Bimodal Liposomes and Paramagnetic QD-Micelles for Multimodality Molecular Imaging of Tumor Angiogenesis

2007 ◽  
pp. 487-512
Author(s):  
Willem J.M. Mulder ◽  
Gustav J. Strijkers ◽  
Rolf Koole ◽  
Celso De Mello Donega ◽  
Gert Storm ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Tumor Angiogenesis

scholarly journals Molecular imaging of tumor angiogenesis using αvβ3-integrin targeted multimodal quantum dots

Angiogenesis ◽  
2008 ◽  
Vol 12 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Willem J. M. Mulder ◽  
Karolien Castermans ◽  
Judy R. van Beijnum ◽  
Mirjam G. A. oude Egbrink ◽  
Patrick T. K. Chin ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Molecular Imaging ◽  
Tumor Angiogenesis ◽  
Αvβ3 Integrin

scholarly journals Improved Magnetic Resonance Molecular Imaging of Tumor Angiogenesis by Avidin-Induced Clearance of Nonbound Bimodal Liposomes

Neoplasia ◽  
2008 ◽  
Vol 10 (12) ◽  
pp. 1459-1469 ◽  
Author(s):  
Geralda A.F. van Tilborg ◽  
Willem J.M. Mulder ◽  
Daisy W.J. van der Schaft ◽  
Chris P.M. Reutelingsperger ◽  
Arjan W. Griffioen ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Magnetic Resonance ◽  
Tumor Angiogenesis

A Lipopeptide-Based αvβ3 Integrin-Targeted Ultrasound Contrast Agent for Molecular Imaging of Tumor Angiogenesis

2015 ◽  
Vol 41 (10) ◽  
pp. 2765-2773 ◽  
Author(s):  
Fei Yan ◽  
Xiuxia Xu ◽  
Yihan Chen ◽  
Zhiting Deng ◽  
Hongmei Liu ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Contrast Agent ◽  
Tumor Angiogenesis ◽  
Ultrasound Contrast Agent ◽  
Αvβ3 Integrin ◽  
Ultrasound Contrast ◽  
Targeted Ultrasound

New Trends in Molecular Imaging of Tumor Angiogenesis

2008 ◽  
Vol 8 (5) ◽  
pp. 497-522 ◽  
Author(s):  
Thomas Berthelot ◽  
Marie-Claire Lasne ◽  
Gerard Deleris
Keyword(s):  
Molecular Imaging ◽  
Tumor Angiogenesis

scholarly journals Ultrasound molecular imaging of tumor angiogenesis with a neuropilin-1-targeted microbubble

Biomaterials ◽  
2015 ◽  
Vol 56 ◽  
pp. 104-113 ◽  
Author(s):  
Hua Zhang ◽  
Sarah Tam ◽  
Elizabeth S. Ingham ◽  
Lisa M. Mahakian ◽  
Chun-Yen Lai ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Tumor Angiogenesis ◽  
Neuropilin 1 ◽  
Ultrasound Molecular Imaging

Micro-CT Molecular Imaging of Tumor Angiogenesis Using a Magnetite Nano-Cluster Probe

2013 ◽  
Vol 9 (6) ◽  
pp. 1041-1049 ◽  
Author(s):  
Ping Liu ◽  
Jing Li ◽  
Chunfu Zhang ◽  
Lisa X. Xu
Keyword(s):  
Molecular Imaging ◽  
Tumor Angiogenesis ◽  
Micro Ct ◽  
Nano Cluster

Molecular Imaging of Tumor Angiogenesis

2004 ◽  
Vol 1014 (1) ◽  
pp. 67-75 ◽  
Author(s):  
MICHAEL SCHIRNER ◽  
ANDREAS MENRAD ◽  
ANDREW STEPHENS ◽  
THOMAS FRENZEL ◽  
PETER HAUFF ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Tumor Angiogenesis

scholarly journals Molecular Imaging of Inducible VEGF Expression and Tumor Progression in a Breast Cancer Model

2017 ◽  
Vol 42 (1) ◽  
pp. 407-415 ◽  
Author(s):  
Lu Liang ◽  
Zhiwei Yue ◽  
Wei Du ◽  
Yang Li ◽  
Hongyan Tao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Imaging ◽  
Cell Survival ◽  
Real Time ◽  
Tumor Angiogenesis ◽  
Bioluminescence Imaging ◽  
Expression System ◽  
Cancer Model ◽  
Vegf Expression ◽  
Breast Cancer Model

Background: Tumor derived vascular endothelial growth factor (VEGF) can stimulate proliferation and migration of endothelial cells and recruit endothelial progenitor cells into tumors for vascular formation via a paracrine manner. Now increasing evidence suggests that VEGF also serves as an autocrine factor promoting cell survival and tumor angiogenesis. Real time visualization of VEGF activity in the early stages of tumor formation using molecular imaging will provide unprecedented insight into the biological processes of cancer. Methods: The mouse breast cancer cell line 4T1 was transfected with an inducible, bidirectional tetracycline (Bi-Tet) promoter driving VEGF and renilla luciferase (Rluc). This was used to quantitatively image conditional switching of VEGF by bioluminescence imaging (BLI) under the control of systemic administration of doxycycline. Simultaneously, 4T1 cells were labelled with the double fusion reporter gene (Fluc-eGFP) to establish a breast cancer model. Results: We found that inducible VEGF could promote proliferation and attenuate apoptosis due to oxidative stress in an autocrine manner in vitro. In vivo studies revealed that induction of VEGF expression during early tumor development not only dramatically enhanced tumor growth but also increased tumor angiogenesis as visualized by BLI. Finally, immunohistochemistry staining confirmed that inducing VEGF expression promoted cell survival and tumor neovascularization. Conclusion: Together the inducible bidirectional tetracycline (Bi-Tet) co-expression system combined with the dual bioluminescence imaging (BLI) system provides a platform to investigate a target gene’s role in the pathologic process of cancer and facilitates noninvasive monitoring of biological responses in real time.

scholarly journals Molecular Imaging of Tumor Angiogenesis

10.5772/32202 ◽  
2012 ◽  
Author(s):  
Shaunagh McDermott ◽  
Alexander Guimaraes
Keyword(s):  
Molecular Imaging ◽  
Tumor Angiogenesis

scholarly journals Molecular Imaging in Tumor Angiogenesis and Relevant Drug Research

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Xibo Ma ◽  
Jie Tian ◽  
Xin Yang ◽  
Chenghu Qin
Keyword(s):  
Computed Tomography ◽  
Molecular Imaging ◽  
Tumor Angiogenesis ◽  
Drug Research ◽  
Single Photon ◽  
Photon Emission ◽  
Region Of Interest ◽  
Emission Computed Tomography ◽  
Positron Emission ◽  
Novel Drug

Molecular imaging, including fluorescence imaging (FMI), bioluminescence imaging (BLI), positron emission tomography (PET), single-photon emission-computed tomography (SPECT), and computed tomography (CT), has a pivotal role in the process of tumor and relevant drug research. CT, especially Micro-CT, can provide the anatomic information for a region of interest (ROI); PET and SPECT can provide functional information for the ROI. BLI and FMI can provide optical information for an ROI. Tumor angiogenesis and relevant drug development is a lengthy, high-risk, and costly process, in which a novel drug needs about 10–15 years of testing to obtain Federal Drug Association (FDA) approval. Molecular imaging can enhance the development process by understanding the tumor mechanisms and drug activity. In this paper, we focus on tumor angiogenesis, and we review the characteristics of molecular imaging modalities and their applications in tumor angiogenesis and relevant drug research.

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