The STEP Trial, Monkey Trials, and the Future of T-Cell Vaccines

2013 ◽  
pp. 161-168
Author(s):  
W. David Wick ◽  
Otto O. Yang
Keyword(s):  
T Cell ◽  
Step Trial ◽  
The Future

What is the future of immunotherapy in multiple myeloma?

Blood ◽  
2020 ◽  
Vol 136 (22) ◽  
pp. 2491-2497
Author(s):  
Leo Rasche ◽  
Michael Hudecek ◽  
Hermann Einsele
Keyword(s):  
Multiple Myeloma ◽  
Monoclonal Antibodies ◽  
Stem Cell ◽  
T Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Cell Therapies ◽  
The Future

Abstract The treatment of multiple myeloma (MM) is currently being redefined by humoral and cellular immunotherapies. For decades, there was limited belief in immune-based anti-MM therapy as a result of the moderate graft-versus-myeloma effect of allogeneic stem cell transplantation. Today, monoclonal antibodies comprise the new backbone of anti-MM therapy, and T-cell therapies targeting BCMA are emerging as the most potent single agents for MM treatment. Herein, we present our assessment of and vision for MM immunotherapy in the short and midterm.

scholarly journals Host Genetic Determinants of T Cell Responses to the MRKAd5 HIV-1 gag/pol/nef Vaccine in the Step Trial

2011 ◽  
Vol 203 (6) ◽  
pp. 773-779 ◽  
Author(s):  
Jacques Fellay ◽  
Nicole Frahm ◽  
Kevin V. Shianna ◽  
Elizabeth T. Cirulli ◽  
Danilo R. Casimiro ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Responses ◽  
Genetic Determinants ◽  
Step Trial ◽  
Cell Responses ◽  
Host Genetic ◽  
Hiv 1

scholarly journals Back to the Future: Effector Fate during T Cell Exhaustion

Immunity ◽  
2019 ◽  
Vol 51 (6) ◽  
pp. 970-972 ◽  
Author(s):  
Veit R. Buchholz ◽  
Dirk H. Busch
Keyword(s):  
T Cell ◽  
T Cell Exhaustion ◽  
Cell Exhaustion ◽  
The Future
Sign in / Sign up

Export Citation Format

Share Document