Diffusion Tensor Imaging of the Brain in Fetal Alcohol Spectrum Disorder

Author(s):  
Catherine Lebel ◽  
Carmen Rasmussen ◽  
Christian Beaulieu
2011 ◽  
Vol 35 (12) ◽  
pp. 2174-2183 ◽  
Author(s):  
Bruce S. Spottiswoode ◽  
Ernesta M. Meintjes ◽  
Adam W. Anderson ◽  
Christopher D. Molteno ◽  
Mark E. Stanton ◽  
...  

2018 ◽  
Vol 96 (2) ◽  
pp. 88-97 ◽  
Author(s):  
Yohaan Fernandes ◽  
Desire M. Buckley ◽  
Johann K. Eberhart

The term fetal alcohol spectrum disorder (FASD) refers to the entire suite of deleterious outcomes resulting from embryonic exposure to alcohol. Along with other reviews in this special issue, we provide insight into how animal models, specifically the zebrafish, have informed our understanding of FASD. We first provide a brief introduction to FASD. We discuss the zebrafish as a model organism and its strengths for alcohol research. We detail how zebrafish has been used to model some of the major defects present in FASD. These include behavioral defects, such as social behavior as well as learning and memory, and structural defects, disrupting organs such as the brain, sensory organs, heart, and craniofacial skeleton. We provide insights into how zebrafish research has aided in our understanding of the mechanisms of ethanol teratogenesis. We end by providing some relatively recent advances that zebrafish has provided in characterizing gene-ethanol interactions that may underlie FASD.


2021 ◽  
Vol 11 (13) ◽  
pp. 5961
Author(s):  
Vannessa Duarte ◽  
Paul Leger ◽  
Sergio Contreras ◽  
Hiroaki Fukuda

Fetal alcohol spectrum disorder (FASD) is an umbrella term for children’s conditions due to their mother having consumed alcohol during pregnancy. These conditions can be mild to severe, affecting the subject’s quality of life. An earlier diagnosis of FASD is crucial for an improved quality of life of children by allowing a better inclusion in the educational system. New trends in computer-based diagnosis to detect FASD include using Machine Learning (ML) tools to detect this syndrome. However, most of these studies rely on children’s images that can be invasive and costly. Therefore, this paper presents a study that focuses on evaluating an ANN to classify children with FASD using non-invasive and more accessible data. This data used comes from a battery of tests obtained from children, including psychometric, saccade eye movement, and diffusion tensor imaging (DTI). We study the different configurations of ANN with dense layers being the psychometric data that correctly perform the best with 75% of the outcome. The other models include a feature layer, and we used it to predict FASD using every test individually. Model obtained obtained an accuracy of 88.46% (psychometric, 74.07% (Antisaccadic), 72.24% (Prosaccadic), 88% (Memory guide saccade), and 75% (DTI). These results suggest that the ANN approach is a competitive and efficient methodology to detect FASD. These results are an improvement on Zhang’s 2019 model, which used the same data with less accuracy level.


2003 ◽  
Vol 8 (suppl_B) ◽  
pp. 48B-48B
Author(s):  
G Andrew ◽  
K Horne ◽  
M Reynolds ◽  
G Schuller ◽  
L Abele-Webster

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