Quantitative Histochemical Approaches to Energy Metabolism in Nervous Tissue

1973 ◽  
pp. 235-244
Author(s):  
G. M. Lehrer ◽  
H. S. Maker
Keyword(s):  
Energy Metabolism ◽  
Nervous Tissue

Methods of Fixation of Nervous Tissue for Use in the Study of Cerebral Energy Metabolism

2003 ◽  
pp. 1-42 ◽  
Author(s):  
W. David Lust ◽  
Anthony J. Ricci ◽  
Warren R. Seltian ◽  
Robert A. Ratcheson
Keyword(s):  
Energy Metabolism ◽  
Nervous Tissue ◽  
Cerebral Energy Metabolism

scholarly journals Glycolysis intensity and activities of energy metabolism enzymes in the rat brain during repeated exposure to hypoglycemic doses of insulin

1994 ◽  
Vol 40 (5) ◽  
pp. 53-54 ◽  
Author(s):  
P. K. Telushkin ◽  
P. P. Potapov
Keyword(s):  
Diabetes Mellitus ◽  
Energy Metabolism ◽  
Rat Brain ◽  
Nervous Tissue ◽  
Krebs Cycle ◽  
Pathological Features ◽  
Metabolism Enzymes ◽  
Insulin Coma ◽  
Treatment Of Diabetes ◽  
The Brain

Renewable conditions of hypoglycemia are a frequent complication in the treatment of diabetes mellitus, determine the clinic of pancreatic insulinomas, are observed in diseases of the kidneys, liver, gastrointestinal tract and alcoholism, leading to the development of posthypoglycemic encephalopathy. At the same time, a single, even severe, insulin coma is accompanied by reversible metabolic changes in the brain. Therefore, the pathological features of metabolism in the nervous tissue, which are the result of repeated hypoglycemia, in particular possible disturbances in energy metabolism, require further study. In this work, we studied the main ways of glucose metabolism - the intensity of glycolysis and glycogenolysis, the activity of Krebs cycle dehydrogenases, alanine and aspartate aminotransferases in the rat brain in setting of multiple hypoglycemia.

Transmitter mediated regulation of energy metabolism in nervous tissue at the cellular level

1986 ◽  
Vol 9 (1) ◽  
pp. 1-10 ◽  
Author(s):  
V PENTREATH ◽  
L SEAL ◽  
J MORRISON ◽  
P MAGISTRETTI
Keyword(s):  
Energy Metabolism ◽  
Nervous Tissue ◽  
Cellular Level

Mitochondrial matrix calcium ions regulate energy production in myocardium: A cytochemical study

1990 ◽  
Vol 48 (2) ◽  
pp. 166-167
Author(s):  
W.A. Jacob ◽  
R. Hertsens ◽  
A. Van Bogaert ◽  
M. De Smet
Keyword(s):  
Energy Metabolism ◽  
Calcium Ions ◽  
Energy Production ◽  
Regulation Of Respiration ◽  
Free Calcium ◽  
Mitochondrial Matrix ◽  
Cytochemical Study ◽  
Nmr Techniques

In the past most studies of the control of energy metabolism focus on the role of the phosphorylation potential ATP/ADP.Pi on the regulation of respiration. Studies using NMR techniques have demonstrated that the concentrations of these compounds for oxidation phosphorylation do not change appreciably throughout the cardiac cycle and during increases in cardiac work. Hence regulation of energy production by calcium ions, present in the mitochondrial matrix, has been the object of a number of recent studies.Three exclusively intramitochondnal dehydrogenases are key enzymes for the regulation of oxidative metabolism. They are activated by calcium ions in the low micromolar range. Since, however, earlier estimates of the intramitochondnal calcium, based on equilibrium thermodynamic considerations, were in the millimolar range, a physiological correlation was not evident. The introduction of calcium-sensitive probes fura-2 and indo-1 made monitoring of free calcium during changing energy metabolism possible. These studies were performed on isolated mitochondria and extrapolation to the in vivo situation is more or less speculative.

Association of pituitary adenoma with neuronal christoma: A TEM study

1994 ◽  
Vol 52 ◽  
pp. 232-233
Author(s):  
Eva Horvath ◽  
Kalman Kovacs ◽  
B. W. Scheithauer ◽  
R. V. Lloyd ◽  
H. S. Smyth
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Pituitary Tumor ◽  
Nervous Tissue ◽  
Alternative Explanation ◽  
Growth Hormone Releasing Hormone ◽  
Cell Hyperplasia ◽  
Releasing Hormone ◽  
Secretory Neurons

The association of a pituitary adenoma with nervous tissue consisting of neuron-like cells and neuropil is a rare abnormality. In the majority of cases, the pituitary tumor is a chromophobic adenoma, accompanied by acromegaly. Histology reveals widely variable proportions of endocrine and nervous tissue in alternating or intermingled patterns. The lesion is perceived as a composite one consisting of two histogenetically distinct parts. It has been suggested that the neuronal component, morphologically similar to secretory neurons of the hypothalamus, may initiate adenoma formation by releasing stimulatory substances. Immunoreactivity for growth hormone releasing hormone (GRH) in the neuronal component of some cases supported this view, whereas other findings such as consistent lack of growth hormone (GH) cell hyperplasia in the lesions called for alternative explanation.Fifteen tumors consisting of a pituitary adenoma and a neuronal component have been collected over a 20 yr. period. Acromegaly was present in 11 patients, was equivocal in one, and absent in 3.

Sign in / Sign up

Export Citation Format

Share Document