Molecularly Targeted Therapy for Osteosarcoma: Where Do We Go from Here?

2010 ◽  
pp. 459-498
Author(s):  
Rosanna Ricafort ◽  
Richard Gorlick
Keyword(s):  
Targeted Therapy ◽  
Molecularly Targeted Therapy

Mutually Synergistic Nanoparticles for Effective Thermo-Molecularly Targeted Therapy

2017 ◽  
Vol 27 (39) ◽  
pp. 1702834 ◽  
Author(s):  
Huanhuan Luo ◽  
Qiaoli Wang ◽  
Yibin Deng ◽  
Tao Yang ◽  
Hengte Ke ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Molecularly Targeted Therapy

scholarly journals BCR/ABL1-Like Acute Lymphoblastic Leukemia: From Diagnostic Approaches to Molecularly Targeted Therapy

2021 ◽  
pp. 1-9
Author(s):  
Anna Płotka ◽  
Krzysztof Lewandowski
Keyword(s):  
Flow Cytometry ◽  
Targeted Therapy ◽  
Acute Lymphoblastic Leukemia ◽  
High Risk ◽  
Lymphoblastic Leukemia ◽  
Genetic Alterations ◽  
Diagnostic Analysis ◽  
Cell Precursor ◽  
Molecularly Targeted Therapy ◽  
Diagnostic Approaches

<b><i>Background:</i></b> <i>BCR/ABL1</i>-like acute lymphoblastic leukemia is a newly recognized high-risk subtype of ALL, characterized by the presence of genetic alterations activating kinase and cytokine receptor signaling. This subtype is associated with inferior outcomes, compared to other B-cell precursor ALL. <b><i>Summary:</i></b> The recognition of <i>BCR/ABL1</i>-like ALL is challenging due to the complexity of underlying genetic alterations. Rearrangements of <i>CRLF2</i> are the most frequent alteration in <i>BCR/ABL1</i>-like ALL and can be identified by flow cytometry. The identification of <i>BCR/ABL1</i>-like ALL can be achieved with stepwise algorithms or broad-based testing. The main goal of the diagnostic analysis is to detect the underlying genetic alterations, which are critical for the diagnosis and targeted therapy. <b><i>Key Messages:</i></b> The aim of the manuscript is to review the available data on <i>BCR/ABL1</i>-like ALL characteristics, diagnostic algorithms, and novel, molecularly targeted therapeutic options.

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