Noninvasive Monitoring of the In Vivo Release Characteristics of Rectal Drug Delivery Devices

1984 ◽  
pp. 321-341
Author(s):  
Arthur R. Mlodozeniec ◽  
Larry Caldwell ◽  
Michael Jay ◽  
Robert M. Beihn ◽  
George A. Digenis
Keyword(s):  
Drug Delivery ◽  
Noninvasive Monitoring ◽  
In Vivo Release ◽  
Rectal Drug Delivery ◽  
Drug Delivery Devices

Recent In Vitro and In Silico Advances in the Understanding of Intranasal Drug Delivery

2020 ◽  
Vol 26 ◽  
Author(s):  
John Chen ◽  
Andrew Martin ◽  
Warren H. Finlay
Keyword(s):  
Drug Delivery ◽  
In Silico ◽  
Local Drug Delivery ◽  
In Vivo Studies ◽  
Intranasal Drug Delivery ◽  
Nasal Sprays ◽  
In Silico Studies ◽  
Drug Delivery Devices

Background: Many drugs are delivered intranasally for local or systemic effect, typically in the form of droplets or aerosols. Because of the high cost of in vivo studies, drug developers and researchers often turn to in vitro or in silico testing when first evaluating the behavior and properties of intranasal drug delivery devices and formulations. Recent advances in manufacturing and computer technologies have allowed for increasingly realistic and sophisticated in vitro and in silico reconstructions of the human nasal airways. Objective: To perform a summary of advances in understanding of intranasal drug delivery based on recent in vitro and in silico studies. Conclusion: The turbinates are a common target for local drug delivery applications, and while nasal sprays are able to reach this region, there is currently no broad consensus across the in vitro and in silico literature concerning optimal parameters for device design, formulation properties and patient technique which would maximize turbinate deposition. Nebulizers are able to more easily target the turbinates, but come with the disadvantage of significant lung deposition. Targeting of the olfactory region of the nasal cavity has been explored for potential treatment of central nervous system conditions. Conventional intranasal devices, such as nasal sprays and nebulizers, deliver very little dose to the olfactory region. Recent progress in our understanding of intranasal delivery will be useful in the development of the next generation of intranasal drug delivery devices.

Drug Delivery Devices and Targeting Agents for Platinum(II) Anticancer Complexes

2008 ◽  
Vol 61 (9) ◽  
pp. 675 ◽  
Author(s):  
Anwen M. Krause-Heuer ◽  
Maxine P. Grant ◽  
Nikita Orkey ◽  
Janice R. Aldrich-Wright
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Anticancer Agents ◽  
Drug Transport ◽  
Water Solubility ◽  
Controlled Drug Release ◽  
Drug Bioavailability ◽  
Platinum Drug ◽  
Drug Delivery Devices

An ideal platinum-based delivery device would be one that selectively targets cancerous cells, can be systemically delivered, and is non-toxic to normal cells. It would be beneficial to provide drug delivery devices for platinum-based anticancer agents that exhibit high drug transport capacity, good water solubility, stability during storage, reduced toxicity, and enhanced anticancer activity in vivo. However, the challenges for developing drug delivery devices include carrier stability in vivo, the method by which extracellular or intracellular drug release is achieved, overcoming the various mechanisms of cell resistance to drugs, controlled drug release to cancer cells, and platinum drug bioavailability. There are many potential candidates under investigation including cucurbit[n]urils, cyclodextrins, calix[n]arenes, and dendrimers, with the most promising being those that are synthetically adaptable enough to attach to targeting agents.

In vivo release from a drug delivery MEMS device

2004 ◽  
Vol 100 (2) ◽  
pp. 211-219 ◽  
Author(s):  
Yawen Li ◽  
Rebecca S. Shawgo ◽  
Betty Tyler ◽  
Paul T. Henderson ◽  
John S. Vogel ◽  
...  
Keyword(s):  
Drug Delivery ◽  
In Vivo Release ◽  
Mems Device

In Vitro and In Vivo Release Characteristics of Tacrolimus (FK506) from an Episcleral Drug-Delivery Implant

2014 ◽  
Vol 30 (8) ◽  
pp. 670-680 ◽  
Author(s):  
Shuyi Mai ◽  
Leilei Lin ◽  
Wei Yang ◽  
Xuejiao Deng ◽  
Zhiyong Xie ◽  
...  
Keyword(s):  
Drug Delivery ◽  
In Vivo Release

Methylprednisolone esters of hyaluronic acid in ophthalmic drug delivery: in vitro and in vivo release studies

1992 ◽  
Vol 80 (1-3) ◽  
pp. 161-169 ◽  
Author(s):  
Kristiina Kyyrönen ◽  
Lisbeth Hume ◽  
Luca Benedetti ◽  
Arto Urtti ◽  
Elizabeth Topp ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Ophthalmic Drug Delivery ◽  
In Vivo Release ◽  
Release Studies ◽  
Ophthalmic Drug

Study of Polymeric Microneedle Arrays for Drug Delivery

2006 ◽  
Vol 950 ◽  
Author(s):  
Aleksandr Ovsianikov ◽  
Anand Doraiswamy ◽  
Roger Narayan ◽  
Boris N. Chichkov
Keyword(s):  
Drug Delivery ◽  
Three Dimensional ◽  
Skin Penetration ◽  
Two Photon ◽  
Novel Technology ◽  
Unique Approach ◽  
Microneedle Arrays ◽  
Pharmacologic Agents ◽  
Drug Delivery Devices

ABSTRACTTwo-photon polymerization (2PP) is a novel technology for the fabrication of complex three-dimensional (3D) microstructures. The number of applications employing this technology is rapidly increasing, and includes the fabrication of three-dimensional photonic crystals [1-4], medical devices, and scaffolds for tissue engineering [5, 6]. We have used 2PP to fabricate microneedle arrays with various geometries. These devices provide a unique approach for transdermal delivery of nucleic acid- and protein-based pharmacologic agents. Many of issues associated with conventional intravenous drug administration, including pain to the patient, trauma at the injection site, and difficulty in providing sustained release of a pharmacological agent, may be eliminated by applying the microneedles. The effect of microneedle geometry (e.g., tip sharpness and aspect ratio) on skin penetration was examined. Our results indicate that microneedles created using 2PP technique are suitable for in vivo use, and integration with next generation MEMS- and NEMS-based drug delivery devices.

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