Faculty Opinions recommendation of Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33.

In the past 10 years or so, many alternatives to warfarin have been developed the first being the novel oral anticoagulants (NOAC) or better referred to as direct oral anticoagulants (DOAC) or target-specific oral anticoagulants (TSOAC). These drugs have some definite advantages and disadvantages that should be clear to physicians before prescribing any of them for patients. Many clinical trials have provided definitive information about the efficacy and safety of DOACs, yet many physicians remain sceptical about prescribing these drugs due to lack of answers to real world questions. The concerns are directed towards appropriate patient selection (the choice should be made according to age, renal function, compliance, cost, clinical condition, intake of other drugs), the mechanism of switching between agents, how these drugs affect routine laboratory tests and when monitoring is needed. Knowledge of other drugs that interact with the DOAC and management of severe bleeding will be reviewed and recommendations will be given to all of these concerns.

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Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes

Oncogene ◽

10.1038/sj.onc.1208695 ◽

2005 ◽

Vol 24 (32) ◽

pp. 5131-5136 ◽

Cited By ~ 28

Author(s):

Yasushi Sasaki ◽

Yasuyoshi Naishiro ◽

Yuichiro Oshima ◽

Kohzoh Imai ◽

Yusuke Nakamura ◽

...

Keyword(s):

Family Member ◽

Pigment Epithelium ◽

P53 Family ◽

Pigment Epithelium Derived Factor ◽

Direct Target

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Histamine and Sulfidoleukotriene Release from Human Basophils: Different Effects of Antigen, Anti-IgE, C5a, f-Met-Leu-Phe and the Novel Neutrophil-Activating Peptide NAF

International Archives of Allergy and Immunology ◽

10.1159/000235011 ◽

1989 ◽

Vol 90 (2) ◽

pp. 113-118 ◽

Cited By ~ 20

Author(s):

Clemens A. Dahinden ◽

Joshiyuki Kurimoto ◽

Marco Baggiolini ◽

Beatrice Dewald ◽

Alfred Walz

Keyword(s):

The Novel ◽

Human Basophils

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The Novel SPARC Family Member SMOC-2 Potentiates Angiogenic Growth Factor Activity

Journal of Biological Chemistry ◽

10.1074/jbc.m513463200 ◽

2006 ◽

Vol 281 (32) ◽

pp. 22855-22864 ◽

Cited By ~ 69

Author(s):

Edward F. Rocnik ◽

Peijun Liu ◽

Kaori Sato ◽

Kenneth Walsh ◽

Cyrus Vaziri

Keyword(s):

Growth Factor ◽

Family Member ◽

The Novel ◽

Factor Activity ◽

Angiogenic Growth Factor

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Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in Endometrial Carcinoma

Technology in Cancer Research & Treatment ◽

10.1177/1533033820983079 ◽

2020 ◽

Vol 19 ◽

pp. 153303382098307

Author(s):

Bo Wu ◽

Ailing Ren ◽

Ying Tian ◽

Ruizhen Huang

Keyword(s):

Cell Proliferation ◽

Endometrial Carcinoma ◽

Cell Apoptosis ◽

Biological Function ◽

The Novel ◽

The World ◽

Negative Effect ◽

Ec Cells ◽

Direct Target

Although the cases of endometrial carcinoma (EC) is gradually increasing across the world, its etiology and pathogenesis remain unknown. The present study is the first to define the role and biological function of circRNA hsa_circ_0075960 in the development and progression of EC. We first determined that hsa_circ_0075960 is aberrantly expressed in EC cells. Then, we uncovered that the downregulation of hsa_circ_0075960 suppressed cell proliferation and promoted cell apoptosis of EC cells, suggesting that hsa_circ_0075960 could inhibit the progression of EC in vitro. In addition, we identified that miR-361-3p was the direct target of hsa_circ_0075960. Further analysis revealed that hsa_circ_0075960 affected the development of EC via sponging miR-361-3p. Interestingly, we verified that the level of SH2B1 was controlled by the downregulation of hsa_circ_0075960 and that the negative effect caused by hsa_circ_0075960 could be reversed via miR-361-3p inhibition. Our cumulative results revealed that the novel tumor regulator hsa_circ_0075960 functioned as a sponge for miR-361-3p/SH2B1 in EC cells and regulated the progression of EC through the modulation of miR-361-3p.

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CDK13-Mediated Cell Cycle Disorder Promotes Tumorigenesis of High HMGA2 Expression Gastric Cancer

Frontiers in Molecular Biosciences ◽

10.3389/fmolb.2021.707295 ◽

2021 ◽

Vol 8 ◽

Author(s):

Zhouying Wu ◽

Min Wang ◽

Feng Li ◽

Feng Wang ◽

Jianchao Jia ◽

...

Keyword(s):

Gastric Cancer ◽

Cell Cycle ◽

Target Gene ◽

Single Gene ◽

The Novel ◽

Positive Relation ◽

Adjacent Tissue ◽

M Phase ◽

Direct Target Gene ◽

Direct Target

The inhibitor of CDK4/6 has been clinically used for treating certain types of cancer which are characterized by G0/G1 acceleration induced by the CDK4/6-RB1 pathway. On the contrary, the cell cycle–related molecules are abnormal in over 50% of the patients with gastric cancer (GC), but the efficiency of inhibiting CDK4/6 does not work well as it is expected. In our study, we found HMGA2 promotes GC through accelerating the S–G2/M phase transition, instead of G0/G1. We also found CDK13 is the direct target gene of HMGA2. Importantly, we analyzed 200 pairs of GC and the adjacent tissue and proved the positive relation between HMGA2 and CDK13; moreover, high expression of both genes predicts a poorer prognosis than the expression of single gene does. We explored the effect of the novel CDK12/13 inhibiting agent, SR-4835, on high HMGA2 expression GC and found inhibition of both genes jointly could reach a satisfied result. Therefore, we suggest that inhibition of CDK13 and HMGA2 simultaneously could be an effective strategy for high HMGA2 expression GC. To detect the expression of both genes simultaneously and individually could be of benefit to predict prognosis for GC.

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