Divergent Effects of Dihydropyridine and Phenylalkylamine Calcium Channel Antagonist Classes on Autonomic Function in Human Hypertension

Hypertension ◽  
1995 ◽  
Vol 26 (1) ◽  
pp. 143-149 ◽  
Author(s):  
Mala T. Kailasam ◽  
Robert J. Parmer ◽  
Justine H. Cervenka ◽  
Regina A. Wu ◽  
Michael G. Ziegler ◽  
...  
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Antagonist ◽  
Autonomic Function ◽  
Human Hypertension

scholarly journals The Mibefradil Derivative NNC55-0396, a Specific T-Type Calcium Channel Antagonist, Exhibits Less CYP3A4 Inhibition than Mibefradil

2008 ◽  
Vol 36 (7) ◽  
pp. 1291-1299 ◽  
Author(s):  
Peter H. Bui ◽  
Arnulfo Quesada ◽  
Adrian Handforth ◽  
Oliver Hankinson
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Antagonist ◽  
Cyp3a4 Inhibition

Effects of Lomerizine, a Calcium Channel Antagonist, on Retinal and Optic Nerve Head Circulation in Rabbits and Humans

2003 ◽  
Vol 44 (11) ◽  
pp. 4864 ◽  
Author(s):  
Yasuhiro Tamaki ◽  
Makoto Araie ◽  
Yasuhiro Fukaya ◽  
Miyuki Nagahara ◽  
Asuka Imamura ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Calcium Channel ◽  
Optic Nerve Head ◽  
Calcium Channel Antagonist ◽  
Optic Nerve Head Circulation

scholarly journals Comparison of the effects of L-type calcium channel antagonist Amlodipine with L/N-type calcium channel antagonist Cilnidipine on blood pressure, heart rate, proteinuria and lipid profile in hypertensive patients

2016 ◽  
Vol 15 (3) ◽  
pp. 460-465
Author(s):  
Kiran Kumar Singal ◽  
Neerja Singal ◽  
Abhinav Gupta ◽  
Akash Garg ◽  
Ravi Kumar
Keyword(s):  
Blood Pressure ◽  
Calcium Channel ◽  
Calcium Channel Antagonist ◽  
Total Cholesterol Level ◽  
Medical Science ◽  
Reflex Tachycardia ◽  
Before And After ◽  
Voltage Dependent ◽  
Amlodipine Group ◽  
Voltage Dependent Calcium Channels

Background: Cilnidipine is a novel and unique 1,4-dydropyridine derivative calcium antagonist that exerts potent inhibitory actions not only on L-type but also on N-type voltage dependent calcium channels. Blockade of the neural N-type calcium channel inhibits the secretion of norepinephrine from peripheral neural terminals and depresses sympathetic nervous system activity.Objective and methods: The purpose of this study was to assess the effect of Cilnidipine and Amlodipine on blood pressure (BP) levels. We did BP monitoring before and after once-daily use of Cilnidipine and Amlodipine in 100 hypertensive patients.Results: Both drugs significantly reduced systolic BP (SBP) and diastolic BP (DBP). However, the reductions in pulse rate (PR) were significantly greater in the Cilnidipine group than the Amlodipine group. N-type calcium channel blockade by Cilnidipine may not cause reflex tachycardia, and may be useful for hypertensive treatment.Conclusion: There was significant reduction in proteinuria with Clindipine as compared to Amlodipine. However, there were no significant change in total cholesterol level in diabetes and non-diabetics in both the group.Bangladesh Journal of Medical Science Vol.15(3) 2016 p.460-465

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