L1-Type Cell Adhesion Molecules: Distinct Roles in Synaptic Targeting, Organization, and Function

2009 ◽  
pp. 247-263
Author(s):  
Smitha Babu Uthaman ◽  
Tanja Angela Godenschwege
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Synaptic Targeting ◽  
And Function

scholarly journals Expression and function of cell adhesion molecules during neural crest migration

2013 ◽  
Vol 373 (2) ◽  
pp. 244-257 ◽  
Author(s):  
Sonja J. McKeown ◽  
Adam S. Wallace ◽  
Richard B. Anderson
Keyword(s):  
Cell Adhesion ◽  
Neural Crest ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
And Function ◽  
Neural Crest Migration

Sertoli Cell Adhesion Molecules: Comparative Expression of Lselectin and Other Cams in Primary Cells And Immortalized Sertoli Cell Lines

1998 ◽  
Vol 4 (S2) ◽  
pp. 1068-1069
Author(s):  
Ann-Marie Broome ◽  
Clarke F. Millette
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Sertoli Cell ◽  
Cell Adhesion Molecules ◽  
Three Dimensional ◽  
Cell Interactions ◽  
Seminiferous Epithelium ◽  
Testicular Development ◽  
And Function ◽  
Cell Cell

Cell adhesion and cell adhesion molecules (CAMs) play a crucial role in testicular development and function. The seminiferous epithelium, the functional unit of the testis, represents a three dimensional architecture of supporting Sertoli cells (SC), and developing germ cells (GC). The seminiferous epithelium, therefore, must be receptive not only to individual cell growth and differentiation, but also to cell-cell interactions. Morphologically distinct cell-cell interactions occur between SC and GC and also between SC.[1] In general, these junctions can be categorized into three types: adhesive, occluding, and gap junctions. The orientation and function of these junctions are interaction dependent. For example, desmosome-like junctions (spot desmosomes) are found between SC and GC. These junctions are present in the basal and intermediate compartments of the testis and serve to translocate developing GC. SC-SC interactions, like the zonula occludens (tight junction), function as vectorial mediators, maintaining the blood-testis barrier and SC polarity.

scholarly journals Affinity requirements for control of synaptic targeting and neuronal cell survival by heterophilic IgSF cell adhesion molecules

2021 ◽  
Author(s):  
Shuwa Xu ◽  
Alina P Sergeeva ◽  
Phinikoula S. Katsamba ◽  
Seetha Mannepalli ◽  
Fabiana Bahna ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Cell Survival ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Gene Copy Number ◽  
Neuronal Cell ◽  
Gene Copy ◽  
Loss Of Function ◽  
Synaptic Targeting

SUMMARYNeurons in the developing brain express many different cell adhesion molecules (CAMs) on their surfaces, and CAM interactions are essential for the determination of synaptic connectivity patterns. CAM binding affinities can vary by more than 200-fold, but the significance of affinity differences among CAMs is unknown. Here we provide a systematic characterization of the in vivo consequences of altering CAM affinity. Interactions between DIP-α and its binding partners Dpr6 and Dpr10 control synaptic targeting and cell survival for Drosophila optic lobe neurons. We generated mutations that change DIP-α::Dpr10 binding affinity and introduced these into the endogenous loci. We show that cell survival and synaptic targeting have different affinity requirements, and that there is a threshold affinity required for targeting. Reducing affinity causes graded loss-of-function phenotypes, while increasing affinity rescues cells that would normally die. Affinity reduction can be compensated for by increasing gene copy number.

Structure and function of cell adhesion molecules

1999 ◽  
Vol 106 (4) ◽  
pp. 467-476 ◽  
Author(s):  
Lilli Petruzzelli ◽  
Mimi Takami ◽  
H.David Humes
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Structure And Function ◽  
And Function
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