New role of bile acid metabolism in intestinal bacteria translocation

2008 ◽  
pp. 83-91
Author(s):  
M. Petruzzelli ◽  
A. Moschetta
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Intestinal Bacteria ◽  
Bile Acid Metabolism

scholarly journals Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Qin Cao ◽  
Zhongzhong Liu ◽  
Yan Xiong ◽  
Zibiao Zhong ◽  
Qifa Ye
Keyword(s):  
Lipid Metabolism ◽  
Bile Acid ◽  
Inflammatory Response ◽  
Acid Metabolism ◽  
Membrane Lipid ◽  
Multiple Roles ◽  
Bile Acid Metabolism ◽  
Radical Process ◽  
Underlying Mechanisms

As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind of cholesterol metabolite produced by enzymatic or radical process, oxysterols have drawn much attention in the last decades. Among which, the role of 25-hydroxycholesterol (25-HC) in cholesterol and bile acid metabolism, antivirus process, and inflammatory response has been largely disclosed. This review is aimed at revealing these functions and underlying mechanisms of 25-HC.

scholarly journals Effects of long-term ingestion of difructose anhydride III (DFA III) on intestinal bacteria and bile acid metabolism in humans

2006 ◽  
Vol 101 (2) ◽  
pp. 149-156 ◽  
Author(s):  
Kimiko Minamida ◽  
Chikako Asakawa ◽  
I Nengah Sujaya ◽  
Maki Kaneko ◽  
Ayumi Abe ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Intestinal Bacteria ◽  
Bile Acid Metabolism ◽  
Dfa Iii

scholarly journals Dysfunction of Organic Anion Transporting Polypeptide 1a1 Alters Intestinal Bacteria and Bile Acid Metabolism in Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e34522 ◽  
Author(s):  
Youcai Zhang ◽  
Pallavi B. Limaye ◽  
Lois D. Lehman-McKeeman ◽  
Curtis D. Klaassen
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Organic Anion ◽  
Intestinal Bacteria ◽  
Bile Acid Metabolism ◽  
Organic Anion Transporting Polypeptide

scholarly journals Risk Modification of Colorectal Adenoma by CYP7A1 Polymorphisms and the Role of Bile Acid Metabolism in Carcinogenesis

2011 ◽  
Vol 5 (2) ◽  
pp. 197-204 ◽  
Author(s):  
Betsy C. Wertheim ◽  
Jeffrey W. Smith ◽  
Changming Fang ◽  
David S. Alberts ◽  
Peter Lance ◽  
...  
Keyword(s):  
Bile Acid ◽  
Colorectal Adenoma ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Risk Modification

scholarly journals The Role of the Gut Microbiota in Bile Acid Metabolism

2017 ◽  
Vol 16 ◽  
pp. S21-S26 ◽  
Author(s):  
Oscar Ramírez-Pérez ◽  
Vania Cruz-Ramón ◽  
Paulina Chinchilla-López ◽  
Nahum Méndez-Sánchez
Keyword(s):  
Bile Acid ◽  
Gut Microbiota ◽  
Acid Metabolism ◽  
Bile Acid Metabolism

The role of gastric lipolysis on fat absorption and bile acid metabolism in the rat

Lipids ◽  
1979 ◽  
Vol 14 (9) ◽  
pp. 811-815 ◽  
Author(s):  
C. C. Roy ◽  
M. Roulet ◽  
D. Lefebvre ◽  
L. Chartrand ◽  
G. Lepage ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Fat Absorption

scholarly journals A9 BACTERIAL BILE SALT HYDROLASE GENE ABUNDANCE IS ASSOCIATED WITH RORC GENE EXPRESSION IN INTESTINAL MUCOSA OF INFLAMMATORY DISEASE PATIENTS

2020 ◽  
Vol 3 (Supplement_1) ◽  
pp. 11-12
Author(s):  
C Hernandez-Rocha ◽  
K Borowski ◽  
W Turpin ◽  
M Smith ◽  
J Stempak ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bile Acid ◽  
Bile Acids ◽  
Acid Metabolism ◽  
Bile Acid Metabolism ◽  
Bile Salt Hydrolase ◽  
Host Gene Expression ◽  
Biopsy Site ◽  
Endoscopic Score

Abstract Background The role of gut microbes involved in bile acid metabolism and their impact on mucosal immune regulation is beginning to be appreciated. For instance, changes in microbial bile salt hydrolase (BSH) activity which deconjugates bile acids in the gastrointestinal tract of gnotobiotic mice, significantly alters gene expression patterns of immune-related genes in ileum. Moreover, bile acid dysmetabolism may participate in the chronic inflammation loop of Inflammatory bowel disease (IBD). Aims We carried out an integrated mucosal microbiome-transcriptome analysis to elucidate associations between microbial bile-acid metabolizing function and host gene expression. Methods Crohn’s disease (CD), ulcerative colitis (UC) and IBD unclassified (IBDU) patients were recruited prior to scheduled colonoscopy performed as part of clinical care. Only patients with non-inflamed mucosa defined as a segmental simple endoscopic score 0–2 in CD and a segmental Mayo endoscopic score of 0 in UC/IBDU were included in this analysis to minimize the effect of inflammation on gene expression. Biopsy samples were obtained from terminal ileum, ascending colon and sigmoid colon, and microbial DNA and human RNA was extracted. V4 region of 16S rRNA gene was sequenced and the relative abundance of bile acid-metabolizing genes was inferred using PICRUSt. RNA-seq was used to sequence total human RNA and a supervised transcript reduction analysis focus upon 65 genes previously associated with bile acid metabolism and IBD was utilized. Associations between microbiome clusters of orthologous groups (COGs), transcriptome, diagnosis (CD vs UC/IBDU), and biopsy site were analyzed using linear mixed-effects model with lmer4 function in R. An adjusted-p value after false discovery rate correction < 0.05 was considered significant. Results A total of 126 samples from 86 subjects were analyzed corresponding to 35 CD and 51 UC/IBDU. Mean age for the total cohort was 34.7 ± 11 years and 35 (40.6%) were females. There was a significant negative correlation between relative abundance of bacterial bsh genes (COG3049) and human RORC gene (p < 0.03). This association was independent of type of diagnosis and biopsy site. There was no association among other analyzed bacterial COGs and host genes. Conclusions Using an integrative microbiome-host transcriptome approach, our data provide new evidence linking microbial bile acid deconjugation (bsh genes) and host gene expression in the mucosal-luminal interface in quiescent IBD-affected tissue. Nuclear receptor RORC is pivotal in the differentiation and function of innate lymphoid cells and T-helper 17 cells. Modulation of this pathway by bile acids or gut bacteria involved in their metabolism could shed light on the immune role of bile acids in IBD patients. Funding Agencies CAG, CIHRNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Sign in / Sign up

Export Citation Format

Share Document