Site Specific Controlled Release for Cardiovascular Disease: Translational Directions

2011 ◽  
pp. 445-492
Author(s):  
Ilia Fishbein ◽  
Michael Chorny ◽  
Ivan S. Alferiev ◽  
Robert J. Levy
Keyword(s):  
Cardiovascular Disease ◽  
Controlled Release ◽  
Site Specific

Synthesis of amphiphilic polysuccinimide star copolymers for responsive delivery in plants

2015 ◽  
Vol 51 (47) ◽  
pp. 9694-9697 ◽  
Author(s):  
Mingsheng Chen ◽  
Shaun P. Jensen ◽  
Megan R. Hill ◽  
Gloria Moore ◽  
Zhenli He ◽  
...  
Keyword(s):  
Controlled Release ◽  
Plant Cells ◽  
Delivery Methods ◽  
Site Specific ◽  
Star Copolymers ◽  
Novel Methods

While polymeric nano-carriers are widely used in medicine for controlled release and site-specific delivery, few reports have applied such delivery methods within agriculture. We report the synthesis of polymeric nano-carriers designed for delivery to the phloem of plants and describe novel methods for evaluating toxicity of polymers in plant cells.

Liposomes and immunoliposomes for controlled release or site specific delivery of anti-parasitic drugs and cytostatics

1991 ◽  
Vol 16 (1-2) ◽  
pp. 147-154 ◽  
Author(s):  
D.J.A. Crommelin ◽  
W.M.C. Eling ◽  
P.A. Steerenberg ◽  
U.K. Nässander ◽  
G. Storm ◽  
...  
Keyword(s):  
Controlled Release ◽  
Site Specific

scholarly journals Site-Specific Antioxidative Therapy for Prevention of Atherosclerosis and Cardiovascular Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-14 ◽  
Author(s):  
Hajime Otani
Keyword(s):  
Oxidative Stress ◽  
Cardiovascular Disease ◽  
Adipose Tissue ◽  
Cellular Biology ◽  
Healthy Life ◽  
Site Specific ◽  
Limited Success ◽  
Antioxidative Therapy ◽  
Prevention Of Atherosclerosis ◽  
Visceral Adipose

Oxidative stress has been implicated in pathophysiology of aging and age-associated disease. Antioxidative medicine has become a practice for prevention of atherosclerosis. However, limited success in preventing cardiovascular disease (CVD) in individuals with atherosclerosis using general antioxidants has prompted us to develop a novel antioxidative strategy to prevent atherosclerosis. Reducing visceral adipose tissue by calorie restriction (CR) and regular endurance exercise represents a causative therapy for ameliorating oxidative stress. Some of the recently emerging drugs used for the treatment of CVD may be assigned as site-specific antioxidants. CR and exercise mimetic agents are the choice for individuals who are difficult to continue CR and exercise. Better understanding of molecular and cellular biology of redox signaling will pave the way for more effective antioxidative medicine for prevention of CVD and prolongation of healthy life span.

scholarly journals Controlled release implants for cardiovascular disease

1990 ◽  
Vol 11 (1-3) ◽  
pp. 245-254 ◽  
Author(s):  
Robert J. Levy ◽  
Thomas P. Johnston ◽  
Amnon Sintov ◽  
Gershon Golomb
Keyword(s):  
Cardiovascular Disease ◽  
Controlled Release

scholarly journals Circulating levels of metabolic biomarkers of site-specific and sex-specific arterial calcification in the multi-cohort BBMRI setting

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M.M Bos ◽  
N.A Van Vliet ◽  
M Beekman ◽  
P.E Slagboom ◽  
M Vernooij ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Proton Nuclear Magnetic Resonance ◽  
Arterial Calcification ◽  
P Value ◽  
Funding Source ◽  
Atherosclerotic Cardiovascular Disease ◽  
Biological Mechanisms ◽  
Site Specific ◽  
Metabolic Biomarkers ◽  
Circulating Levels

Abstract Background/Introduction Increasing evidence shows that greater arterial calcification leads to an elevated risk of atherosclerotic cardiovascular disease. Risk factors and prognosis of arterial calcification seems to vary per site and between women and men. However, the underlying biological mechanisms of site-specific calcification and the associated sex differences are largely unknown. Within the BBMRI framework, we performed a multi-cohort study on the associations of the circulating levels of metabolic biomarkers with arterial calcification at various sites among women and men. Purpose To examine the associations of the circulating levels of metabolic biomarkers with coronary artery (CAC), aortic arch (AAC) and the aortic valve (AVC) calcifications among women and men. Methods We included a total of 1,114 participants from the population-based Rotterdam Study and 390 from the Leiden Longevity Study. Study populations were comparable concerning study characteristics. Blood samples were used to determine a wide range of plasma metabolic biomarkers by proton nuclear magnetic resonance (NMR). Participants underwent non-contrast computed tomography to quantify the volume of CAC, AAC, and AVC. Linear regression modelling adjusted for relevant covariates was used to assess the associations of 166 metabolic biomarkers with CAC, AAC, and AVC. Correction for multiple testing was based on 33 independent metabolic biomarkers (p-value 0.05/33 = 1.5 x 10–3). Results Mean (standard deviation - SD) age was 69.5 (6.8) and 780 (52.0%) of the study population were women. One SD increase in concentration of a1-acid glycoprotein, was associated with a 0.10 SD (standard error (SE) = 0.03) increase in AAC (p-value = 9.5x10–4) in the overall population (Figure 1). When we stratified our analyses based on sex, this association was mainly driven by men [beta (SE) per SD: 0.12 (0.05), p-value = 0.007]. Moreover, an SD increase in acetate was associated with a 0.14 SD (SE = 0.04) decrease in CAC (p-value 1.7x10–4) in women but not in men [beta (SE) per SD: −0.04 (0.03), p-value = 0.22] (Figure 1). Conclusion(s) Higher levels of circulating glycoproteins were associated with increased AAC in men. Moreover, lower levels of circulating acetate were associated with increased CAC in women. These results provide evidence for location-specific differences and sex-specific effects in the underlying biological mechanisms of atherosclerosis. Our findings carry the potential to contribute to the early detection of individuals at increased risk for developing atherosclerotic cardiovascular disease and to a better understanding of disease etiology. Figure 1 Funding Acknowledgement Type of funding source: Public grant(s) – National budget only. Main funding source(s): This work was performed within the framework of the BBMRI Metabolomics Consortium funded by BBMRI-NL, a research infrastructure financed by the Dutch government through Netherlands Organisation for Scientific Research (NWO) (Grant Nos. 184.021.007 and 184033111). MK was supported by VENI grant (91616079) from The Netherlands Organization for Health Research and Development (ZonMw).

pH-sensitive inulin-based nanomicelles for intestinal site-specific and controlled release of celecoxib

2018 ◽  
Vol 181 ◽  
pp. 570-578 ◽  
Author(s):  
Delia Mandracchia ◽  
Adriana Trapani ◽  
Sara Perteghella ◽  
Milena Sorrenti ◽  
Laura Catenacci ◽  
...  
Keyword(s):  
Controlled Release ◽  
Ph Sensitive ◽  
Site Specific
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