Regulation of Beta-Adrenergic Pathways in the Heart

1987 ◽  
pp. 205-216 ◽  
Author(s):  
C. J. Limas ◽  
C. Limas
Keyword(s):  
Beta Adrenergic

Beta adrenergic blockade and circulating eosinophils

1968 ◽  
Vol 121 (3) ◽  
pp. 255-258 ◽  
Author(s):  
J. Koch-Weser
Keyword(s):  
Adrenergic Blockade ◽  
Beta Adrenergic

CATECHOLAMINE ANTAGONISM TO OXYTOCIN-INDUCED MILK-EJECTION

1971 ◽  
Vol 68 (1_Suppla) ◽  
pp. S5-S38 ◽  
Author(s):  
Helmuth Vorherr
Keyword(s):  
Receptor Blockade ◽  
Milk Ejection ◽  
Beta Adrenergic ◽  
Beta Receptor ◽  
Beta Receptors ◽  
Alpha Receptors ◽  
Adrenergic Blockers ◽  
Beta Receptor Blockade ◽  
Second Pain ◽  
Stimulation Of

ABSTRACT In lactating rats and rabbits the mode of antagonism of sympathomimetics, angiotensin or pain toward oxytocin-induced milk-ejection was investigated. In rats intra-arterial (intrafemoral) doses of 0.01–0.02 μg or intravenous (iv) doses of 0.1–0.5 μg of either epinephrine, isoproterenol, norepinephrine, angiotensin or 10 μg of phenylephrine injected simultaneously with, or 30 seconds before an oxytocin dose (10 μU intrafemoral, 300 μU iv) greatly inhibited or suppressed the oxytocin response. A 15 second pain stimulus caused moderate inhibition. With alpha-receptor blockade pain, epinephrine, isoproterenol, norepinephrine, phenylephrine and angiotensin inhibition were, respectively, 70%, 75%, 100%, 40%, 0% and 100%. Under beta-receptor blockade the corresponding values were 14%, 40%, 0%, 70%, 100% and 100%; with simultaneous intrafemoral injections neither catecholamine was inhibitory toward oxytocin. In corresponding rabbit experiments approximately 10-fold higher iv drug dosages were applied and similar results were observed. In both species, combined alpha and beta-receptor blockade nearly eliminated the antagonistic actions of sympathomimetics toward oxytocin, whereas angiotensin inhibition persisted unchanged. The results indicate: 1) Mammary myoepithelial cells contain beta-adrenergic receptors but no alpha-receptors; 2) Inhibition of oxytocin-induced milk-ejection by isoproterenol and phenylephrine is meditated through stimulation of myoepithelial beta-receptors (myoepithelial relaxation) and vascular alpha-receptors (vasoconstriction), respectively; 3) Epinephrine and norepinephrine inhibition of milk-ejection is due to stimulation of vascular alpha-receptors and myoepithelial beta-receptors; 4) Angiotensin effects are unrelated to adrenergic receptor mechanisms; 5) Administration of both alpha and beta-adrenergic blockers is desirable for stabilizing the sensitivity of the oxytocin milk-ejection assay preparation against interference from endogenous or exogenous catecholamines; 6) Other than using adrenergic blockers, pharmacologic doses of oxytocin can correct nursing difficulties in animals and man with hyperfunction of the adrenal-sympathetic system.

Are beta -Adrenergic Bronchodilators Safe?

PEDIATRICS ◽  
1997 ◽  
Vol 99 (5) ◽  
pp. 729-729 ◽  
Author(s):  
P. A. Eggleston
Keyword(s):  
Beta Adrenergic

Challenging the Adipocyte Color Barrier—TR Activation Elicits White to Beige Transdifferentiation Independent of Beta-Adrenergic Signaling

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2039-P
Author(s):  
YAN XIA ◽  
XIAOFEI LIANG ◽  
MARK E. LEE ◽  
KEVIN PHILLIPS
Keyword(s):  
Beta Adrenergic ◽  
Adrenergic Signaling

Epinephrine enhancement of potassium-stimulated immunoreactive insulin secretion. Role of beta-adrenergic receptors

Diabetes ◽  
1978 ◽  
Vol 27 (5) ◽  
pp. 550-553 ◽  
Author(s):  
N. Hiatt ◽  
M. B. Davidson ◽  
L. W. Chapman ◽  
J. A. Sheinkopf
Keyword(s):  
Insulin Secretion ◽  
Adrenergic Receptors ◽  
Immunoreactive Insulin ◽  
Beta Adrenergic Receptors ◽  
Beta Adrenergic
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