Lipid—Protein Interactions in the Function of the Na+ and H+ Pumps Role of Sulfatide

1988 ◽  
pp. 211-232
Author(s):  
F. Zambrano ◽  
M. Rojas
Keyword(s):  
Protein Interactions ◽  
Lipid Protein Interactions

Divalent cation and lipid-protein interactions of biomembranes

1993 ◽  
Vol 13 (3) ◽  
pp. 143-157 ◽  
Author(s):  
F. Y. Yang ◽  
Y. G. Huang ◽  
Y. P. Tu
Keyword(s):  
Adenylate Cyclase ◽  
Atpase Activity ◽  
Enzymatic Activity ◽  
Divalent Cation ◽  
Protein Interactions ◽  
Physical State ◽  
Divalent Cations ◽  
Activity Change ◽  
Lipid Protein Interactions

Divalent cations play an important role in the functions of biomembranes. This review deals with three topics: (1) Mg2+-mediated change in physical state of phospholipid induces conformation and activity change of reconstituted mitochondrial H+-ATPase, (2) a proper transmembrane Ca2+ gradient is essential for the higher enzymatic activity of adenylate cyclase, and (3) role of transmembrane Ca2+ gradient in the modulation of reconstituted sarcoplasmic reticulm Ca2+-ATPase activity.

scholarly journals Assessing the Role of Lipids in the Molecular Mechanism of Membrane Proteins

2021 ◽  
Vol 22 (14) ◽  
pp. 7267
Author(s):  
Léni Jodaitis ◽  
Thomas van Oene ◽  
Chloé Martens
Keyword(s):  
Membrane Proteins ◽  
Molecular Mechanism ◽  
Protein Interactions ◽  
Protein Function ◽  
Biological Membrane ◽  
Allosteric Coupling ◽  
Lipid Protein Interactions ◽  
Experimental Challenge ◽  
Membrane Protein Function

Membrane proteins have evolved to work optimally within the complex environment of the biological membrane. Consequently, interactions with surrounding lipids are part of their molecular mechanism. Yet, the identification of lipid–protein interactions and the assessment of their molecular role is an experimental challenge. Recently, biophysical approaches have emerged that are compatible with the study of membrane proteins in an environment closer to the biological membrane. These novel approaches revealed specific mechanisms of regulation of membrane protein function. Lipids have been shown to play a role in oligomerization, conformational transitions or allosteric coupling. In this review, we summarize the recent biophysical approaches, or combination thereof, that allow to decipher the role of lipid–protein interactions in the mechanism of membrane proteins.

scholarly journals Lipid Microdomains in Cell Nucleus

2008 ◽  
Vol 19 (12) ◽  
pp. 5289-5295 ◽  
Author(s):  
Giacomo Cascianelli ◽  
Maristella Villani ◽  
Marcello Tosti ◽  
Francesca Marini ◽  
Elisa Bartoccini ◽  
...  
Keyword(s):  
Protein Interactions ◽  
Lipid Composition ◽  
Protein Complexes ◽  
Membrane Microdomains ◽  
Cellular Functions ◽  
Transcription Process ◽  
Lipid Protein Interactions ◽  
First Time ◽  
Specific Lipid

It is known that nuclear lipids play a role in proliferation, differentiation, and apoptotic process. Cellular nuclei contain high levels of phosphatidylcholine and sphingomyelin, which are partially linked with cholesterol and proteins to form lipid–protein complexes. These lipids are also associated with transcription factors and newly synthesized RNA but, up to date, their organization is still unknown. The aim of the present work was to study if these specific lipid–protein interactions could be nuclear membrane microdomains and to evaluate their possible role. The results obtained demonstrate for the first time the existence of nuclear microdomains characterized by a specific lipid composition similar to that of intranuclear lipid–protein complexes previously described. Nuclear microdomain lipid composition changes during cell proliferation when the content of newly synthesized RNA increases. Because previous data show a correlation between nuclear lipids and transcription process, the role of nuclear microdomains in cellular functions is discussed.

Sign in / Sign up

Export Citation Format

Share Document