Cytomegalovirus Infection and the Immune System

1986 ◽  
pp. 59-66
Author(s):  
Mary Ann South ◽  
David A. Fuccillo ◽  
John L. Sever
Keyword(s):  
Immune System ◽  
Cytomegalovirus Infection

scholarly journals Impact of cytomegalovirus-infection on ageing of the immune system

10.33540/66 ◽  
2020 ◽  
Author(s):  
◽  
Sara Petra Hendrika van den Berg van den Berg
Keyword(s):  
Immune System ◽  
Cytomegalovirus Infection

scholarly journals Hemophagocytic Lymphohistiocytosis in a Patient With Advanced HIV and Cytomegalovirus Infection

2020 ◽  
Vol 8 ◽  
pp. 232470962090696
Author(s):  
Amir Anabtawi ◽  
Reem Alkilany ◽  
Mary E. Lacy
Keyword(s):  
Immune System ◽  
Early Detection ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Cytomegalovirus Infection ◽  
Autoimmune Disorders ◽  
Special Populations ◽  
Immune System Activation ◽  
System Activation

Hemophagocytic lymphohistiocytosis (HLH) is a rare, aggressive, and, if not treated, fatal disorder that is characterized by excessive immune system activation. This disorder can be precipitated by different triggers including malignancies, infections, and autoimmune disorders. Diagnosis is made by fulfilling criteria that was last updated in 2004, and treatment frequently includes management of the underlying trigger but can also include chemotherapy. In this article, we report a case of HLH in a 27-year-old male, who had been diagnosed with advanced untreated HIV, who presented to the hospital with fever and generalized fatigue with no obvious etiology. Infectious workup revealed cytomegalovirus viremia, and the patient met HLH criteria with impressive hyperferritinemia of 15 432 ng/mL. The patient was started on treatment for cytomegalovirus infection that led to resolution of HLH. Our report highlights the importance of early detection of HLH in special populations, and that treating the presumptive trigger can lead to resolution of HLH.

MONOCLONAL MACROGLOBULINEMIA AND CYTOMEGALIC INCLUSION DISEASE

PEDIATRICS ◽  
1973 ◽  
Vol 51 (3) ◽  
pp. 518-524
Author(s):  
Arthur G. Weinberg ◽  
George H. McCracken ◽  
Joseph LoSpalluto ◽  
James P. Luby
Keyword(s):  
Immune System ◽  
Cytomegalovirus Infection ◽  
Pneumocystis Carinii ◽  
Postmortem Examination ◽  
Light Chains ◽  
Antibody Activity ◽  
Documented Case ◽  
Cytomegalic Inclusion Disease ◽  
Kappa Light Chains

An 8-month-old infant with cytomegalovirus infection and monoclonal macroglobulinemia is described. The abnormal IgM reached levels of 2,700 to 3,200 mg/100 ml in serum, had no demonstrable antibody activity and contained kappa light chains only. Cytomegalovirus was recovered from throat and urine throughout life and the infant had histopathologic evidence of disseminated cytomegalovirus and pulmonary Pneumocystis carinii infections at postmortem examination. The presence of an underlying defect of the immune system could not be established with certainty. To our knowledge, this is the first documented case of cytomegalovirus infection and monoclonal macroglobulinemia.

▾Ganciclovir for cytomegalovirus infection

1989 ◽  
Vol 27 (20) ◽  
pp. 79-80
Keyword(s):  
Immune System ◽  
Nucleoside Analogue ◽  
Cytomegalovirus Infection ◽  
Herpes Virus ◽  
Virus Infections ◽  
Cmv Infection ◽  
Herpes Virus Infections ◽  
Herpès Virus

Cytomegalovirus (CMV) infection is usually trivial, but in patients whose immune system is suppressed, e.g. by AIDS, it can cause lethal lung and gut infections and blindness from retinitis. Ganciclovir (Cymevene - licensed to Syntex; discovered by Wellcome) is the first drug with useful activity against CMV. In vitro it is ten times as active against CMV as acyclovir, a related nucleoside analogue used in other herpes virus infections.1

scholarly journals Impact of Persistent Cytomegalovirus Infection on Dynamic Changes in Human Immune System Profile

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0151965 ◽  
Author(s):  
Rosanna Vescovini ◽  
Anna Rita Telera ◽  
Mario Pedrazzoni ◽  
Barbara Abbate ◽  
Pietro Rossetti ◽  
...  
Keyword(s):  
Immune System ◽  
Cytomegalovirus Infection ◽  
Human Immune System ◽  
Dynamic Changes ◽  
Human Immune
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