Cytokine-Deficient Mouse Mutants

1996 ◽  
pp. 167-169
Author(s):  
Werner Müller
Keyword(s):  
Deficient Mouse ◽  
Mouse Mutants

Somatic hypermutation occurs in B cells of terminal deoxynucleotidyl transferase-, CD23-, interleukin-4-, IgD- and CD30-deficient mouse mutants

1996 ◽  
Vol 26 (8) ◽  
pp. 1966-1969 ◽  
Author(s):  
Gemma Texidó ◽  
Heinz Jacobs ◽  
Myriam Meiering ◽  
Ralf Kühn ◽  
Jürgen Roes ◽  
...  
Keyword(s):  
B Cells ◽  
Somatic Hypermutation ◽  
Interleukin 4 ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Deficient Mouse ◽  
Mouse Mutants

Nerve growth factor in three neurologically deficient mouse mutants

1984 ◽  
Vol 50 (1-3) ◽  
pp. 121-126 ◽  
Author(s):  
Ted Ebendal ◽  
Lars-G. Lundin
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Deficient Mouse ◽  
Nerve Growth ◽  
Mouse Mutants

Abscess formation inListeria monocytogenes-infectedγδT cell deficient mouse mutants involvesαβT cells

1997 ◽  
Vol 22 (2) ◽  
pp. 123-128 ◽  
Author(s):  
Sybille Thoma-Uszynski ◽  
Christoph H. Ladel ◽  
Stefan H.E. Kaufmann
Keyword(s):  
Abscess Formation ◽  
Deficient Mouse ◽  
Mouse Mutants

Conditional gp130 deficient mouse mutants

2008 ◽  
Vol 19 (4) ◽  
pp. 379-384 ◽  
Author(s):  
Nicolas Fasnacht ◽  
Werner Müller
Keyword(s):  
Deficient Mouse ◽  
Mouse Mutants

scholarly journals Deficiency of the onco-miRNA cluster, miR-106b∼25, causes oligozoospermia and the cooperative action of miR-106b∼25 and miR-17∼92 is required to maintain male fertility

2020 ◽  
Vol 26 (6) ◽  
pp. 389-401
Author(s):  
Alicia Hurtado ◽  
Rogelio Palomino ◽  
Ina Georg ◽  
Miguel Lao ◽  
Francisca M Real ◽  
...  
Keyword(s):  
Male Fertility ◽  
Molecular Mechanisms ◽  
Mirna Cluster ◽  
Knock Out ◽  
Cooperative Action ◽  
Mouse Mutants ◽  
New Genes ◽  
Mirna Clusters ◽  
Testicular Histology ◽  
And Function

Abstract The identification of new genes involved in sexual development and gonadal function as potential candidates causing male infertility is important for both diagnostic and therapeutic purposes. Deficiency of the onco-miRNA cluster miR-17∼92 has been shown to disrupt spermatogenesis, whereas mutations in its paralog cluster, miR-106b∼25, that is expressed in the same cells, were reported to have no effect on testis development and function. The aim of this work is to determine the role of these two miRNA clusters in spermatogenesis and male fertility. For this, we analyzed miR-106b∼25 and miR-17∼92 single and double mouse mutants and compared them to control mice. We found that miR-106b∼25 knock out testes show reduced size, oligozoospermia and altered spermatogenesis. Transcriptomic analysis showed that multiple molecular pathways are deregulated in these mutant testes. Nevertheless, mutant males conserved normal fertility even when early spermatogenesis and other functions were disrupted. In contrast, miR-17∼92+/−; miR-106b∼25−/− double mutants showed severely disrupted testicular histology and significantly reduced fertility. Our results indicate that miR-106b∼25 and miR-17∼92 ensure accurate gene expression levels in the adult testis, keeping them within the required thresholds. They play a crucial role in testis homeostasis and are required to maintain male fertility. Hence, we have identified new candidate genetic factors to be screened in the molecular diagnosis of human males with reproductive disorders. Finally, considering the well-known oncogenic nature of these two clusters and the fact that patients with reduced fertility are more prone to testicular cancer, our results might also help to elucidate the molecular mechanisms linking both pathologies.

scholarly journals Stromally Derived Lysyl Oxidase Promotes Metastasis of Transforming Growth Factor-β–Deficient Mouse Mammary Carcinomas

2013 ◽  
Vol 73 (17) ◽  
pp. 5336-5346 ◽  
Author(s):  
Michael W. Pickup ◽  
Hanane Laklai ◽  
Irene Acerbi ◽  
Philip Owens ◽  
Agnieszka E. Gorska ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor ◽  
Lysyl Oxidase ◽  
Transforming Growth Factor Β ◽  
Deficient Mouse ◽  
Mammary Carcinomas
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