Regulation of Secretion in Human Basophils

Author(s):  
Donald MacGlashan
2000 ◽  
pp. 195-207 ◽  
Author(s):  
Macglashan JR Donald ◽  
Sandra Lavens-Phillips ◽  
Katsushi Miura

Author(s):  
William J. Dougherty

The regulation of secretion in exocrine and endocrine cells has long been of interest. Electron microscopic and other studies have demonstrated that secretory proteins synthesized on ribosomes are transported by the rough ER to the Golgi complex where they are concentrated into secretory granules. During active secretion, secretory granules fuse with the cell membrane, liberating and discharging their contents into the perivascular spaces. When secretory activity is suppressed in anterior pituitary cells, undischarged secretory granules may be degraded by lysosomes. In the parathyroid gland, evidence indicates that the level of blood Ca ions regulates both the production and release of parathormone. Thus, when serum Ca is low, synthesis and release of parathormone are both stimulated; when serum Ca is elevated, these processes are inhibited.


FEBS Letters ◽  
1987 ◽  
Vol 213 (1) ◽  
pp. 195-198 ◽  
Author(s):  
Peter Nygren ◽  
Rolf Larsson ◽  
Erik Lindh ◽  
Sverker Ljunghal ◽  
Jonas Rastad ◽  
...  

2007 ◽  
Vol 37 (12) ◽  
pp. 1854-1862 ◽  
Author(s):  
J. Lin ◽  
N. Renault ◽  
H. Haas ◽  
G. Schramm ◽  
S. Vieths ◽  
...  

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