scholarly journals Modern opportunities of pharmacotherapy of chronic pancreatitis

2017 ◽  
Vol 36 (2) ◽  
pp. 26-31
Author(s):  
Y. S. Tsimmerman
Keyword(s):  
Chronic Pancreatitis ◽  
Pain Relief ◽  
Clinical Picture ◽  
Enzyme Therapy ◽  
Surgical Interventions ◽  
Current Definition ◽  
Pancreatogenic Diabetes ◽  
Therapy Treatment

The lecture presents the current definition and classification of chronic pancreatitis, its prevalence, etiology and pathogenesis, clinical picture, diagnostics. Special attention is paid to the treatment, particularly medical one. Pain relief, principles of enzyme therapy, treatment of pancreatogenic diabetes are discussed in details. Indications for endoscopic and surgical interventions are noted.

Surgical treatment in patients with chronic pancreatitis in a multidisciplinary hospital

2021 ◽  
Vol 23 (3) ◽  
pp. 55-60
Author(s):  
Rustam K. Aliev ◽  
Pavel N. Romashchenko ◽  
Nicolay A. Maistrenko ◽  
Andrey S. Pryadko ◽  
Arsen K. Aliev
Keyword(s):  
Chronic Pancreatitis ◽  
Surgical Treatment ◽  
Morphological Changes ◽  
Specific Patient ◽  
Surgical Decision ◽  
Surgical Interventions

A rational personalized program of surgical treatment of patients with various clinical and morphological forms of chronic pancreatitis is substantiated, integrating modern diagnostic and minimally invasive technologies. Examination results and treatment of 354 patients with chronic pancreatitis were analyzed. Patients were divided into three groups according to the modified Marseille-Rome Classification of Chronic pancreatitis (1988). Calcifying chronic pancreatitis was detected in 119 patients, obstructive in 81, and inflammatory in 154. Modern methods of diagnosis and treatment of chronic pancreatitis allowed the modification of the classification by allocating subgroups for each disease form. The justified use of the entire range of modern surgical technologies, taking into account the morphological changes of the pancreas, allows the maximum correction of complications of chronic pancreatitis with minimal complications and good quality of life in the long-term. The choice of surgical aid in patients with chronic pancreatitis is established to primarily depend on the form and variant of the disease course. The main criteria for choosing a surgical aid should be the state of the pancreatic ductal system, the degree and nature of changes in its parenchyma, and the presence of a cystic or inflammatory component during the surgical decision making. Important adjustments in the stage of surgical interventions are made due to mechanical jaundice, portal hypertension, decompensated duodenal stenosis, and concomitant somatic pathology in patients. Subgroups of patients with identified main chronic pancreatitis form, according to its modified classification, allows the determination of the surgical intervention volume, type, and access for each specific patient.

Chronic pancreatitis in nurse practice

2020 ◽  
pp. 12-20
Author(s):  
Ellina Golieva ◽  
Vsevolod Skvortsov ◽  
Hedy Muradova ◽  
Georgy Malakkin
Keyword(s):  
Chronic Pancreatitis ◽  
Complex Treatment ◽  
Clinical Symptomatology ◽  
Diagnostic Standards

This article deals with problems of pathogenesis, clinical symptomatology, approaches to this review represents the data on classification of chronic pancreatitis; discusses symptoms of this disease; studies diagnostic standards at inspection of patients with chronic pancreatitis; acquaints with principles of complex treatment of this pathology.

scholarly journals Automatic Evaluation of the Lung Condition of COVID-19 Patients Using X-ray Images and Convolutional Neural Networks

2021 ◽  
Vol 11 (1) ◽  
pp. 28
Author(s):  
Ivan Lorencin ◽  
Sandi Baressi Šegota ◽  
Nikola Anđelić ◽  
Anđela Blagojević ◽  
Tijana Šušteršić ◽  
...  
Keyword(s):  
Neural Networks ◽  
Convolutional Neural Networks ◽  
Clinical Picture ◽  
Data Augmentation ◽  
Lower Amount ◽  
Training Procedure ◽  
X Ray ◽  
Severe Clinical Picture ◽  
Lung Condition

COVID-19 represents one of the greatest challenges in modern history. Its impact is most noticeable in the health care system, mostly due to the accelerated and increased influx of patients with a more severe clinical picture. These facts are increasing the pressure on health systems. For this reason, the aim is to automate the process of diagnosis and treatment. The research presented in this article conducted an examination of the possibility of classifying the clinical picture of a patient using X-ray images and convolutional neural networks. The research was conducted on the dataset of 185 images that consists of four classes. Due to a lower amount of images, a data augmentation procedure was performed. In order to define the CNN architecture with highest classification performances, multiple CNNs were designed. Results show that the best classification performances can be achieved if ResNet152 is used. This CNN has achieved AUCmacro¯ and AUCmicro¯ up to 0.94, suggesting the possibility of applying CNN to the classification of the clinical picture of COVID-19 patients using an X-ray image of the lungs. When higher layers are frozen during the training procedure, higher AUCmacro¯ and AUCmicro¯ values are achieved. If ResNet152 is utilized, AUCmacro¯ and AUCmicro¯ values up to 0.96 are achieved if all layers except the last 12 are frozen during the training procedure.

scholarly journals Endoscopic versus Surgical Intervention for Painful Obstructive Chronic Pancreatitis: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 10 (12) ◽  
pp. 2636
Author(s):  
Ka Wing Ma ◽  
Hoonsub So ◽  
Euisoo Shin ◽  
Janice Hoi Man Mok ◽  
Kim Ho Kam Yuen ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Pain Relief ◽  
Meta Analysis ◽  
Small Sample ◽  
Cochrane Library ◽  
Endoscopic Drainage ◽  
Complication Rates ◽  
Surgical Drainage ◽  
Endocrine Insufficiency ◽  
Significant Difference

There is limited evidence on the standard care for painful obstructive chronic pancreatitis (CP), while comparisons of endoscopic and surgical modes for pain relief have yielded conflicting results from small sample sizes. We aimed to obtain a clear picture of the matter by a meta-analysis of these results. We searched the Pubmed, Embase, and Cochrane Library databases to identify studies comparing endoscopic and surgical treatments for painful obstructive CP. Pooled effects were calculated by the random effect model. Primary outcomes were overall pain relief (complete and partial), and secondary outcomes were complete and partial pain relief, complication rate, hospitalization duration, and endocrine insufficiency. Seven studies with 570 patients were included in the final analysis. Surgical drainage was associated with superior overall pain relief [OR 0.33, 95% CI 0.23–0.47, p < 0.001, I2 = 4%] and lesser incidence of endocrine insufficiency [OR 2.10, 95% CI 1.20–3.67, p = 0.01, I2 = 0%], but no significant difference in the subgroup of complete [OR 0.57, 95% CI 0.32–1.01, p = 0.054, I2 = 0%] or partial [OR 0.67, 95% CI 0.37–1.22, p = 0.19, I2 = 0%] pain relief, complication rates [OR 1.00, 95% CI 0.41–2.46, p = 0.99, I2 = 49%], and hospital stay [OR −0.54, 95% CI −1.23–0.15, p = 0.13, I2 = 87%] was found. Surgery is associated with significantly better overall pain relief and lesser endocrine insufficiency in patients with painful obstructive CP. However, considering the invasiveness of surgery, no significant differences in complete or partial pain relief, and heterogeneity of a few parameters between two groups, endoscopic drainage may be firstly performed and surgical drainage may be considered when endoscopic drainage fails.

Muscular syndrome in patients with inflammatory and degenerative diseases of joints and vertebral column

1999 ◽  
Vol 80 (2) ◽  
pp. 113-116
Author(s):  
R. A. Khabirov
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatic Diseases ◽  
Clinical Picture ◽  
Skeletal Muscles ◽  
Vertebral Column ◽  
Degenerative Diseases ◽  
Muscular System ◽  
Pathogenetic Mechanisms ◽  
Diagnosis Criteria

The manifestations of muscular syndrome affecting the gravity and prediction of the disease take place in the most widespread and invalidizing rheumatic diseases: osteoarthrosis, rheumatoid arthritis and ankylosing spondylarthritis. Paraclinical studies showed heterogeneity of pathogenetic mechanisms in lesion of skeletal muscles in rheumatic diseases. The differentiated methods of the treatment of patients with osteoarthrosis, rheumatoid arthritis and ankylosing spondylarthritis taking into account the clinical picture and pathogenesis of muscular syndrome, as well as the diagnosis criteria and classification of muscular system lesion are suggested.

scholarly journals OPTIMIZATION OF DIAGNOSIS AND TREATMENT FOR PERIPROSTHETIC KNEE INFECTION

2017 ◽  
pp. 14-19
Author(s):  
S. P. Shpinyak ◽  
A. P. Barabash ◽  
Yu. A. Barabash
Keyword(s):  
Public Health ◽  
Periprosthetic Infection ◽  
Public Health System ◽  
Diagnosis And Treatment ◽  
Surgical Interventions ◽  
Knee Infection ◽  
Long Period ◽  
Periprosthetic Knee Infection

Purpose of study: to analyze the modern approaches to classification of large joints periprosthetic infection (PPI) and evaluate the results of revision surgical interventions in patients with deep PPI of the knee. Patients and methods. One hundred fifty three patients, 51 men and 102 women (mean age 57.3±12.4 years), with deep PPI were operated on. Treatment tactics was determined by the term after primary operation. In early PPI (n=31) sanitation interventions with implant preservation and in late PPI (n=122) – two step interventions with long period between the operations (over 4 weeks) were performed. Results. Follow up made up from 2 to 5 years. Sanitation interventions with implant preservation were successful in71% of patients. In group of patients with late PPI satisfactory results were achieved in 89.6% of cases. On the basis of the obtained data the variants of diagnosis and treatment tactics optimization as well as its adaptation to domestic public health system were proposed.

scholarly journals ХИРУРГИЯ ЭКССУДАТИВНЫХ ПЕРИКАРДИТОВ

2019 ◽  
pp. 14-19
Author(s):  
Лигоненко А. В.
Keyword(s):  
Pericardial Effusion ◽  
Diagnostic Methods ◽  
Common Disease ◽  
Clinical Progression ◽  
Surgical Interventions ◽  
Pericardial Cavity ◽  
Differential Approach ◽  
Literary Sources ◽  
Choice Of Treatment

In the article are presented modern approaches to diagnostics, etiological search and methods of surgical correction of pericardial effusion (PE) of different etiology. PE being the most common disease of the pericardium, often has a secondary nature. The overview of modern literature data is presented about terminology and classification of PE, the possibility of etiological search for the cause of effusion in the pericardial cavity, the main diagnostic methods, as well as the main tasks and methods of pericardial surgical interventions and its indications. Based on the analysis of literary sources, we can conclude that the consensus on the clinical and nosological structure, effectiveness and necessity of using various tests and interventions, clinical progression, epidemiology, prognosis and the reasons for the unsatisfactory results of treated PE is actually absent. Our analysis indicates the absence of a systematic and differential approach to choice of treatment tactics.

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