GABA receptors and related binding sites

1984 ◽  
pp. 179-183
Author(s):  
G. A. R. Johnston ◽  
R. D. Allan ◽  
A. D. Benton ◽  
S. Chen Chow ◽  
C. A. Drew ◽  
...  
Keyword(s):  
Binding Sites ◽  
Gaba Receptors

The Benzodiazepine Receptor and its Role in Anxiety

1988 ◽  
Vol 152 (5) ◽  
pp. 599-600 ◽  
Author(s):  
Sandra E. File
Keyword(s):  
Binding Sites ◽  
Gaba Receptors ◽  
Benzodiazepine Receptor ◽  
Primary Site ◽  
Affinity Binding ◽  
High Affinity Binding ◽  
Inhibitory Neurotransmitter ◽  
High Affinity ◽  
Site Of Action ◽  
The Brain

Ten years ago, specific high-affinity binding sites for benzodiazepines (BDZs) were found in the brain (Mohler & Okada, 1977; Squires & Braestrup, 1977). These binding sites are believed to be the primary site of action of BDZs and are found on the same protein as GABA receptors. GABA is the main inhibitory neurotransmitter in the brain.

Dihydropicrotoxinin binding sites in rat brain: comparison to GABA receptors

1978 ◽  
Vol 150 (3) ◽  
pp. 642-647 ◽  
Author(s):  
M.K. Ticku ◽  
P.C. Van Ness ◽  
J.W. Haycock ◽  
W.B. Levy ◽  
R.W. Olsen
Keyword(s):  
Rat Brain ◽  
Binding Sites ◽  
Gaba Receptors

Conformation of Ribosomes from Escherichia Coli

1974 ◽  
Vol 32 ◽  
pp. 210-211
Author(s):  
M. Boublik ◽  
W. Hellmann ◽  
F. Jenkins
Keyword(s):  
Binding Sites ◽  
Ribosomal Proteins ◽  
Fluorescent Dyes ◽  
Protein Biosynthesis ◽  
Three Dimensional ◽  
Spatial Arrangement ◽  
Dimensional Structure ◽  
Complete Understanding ◽  
And Function

The present knowledge of the three-dimensional structure of ribosomes is far too limited to enable a complete understanding of the various roles which ribosomes play in protein biosynthesis. The spatial arrangement of proteins and ribonuclec acids in ribosomes can be analysed in many ways. Determination of binding sites for individual proteins on ribonuclec acid and locations of the mutual positions of proteins on the ribosome using labeling with fluorescent dyes, cross-linking reagents, neutron-diffraction or antibodies against ribosomal proteins seem to be most successful approaches. Structure and function of ribosomes can be correlated be depleting the complete ribosomes of some proteins to the functionally inactive core and by subsequent partial reconstitution in order to regain active ribosomal particles.

Electron Probe Analysis of Muscle

1982 ◽  
Vol 40 ◽  
pp. 398-401
Author(s):  
A. V. Somlyo ◽  
H. Shuman ◽  
A. P. Somlyo
Keyword(s):  
Skeletal Muscle ◽  
Smooth Muscle ◽  
Sarcoplasmic Reticulum ◽  
Resting State ◽  
Binding Sites ◽  
Electron Probe ◽  
Frog Skeletal Muscle ◽  
Electron Probe Analysis ◽  
Probe Analysis

Electron probe analysis of frozen dried cryosections of frog skeletal muscle, rabbit vascular smooth muscle and of isolated, hyperpermeab1 e rabbit cardiac myocytes has been used to determine the composition of the cytoplasm and organelles in the resting state as well as during contraction. The concentration of elements within the organelles reflects the permeabilities of the organelle membranes to the cytoplasmic ions as well as binding sites. The measurements of [Ca] in the sarcoplasmic reticulum (SR) and mitochondria at rest and during contraction, have direct bearing on their role as release and/or storage sites for Ca in situ.

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