Enzyme Therapy in Chronic Pancreatitis

1999 ◽  
pp. 189-198
Author(s):  
P. Layer ◽  
J. Keller
Keyword(s):  
Chronic Pancreatitis ◽  
Enzyme Therapy

scholarly journals Evaluation of Substitution Enzyme Therapy of Exocrine Pancreatic Insufficiency of Pancreatic Gland in Patients with Diabetes Mellitus and Chronic Pancreatitis

2020 ◽  
Vol 5 (6) ◽  
pp. 163-169
Author(s):  
Ye. S. Sirchak ◽  
◽  
V. Ye. Barani
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Pancreatitis ◽  
Lipase Activity ◽  
Pancreatic Insufficiency ◽  
Exocrine Pancreatic Insufficiency ◽  
Enzyme Therapy ◽  
Breath Tests ◽  
Patients With Diabetes ◽  
Main Meal

The study of the combined course of chronic pancreatitis and diabetes mellitus present a particular interest. The purpose of the study was to determine the effectiveness of correction of exocrine pancreatic insufficiency of the pancreas in patients with chronic pancreatitis and diabetes mellitus types 1 and 2 with using of different forms and doses of polyenzyme drugs. Material and methods. 126 patients with diabetes mellitus and chronic pancreatitis were examined. The patients were divided into 2 groups: 1 group included 62 patients with type 1 diabetes mellitus, and 2 group comprised 64 patients with type 2 diabetes. All surveyed patients underwent general clinical, anthropometric, instrumental and laboratory methods of investigation. Patients of both groups were divided into subgroups depending on the method of correction of exocrine pancreatic insufficiency, namely 1.1 and 2.1 subgroups received tableted polyenzyme preparation with minimal lipase activity of 10000 IU as enzyme therapy, and 1.2 and 2.2 subgroups received mini-tableted polyenzyme preparation with minimal lipase activity of 25000 IU. Results and discussion. The use of mini-tableted polyenzyme preparation with minimal lipase activity of 25000 IU according to the results of C13-mixed triglyceride and C13-amylase breath tests was an effective method for the correction of exocrine insufficiency of the pancreas in patients with chronic pancreatitis and diabetes mellitus types 1 and 2. We detected a statistically significant increase of the maximally concentration of 13CO2 between 150 and 210 minutes of the study (up to 9.2±0.4% 1.2 subgroup and up to 9.7±0.5% in patients 2.2 subgroup), as well as the total concentration of 13CO2 in at the end of 360 minutes of the study (up to 19.7±0.6% and up to 27.3±1.1%) according to the results of C13-mixed triglyceride breath tests, p<0,05. Conclusion. The use of a mini-tableted polyenzyme preparation with a minimum lipase activity of 25000 IU was a more effective method for correction of exocrine pancreatic insufficiency in patients with chronic pancreatitis and type 1 and 2 diabetes mellitus, than using a tableted polyenzyme preparation in a dose of 20000 IU per main meal. The study results showed that using C13-mixed triglyceride and C13-amylase breath test were highly informative methods for evaluating the effectiveness of enzyme replacement therapy in exocrine pancreatic insufficiency in patients with chronic pancreatitis and type 1 and 2 diabetes. The use of a mini-tablet polyenzyme drug in patients with chronic pancreatitis and type 1 and 2 diabetes mellitus is an effective means to normalize the manifestations of malabsorption in terms of α1-antitrypsin clearance

M1368 Prescription and Response to Pancreatic Enzyme Therapy in Exocrine Insufficiency Due to Chronic Pancreatitis; a Dutch National Survey

2010 ◽  
Vol 138 (5) ◽  
pp. S-390
Author(s):  
Edmée C. Sikkens ◽  
Djuna L. Cahen ◽  
Casper H. van Eijck ◽  
Ernst J. Kuipers ◽  
Marco J. Bruno
Keyword(s):  
Chronic Pancreatitis ◽  
National Survey ◽  
Pancreatic Enzyme ◽  
Enzyme Therapy ◽  
Exocrine Insufficiency

Symptomatic Effect of Pancreatic Enzyme Therapy in Patients with Chronic Pancreatitis

1986 ◽  
Vol 21 (1) ◽  
pp. 104-108 ◽  
Author(s):  
H. Halgreen ◽  
N. Thorsgaard Pedersen ◽  
H. Worning
Keyword(s):  
Chronic Pancreatitis ◽  
Pancreatic Enzyme ◽  
Enzyme Therapy ◽  
Symptomatic Effect

Reasons for the lack of effectiveness of substitution enzyme therapy in chronic pancreatitis (CP)

Pancreatology ◽  
2013 ◽  
Vol 13 (3) ◽  
pp. S70
Author(s):  
Natalya Gubergrits ◽  
Oksana Golubova
Keyword(s):  
Chronic Pancreatitis ◽  
Enzyme Therapy

Pancreatic Enzyme Therapy and Nutritional Status of Outpatients With Chronic Pancreatitis

2001 ◽  
Vol 24 (2) ◽  
pp. 84-87 ◽  
Author(s):  
Patricia A. Trolli ◽  
Darwin L. Conwell ◽  
Gregory Zuccaro
Keyword(s):  
Chronic Pancreatitis ◽  
Nutritional Status ◽  
Pancreatic Enzyme ◽  
Enzyme Therapy

scholarly journals Modern opportunities of pharmacotherapy of chronic pancreatitis

2017 ◽  
Vol 36 (2) ◽  
pp. 26-31
Author(s):  
Y. S. Tsimmerman
Keyword(s):  
Chronic Pancreatitis ◽  
Pain Relief ◽  
Clinical Picture ◽  
Enzyme Therapy ◽  
Surgical Interventions ◽  
Current Definition ◽  
Pancreatogenic Diabetes ◽  
Therapy Treatment

The lecture presents the current definition and classification of chronic pancreatitis, its prevalence, etiology and pathogenesis, clinical picture, diagnostics. Special attention is paid to the treatment, particularly medical one. Pain relief, principles of enzyme therapy, treatment of pancreatogenic diabetes are discussed in details. Indications for endoscopic and surgical interventions are noted.

scholarly journals The effectiveness of systemic enzyme therapy in complex treatment chronic pancreatitis in old age

2021 ◽  
Vol 11 (6) ◽  
pp. 209-216
Author(s):  
N. A. Shevchenko ◽  
L. S. Babinets
Keyword(s):  
Chronic Pancreatitis ◽  
Elderly Patients ◽  
Pancreatic Insufficiency ◽  
Colorimetric Method ◽  
Control Group ◽  
Enzyme Therapy ◽  
Complex Treatment ◽  
Functional Changes ◽  
Enzyme Replacement ◽  
Group I

Relevance. The variety of functional changes in internal organs characteristicofgeriatricage necessitates the search for drugs that can exert a multifaceted effect on various links in the pathogenesis of chronic pancreatitis (CP) in comorbidity with the most common diseases of the elderly. Purpose. Investigation of the effectiveness of the inclusion of a systemic enzyme therapy drug in the complex treatment of chronic pancreatitis in elderly patients. Materials and methods. We examined 77 patients with CP over the age of 66 years, the average age (71.3 ± 1.4) g. Group I of patients with CP (23 patients) - took aconventional therapeutic complex (MC) for three months: pantoprazole 40 mg on an empty stomach according to requirement, continuous enzyme replacement therapy with pure pancreatin in an adequate dose with each meal, prokinetics / or antispasmodics if necessary. Group II consisted of 34 patients with CP (MC + W), in addition to LK, the drug of systemic enzyme therapy (SET) Wobenzym, 5 tablets, was taken. three times a day for three months. The control group consisted of 20 patients without signs of pathology of the digestive system. The parameters of lipid metabolism were determined by the enzymatic-colorimetric method. The assessment of the depth of exocrine pancreatic insufficiency (PI) was determined by the level of fecal α-elastase (FαE) by enzyme-linked immunosorbentassay using standard BIOSERVELASTASE 1-ELISA kits. Statistical analysis was performed using Excel and the statistical package Statistica v. 5.0. Results. Additional inclusion of the drug SET (Wobenzym) in the generally accepted MC promoted a significant improvement in lipid profile parameters in elderly patients with CP, as well as a reliable correction of the excretory function of the P by the level of FαE (from the level of moderate to mild insufficiency). Conclusions. 1) The inclusion of Wobenzym in the general treatment complex contributed toa decrease in the levels of TC, βLP, TG and LDLP by 15.4%, 19.8%, 32.0% and 33.9%, respectively (p <0.001), as well as an increase in the level of HDLP by 21.7% and a decrease in AF (by 41.3%) (p <0.001); 2) under the influence of treatment with the use of Wobenzym, a significant increase in the level of FαE (by 42.6%) was found relative to this indicator to treatment (p <0.001), which significantly exceeded the results (by 15.8%) in the MC group, which were not statistically significant (p> 0.05).

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