Modulation of Developmental Signaling by the Proteostasis Network

2013 ◽  
pp. 203-228
Author(s):  
Kristin D. Patterson ◽  
Janice A. Fischer
Keyword(s):  
Developmental Signaling

scholarly journals Comparative approaches to the study of physiology: Drosophila as a physiological tool

2013 ◽  
Vol 304 (3) ◽  
pp. R177-R188 ◽  
Author(s):  
Wendi S. Neckameyer ◽  
Kathryn J. Argue
Keyword(s):  
Gene Expression ◽  
Drosophila Melanogaster ◽  
Pattern Formation ◽  
Signaling Pathways ◽  
Human Disease ◽  
Cognitive Disorders ◽  
Model System ◽  
Critical Questions ◽  
Developmental Signaling ◽  
Shed Light

Numerous studies have detailed the extensive conservation of developmental signaling pathways between the model system, Drosophila melanogaster, and mammalian models, but researchers have also profited from the unique and highly tractable genetic tools available in this system to address critical questions in physiology. In this review, we have described contributions that Drosophila researchers have made to mathematical dynamics of pattern formation, cardiac pathologies, the way in which pain circuits are integrated to elicit responses from sensation, as well as the ways in which gene expression can modulate diverse behaviors and shed light on human cognitive disorders. The broad and diverse array of contributions from Drosophila underscore its translational relevance to modeling human disease.

scholarly journals Enhancer priming enables fast and sustained transcriptional responses to Notch signaling

2018 ◽  
Author(s):  
Julia Falo-Sanjuan ◽  
Nicholas C Lammers ◽  
Hernan G Garcia ◽  
Sarah Bray
Keyword(s):  
Transcription Factors ◽  
Dynamic Response ◽  
Notch Signaling ◽  
Real Time ◽  
Single Cells ◽  
Transcriptional Responses ◽  
Sustained Activity ◽  
Developmental Signaling ◽  
Cellular Context ◽  
Nascent Transcripts

SummaryInformation from developmental signaling pathways must be accurately decoded to generate transcriptional outcomes. In the case of Notch, the intracellular domain (NICD) transduces the signal directly to the nucleus. How enhancers decipher NICD in the real time of developmental decisions is not known. Using the MS2/MCP system to visualize nascent transcripts in single cells in Drosophila embryos we reveal how two target enhancers read Notch activity to produce synchronized and sustained profiles of transcription. By manipulating the levels of NICD and altering specific motifs within the enhancers we uncover two key principles. First, increased NICD levels alter transcription by increasing duration rather than frequency of transcriptional bursts. Second, priming of enhancers by tissue-specific transcription factors is required for NICD to confer synchronized and sustained activity; in their absence, transcription is stochastic and bursty. The dynamic response of an individual enhancer to NICD thus differs depending on the cellular context.

scholarly journals Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways

2018 ◽  
Vol 25 (9) ◽  
pp. 1095-1106.e23 ◽  
Author(s):  
Silke Brand ◽  
Sayantani Roy ◽  
Peter Schröder ◽  
Bernd Rathmer ◽  
Jessica Roos ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
In Silico ◽  
Target Identification ◽  
Developmental Signaling

scholarly journals Communication codes in developmental signaling pathways

Development ◽  
2019 ◽  
Vol 146 (12) ◽  
pp. dev170977 ◽  
Author(s):  
Pulin Li ◽  
Michael B. Elowitz
Keyword(s):  
Signaling Pathways ◽  
Developmental Signaling

Developmental signaling genes in ameloblastoma

2014 ◽  
Vol 7 (1) ◽  
pp. 16-21
Author(s):  
K. Onyegbula ◽  
O. S. Onile ◽  
V. N. Okoje ◽  
C. I. Anumudu
Keyword(s):  
Developmental Signaling
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