Catecholamine Sulfates and Platelet Phenolsulfotransferase (PST) Activity in Human Hypertension

1981 ◽  
pp. 175-185 ◽  
Author(s):  
O. Kuchel ◽  
N. T. Buu ◽  
P. Hamet ◽  
P. Larochelle ◽  
M. Bourque
Keyword(s):  
Human Hypertension

Monogenic forms of human hypertension

2002 ◽  
Vol 22 (2) ◽  
pp. 81-88 ◽  
Author(s):  
Hakan R. Toka ◽  
Friedrich C. Luft
Keyword(s):  
Human Hypertension

Mechanisms of Coronary Flow Reserve Impairment in Human Hypertension

Hypertension ◽  
1997 ◽  
Vol 29 (2) ◽  
pp. 551-559 ◽  
Author(s):  
Michaela Kozàkovà ◽  
Carlo Palombo ◽  
Lorenza Pratali ◽  
Giuseppe Pittella ◽  
Fabio Galetta ◽  
...  
Keyword(s):  
Coronary Flow Reserve ◽  
Coronary Flow ◽  
Human Hypertension ◽  
Flow Reserve

Divergent Effects of Dihydropyridine and Phenylalkylamine Calcium Channel Antagonist Classes on Autonomic Function in Human Hypertension

Hypertension ◽  
1995 ◽  
Vol 26 (1) ◽  
pp. 143-149 ◽  
Author(s):  
Mala T. Kailasam ◽  
Robert J. Parmer ◽  
Justine H. Cervenka ◽  
Regina A. Wu ◽  
Michael G. Ziegler ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Antagonist ◽  
Autonomic Function ◽  
Human Hypertension

scholarly journals Further evidence against the role renal medullary perfusion in short-term control of arterial pressure in normotensive and mildly or overtly hypertensive rats

2021 ◽  
Vol 473 (4) ◽  
pp. 623-631
Author(s):  
Bożena Bądzyńska ◽  
Iwona Baranowska ◽  
Janusz Sadowski
Keyword(s):  
Arterial Pressure ◽  
Renal Excretion ◽  
Sodium Concentration ◽  
Sprague Dawley ◽  
Hypertensive Rats ◽  
Critical Determinant ◽  
Human Hypertension ◽  
Pressure Elevation ◽  
Doppler Probe ◽  
Medullary Tissue

AbstractEarlier evidence from studies of rat hypertension models undermines the widespread view that the rate of renal medullary blood flow (MBF) is critical in control of arterial pressure (MAP). Here, we examined the role of MBF in rats that were normotensive, with modest short-lasting pressure elevation, or with overt established hypertension. The groups studied were anaesthetised Sprague-Dawley rats: (1) normotensive, (2) with acute i.v. norepinephrine-induced MAP elevation, and (3) with hypertension induced by unilateral nephrectomy followed by administration of deoxycorticosterone-acetate (DOCA) and 1% NaCl drinking fluid for 3 weeks. MBF was measured (laser-Doppler probe) and selectively increased using 4-h renal medullary infusion of bradykinin. MAP, renal excretion parameters and post-experiment medullary tissue osmolality and sodium concentration were determined. In the three experimental groups, baseline MAP was 117, 151 and 171 mmHg, respectively. Intramedullary bradykinin increased MBF by 45%, 65% and 70%, respectively, but this was not associated with a change in MAP. In normotensive rats a significant decrease in medullary tissue sodium was seen. The intramedullary bradykinin specifically increased renal excretion of water, sodium and total solutes in norepinephrine-treated rats but not in the two other groups. As previously shown in models of rat hypertension, in the normotensive rats and those with acute mild pressure elevation (resembling labile borderline human hypertension), 4-h renal medullary hyperperfusion failed to decrease MAP. Nor did it decrease in DOCA-salt model mimicking low-renin human hypertension. Evidently, within the 4-h observation, medullary perfusion was not a critical determinant of MAP in normotensive and hypertensive rats.

Peripheral blood mononuclear cell-endothelial adhesion in human hypertension following exercise

2000 ◽  
Vol 18 (12) ◽  
pp. 1801-1806 ◽  
Author(s):  
Paul J Mills ◽  
Alan S. Maisel ◽  
Michael G Ziegler ◽  
Joel E. Dimsdale ◽  
Steve Carter ◽  
...  
Keyword(s):  
Peripheral Blood Mononuclear Cell ◽  
Mononuclear Cell ◽  
Peripheral Blood ◽  
Peripheral Blood Mononuclear ◽  
Human Hypertension

Free and Conjugated Catecholamines in Human Hypertension

1978 ◽  
Vol 55 (s4) ◽  
pp. 77s-80s ◽  
Author(s):  
O. Kuchel ◽  
N. T. Buu ◽  
TH. Unger ◽  
J. Genest
Keyword(s):  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Primary Aldosteronism ◽  
Adrenal Vein ◽  
Elevated Plasma ◽  
Hypertensive Patients ◽  
Human Hypertension ◽  
Control Subjects ◽  
Urinary Dopamine ◽  
Noradrenaline And Adrenaline

1. Noradrenaline and adrenaline in the adrenal vein of essential hypertensive patients are almost exclusively (99%) unconjugated or free. However only 17% of dopamine is free, the rest is conjugated. The further the site of sampling from the adrenal vein the closer come the free catecholamines to their normal peripheral venous proportion (noradrenaline + adrenaline 20%, dopamine less than 1% of total catecholamines). Deviations from these patterns help to detect the site and type of secretion of phaeochromocytoma. 2. Essential hypertensive patients have, compared with control subjects, higher conjugated plasma dopamine, less urinary free and conjugated dopamine with blunted urinary free dopamine and sodium responsiveness to frusemide. Conjugated noradrenaline + adrenaline, mean arterial pressure and age are positively interrelated. 3. Patients with primary aldosteronism have elevated plasma and urinary total dopamine. After removal of the adenoma urinary dopamine excretion decreases to normal. 4. Elevated conjugated dopamine appears to reflect a compensatory activation of the dopaminergic vasodilator pathway in hypertension, the total urinary dopamine excretion an intrinsic deficiency or compensatory increase of a dopamine-modulated natriuretic mechanism.

scholarly journals Relation of myocardial fibrosis to circulating aldosterone and endothelin in primary and secondary human hypertension: an ultrasonic study by acoustic densitometry

2002 ◽  
Vol 39 ◽  
pp. 249 ◽  
Author(s):  
Michaela Kozakova ◽  
Simona Buralli ◽  
Carlo Palombo ◽  
Angelica Moretti ◽  
Giampaolo Bernini ◽  
...  
Keyword(s):  
Myocardial Fibrosis ◽  
Human Hypertension ◽  
Ultrasonic Study
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