Glucan Particles: Choosing the Appropriate Size to Use as a Vaccine Adjuvant

2021 ◽  
pp. 269-280
Author(s):  
Mariana Colaço ◽  
João Panão Costa ◽  
Olga Borges
Keyword(s):  
Vaccine Adjuvant

The Application and Functional Progress of γ-Poly-Glutamic Acid in Food: A Mini-Review

2020 ◽  
Vol 26 (41) ◽  
pp. 5347-5352
Author(s):  
Guoliang Wang ◽  
Qing Liu ◽  
Ying Wang ◽  
Jingyuan Li ◽  
Yue Chen ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Food Industry ◽  
Water Solubility ◽  
Drug Carrier ◽  
Physical Property ◽  
Coating Material ◽  
Vaccine Adjuvant ◽  
Food Ingredient ◽  
Naturally Occurring

γ-Poly-glutamic acid (γ-PGA) is a naturally occurring homo-polyamide produced by various strains of Bacillus. As a biopolymer substance, γ-PGA possesses a few predominant features containing good water solubility, biocompatibility, degradability and non-toxicity. Based on this, γ-PGA can be used in pharmaceutical, such as drug carrier/deliverer, vaccine adjuvant, and coating material for microencapsulation, etc. Moreover, it has also been applied in a broad range of industrial fields including food, medicine, bioremediation, cosmetics, and agriculture. Especially, γ-PGA is an extremely promising food ingredient. In this mini-review, our aim is to review the function and application progress of γ-PGA in the food industry: e.g., improving taste and flavor, enhancing physical property, and promoting health.

Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles

2021 ◽  
Author(s):  
Deepender Kaushik ◽  
Arshpreet Kaur ◽  
Nikolai Petrovsky ◽  
Deepak B. Salunke
Keyword(s):  
Structural Evolution ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Vaccine Adjuvant ◽  
Toll Like Receptor ◽  
Detailed Structure ◽  
Structure Activity

TLR7/8 agonists are emerging as promising vaccine adjuvant candidates. An evolution of imidazole based TLR7/8 agonist from imidazoquinoline based scaffold is delineated along with the elaboration of detailed structure activity relationship (SAR) in each chemotype.

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