The Role of Serine/Threonine Protein Phosphatases in Ceramide Signaling

2002 ◽  
pp. 49-61
Author(s):  
Charles E. Chalfant ◽  
Yusuf A. Hannun
Keyword(s):  
Protein Phosphatases

Role of protein phosphatases in the regulation of nitrogen nutrition in plants

2021 ◽  
Author(s):  
Lekshmy Sathee ◽  
G. K. Krishna ◽  
Sandeep B. Adavi ◽  
Shailendra K. Jha ◽  
Vanita Jain
Keyword(s):  
Nitrogen Nutrition ◽  
Protein Phosphatases

scholarly journals Evidence for a role of protein phosphatases 1 and 2A during early nephrogenesis

1995 ◽  
Vol 48 (1) ◽  
pp. 103-110 ◽  
Author(s):  
Johan Svennilson ◽  
Madeleine Durbeej ◽  
Gianni Celsi ◽  
Åsa Laestadius ◽  
Edgar F. da Cruz e Silva ◽  
...  
Keyword(s):  
Protein Phosphatases

scholarly journals The role of brain protein phosphatases 1 and 2A in the regulation of microtubule formation

1987 ◽  
Vol 43 ◽  
pp. 203
Author(s):  
Hideyuki Yamamoto ◽  
Yoshiki Saitoh ◽  
Eishichi Miyamoto
Keyword(s):  
Protein Phosphatases ◽  
Brain Protein ◽  
Microtubule Formation

scholarly journals Protein Phosphatases in G1 Regulation

2020 ◽  
Vol 21 (2) ◽  
pp. 395 ◽  
Author(s):  
Ruth Martín ◽  
Vilte Stonyte ◽  
Sandra Lopez-Aviles
Keyword(s):  
Cell Cycle ◽  
Protein Phosphatases ◽  
Eukaryotic Cells ◽  
Signalling Pathways ◽  
Cyclin Dependent Kinase ◽  
Restriction Point ◽  
Environmental Signals ◽  
Substrate Phosphorylation ◽  
Cell Cycle Machinery

Eukaryotic cells make the decision to proliferate, to differentiate or to cease dividing during G1, before passage through the restriction point or Start. Keeping cyclin-dependent kinase (CDK) activity low during this period restricts commitment to a new cell cycle and is essential to provide the adequate timeframe for the sensing of environmental signals. Here, we review the role of protein phosphatases in the modulation of CDK activity and as the counteracting force for CDK-dependent substrate phosphorylation, in budding and fission yeast. Moreover, we discuss recent findings that place protein phosphatases in the interface between nutritional signalling pathways and the cell cycle machinery.

The role of protein kinases and protein phosphatases in the regulation of cardiac sarcoplasmic reticulum function

1988 ◽  
Vol 82 (1-2) ◽  
Author(s):  
EvangeliaG. Kranias ◽  
RameshC. Gupta ◽  
Gyorgyi Jakab ◽  
HaeWon Kim ◽  
NancyA.E. Steenaart ◽  
...  
Keyword(s):  
Sarcoplasmic Reticulum ◽  
Protein Kinases ◽  
Protein Phosphatases ◽  
Cardiac Sarcoplasmic Reticulum

Characterization of serine/threonine protein phosphatases in RINm5F insulinoma cells

1993 ◽  
Vol 13 (6) ◽  
pp. 349-358 ◽  
Author(s):  
Åke Sjöhom ◽  
Richard E. Honkanen ◽  
Per-Olof Berggren
Keyword(s):  
Okadaic Acid ◽  
Potent Inhibitor ◽  
Protein Phosphatases ◽  
Marine Sponges ◽  
Rinm5f Cell ◽  
Ic50 Values ◽  
Marine Dinoflagellates ◽  
Insulinoma Cells

This study investigates the occurrence and regulation of serine/threonine protein phosphatases (PPases) in insulin-secreting RINm5F insulinoma cells. PPases types 1 and 2A were identified in crude RINm5F cell homogenates by both enzymatic assay and Western blot analysis. We then characterized and compared the inhibitory actions of several compounds isolated from cyanobacteria, marine dinoflagellates and marine sponges, (viz. okadaic acid, microcystin-LR, calyculin-A and nodularin) cation-independent PPase activities in RINm5F cell homogenates. It was found that okadaic acid was the least potent inhibitor (IC50 ≈ 10−9M, IC100 ≈ 10−6M), while the other compounds exhibited IC50 values of ≈ 5·10−10 M and IC100 ≈ 5·10−9 M. The findings indicate that the inhibitory substances employed in this study may be used pharmacologically to investigate the role of serine/threonine PPases in RINm5F cell insulin secretion, a process that is likely to be regulated to a major extent by protein phosphorylation.

scholarly journals Role of Protein Phosphatases in Cyclic AMP-mediated Stimulation of Hepatic Na+/Taurocholate Cotransport

1998 ◽  
Vol 273 (45) ◽  
pp. 30039-30045 ◽  
Author(s):  
Sunil Mukhopadhyay ◽  
Cynthia R. L. Webster ◽  
M. Sawkat Anwer
Keyword(s):  
Cyclic Amp ◽  
Protein Phosphatases ◽  
Stimulation Of

scholarly journals Searching for the role of protein phosphatases in eukaryotic microorganisms

1999 ◽  
Vol 32 (7) ◽  
pp. 835-839 ◽  
Author(s):  
A.M. da-Silva ◽  
P.D.A. Zapella ◽  
L.P.M. Andrioli ◽  
R.B. Campanhã ◽  
L.C. Fiorini ◽  
...  
Keyword(s):  
Protein Phosphatases ◽  
Eukaryotic Microorganisms
Sign in / Sign up

Export Citation Format

Share Document