ◽  
Oriented Parallel

The Sertoli cell tight junctional complexes have been shown to be the most important structural counterpart of the physiological blood-testis barrier. In freeze etch replicas they consist of extensive rows of intramembranous particles which are not only oriented parallel to one another, but to the myoid layer as well. Thus the occluding complex has both an internal and an overall orientation. However, this overall orientation to the myoid layer does not seem to be necessary to its barrier function. The 20 day old rat has extensive parallel tight junctions which are not oriented with respect to the myoid layer, and yet they are inpenetrable by lanthanum. The mechanism(s) for the control of Sertoli cell junction development and orientation has not been established, although such factors as the presence or absence of germ cells, and/or hormones, especially FSH have been implicated.

Disseminated intravascular coagulation in meningococcal sepsis

2003 ◽  
Vol 23 (03) ◽  
pp. 125-130 ◽  
Author(s):  
S. Zeerleder ◽  
R. Zürcher Zenklusen ◽  
C. E. Hack ◽  
W. A. Wuillemin
Keyword(s):  
Organ Dysfunction ◽  
Disseminated Intravascular Coagulation ◽  
Skin Necrosis ◽  
Multiple Organ ◽  
Meningococcal Sepsis ◽  
Multiple Organ Dysfunction ◽  
Intravascular Coagulation ◽  
Therapeutic Concepts ◽  
New Therapeutic Concepts ◽  
Coagulation And Fibrinolysis

SummaryWe report on a man (age: 49 years), who died from severe meningococcal sepsis with disseminated intravascular coagulation (DIC), multiple organ dysfunction syndrome and extended skin necrosis. We discuss in detail the pathophysiology of the activation of coagulation and fibrinolysis during sepsis. The article discusses new therapeutic concepts in the treatment of disseminated intravascular coagulation in meningococcal sepsis, too.

Multiple Organ Dysfunction Syndrome of Alcoholic Origin in an 18-Year-Old Patient

2018 ◽  
Vol 2 (12) ◽  
Author(s):  
Francesco Gazia ◽  
Giacomo De Luca ◽  
Imbalzano Gabriele ◽  
Vincenzo Pellicanò
Keyword(s):  
Organ Dysfunction ◽  
Multiple Organ Dysfunction Syndrome ◽  
Multiple Organ ◽  
Multiple Organ Dysfunction
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