Role of Proteases and Their Tissue Inhibitors in Pregnancy Outcome

2013 ◽  
pp. 277-287
Author(s):  
Sudhir C. Roy
Keyword(s):  
Pregnancy Outcome ◽  
Tissue Inhibitors ◽  
In Pregnancy

scholarly journals The Role of Thrombophilia in Pregnancy

Thrombosis ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Elisabeth M. Battinelli ◽  
Ariela Marshall ◽  
Jean M. Connors
Keyword(s):  
Pregnancy Outcome ◽  
Oral Anticoagulants ◽  
New Oral Anticoagulants ◽  
Thrombotic Disease ◽  
Therapeutic Anticoagulation ◽  
Physical Changes ◽  
The Impact ◽  
Physiologic Changes Of Pregnancy ◽  
In Pregnancy

Thrombotic disease is a major cause of peripartum morbidity and mortality worldwide. Development of thrombosis in pregnancy is multifactorial due to the physiologic changes of pregnancy—which induce a relative hypercoagulable state—as well as physical changes leading to increased stasis and also the effects of both the inherited and the acquired thrombophilias. In this review, we discuss the impact of each of these factors on the development of thrombosis as well as the evidence for the impact of pregnancy-associated thrombosis on pregnancy outcome. We then discuss the use of both prophylactic and therapeutic anticoagulation during pregnancy and the puerperium. We review the indications and dosing recommendations for administration of anticoagulation in a context of discussing the evidence including the lack of evidence and formal guidelines in this area. We briefly address the role of the new oral anticoagulants in pregnancy and conclude that significant further research in women with thrombophilias and pregnancy-associated thrombosis may help clarify the management of this condition in the future.

The role of advanced maternal age and newborn sex in pregnancy outcome

2013 ◽  
Vol 3 (4) ◽  
pp. 159-164 ◽  
Author(s):  
Alessandro Favilli ◽  
Silvia Pericoli ◽  
Gian Carlo Di Renzo ◽  
Sandro Gerli
Keyword(s):  
Pregnancy Outcome ◽  
Maternal Age ◽  
Advanced Maternal Age ◽  
In Pregnancy

Gestational Exposure to Serotonin Reuptake Inhibitors and Pregnancy Outcome ; Exploring the Role of Bias and Confounders

2020 ◽  
Vol 18 ◽  
Author(s):  
Gideon Koren Md Frcpc Facmt ◽  
Asher Ornoy
Keyword(s):  
Pregnancy Outcome ◽  
Congenital Malformations ◽  
Epidemiological Studies ◽  
Adverse Outcomes ◽  
Depression And Anxiety ◽  
Gestational Exposure ◽  
Fetal Safety ◽  
Meta Analyses ◽  
In Pregnancy

: There is no other example in human teratology where, after more than 40 epidemiological studies, repeated meta analyses and thousands of pregnancies, the fetal safety or risk of an agent has not been verified and settled. The objectives of the present review was to identify and discuss sources of bias that may lead clinicians and scientists to believe that SRI cause malformation or other adverse outcomes, where, in fact, they may not. The present study highlights sources of bias which may explain why children exposed in utero to SRI exhibit higher rates of congenital malformations, mostly cardiovascular and other complications. It appears that pregnant women treated for depression and anxiety are distinctively different from healthy women in numerous covariates which may confound pregnancy outcome. Acknowledging and adjusting for these sources of bias is critical before one selects to withhold therapy for moderate or severe cases of depression and anxiety in pregnancy.

The Role of Acetaldehyde in Pregnancy Outcome After Prenatal Alcohol Exposure

2001 ◽  
Vol 23 (4) ◽  
pp. 427-434 ◽  
Author(s):  
Marjie L. Hard ◽  
Thomas R. Einarson ◽  
Gideon Koren
Keyword(s):  
Pregnancy Outcome ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Prenatal Alcohol ◽  
In Pregnancy

Role of perinatal technologies in pregnancy outcome for fetus

2000 ◽  
Vol 70 ◽  
pp. B123-B123
Author(s):  
T. Gracheva ◽  
V. Saprikin ◽  
I. Dragun
Keyword(s):  
Pregnancy Outcome ◽  
In Pregnancy

Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

2015 ◽  
Vol 4 (3) ◽  
pp. 205 ◽  
Author(s):  
Shikha Saxena ◽  
KV Thimmaraju ◽  
PremC Srivastava ◽  
AyazK Mallick ◽  
Biswajit Das ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Pregnancy Induced Hypertension ◽  
Induced Hypertension ◽  
In Pregnancy

The role of matrix metalloproteinase 9 and its inhibitors in scarring processes following surgery for primary open-angle glaucoma

2019 ◽  
pp. 72-80
Author(s):  
Е.В. Маркелова ◽  
О.В. Овчинникова ◽  
А.С. Хохлова ◽  
Л.П. Догадова ◽  
А.В. Костюшко ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Postoperative Period ◽  
Open Angle Glaucoma ◽  
Matrix Metalloproteinase 9 ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Open Angle ◽  
Tissue Inhibitors ◽  
Surgery Outcome ◽  
Metalloproteinase 9

Оперативное вмешательство - один из основных методов лечения глаукомы. Однако развитие избыточного рубцевания созданных путей оттока определяет результат хирургического лечения в отдаленные сроки. Процессы рубцевания на данный момент недостаточно изучены. Цель исследования - оценка роли матриксной металлопротеиназы-9, ее ингибиторов в процессах рубцевания у больных с первичной открытоугольной глаукомой после оперативного лечения. Методика. Для выявления возможных маркеров избыточного рубцевания методом твердофазного иммуноферментного анализа определяли содержание матриксных металлопротеиназ-9, тканевых ингибиторов металлопротеиназ 2 и -3 в слезной жидкости у 37 пациентов с активной стадией первичной остроугольной глаукомы в динамике послеоперационного периода. Средний возраст пациентов составил 52,8 лет. В зависимости от исхода оперативного вмешательства все пациенты были разделены на 2 группы - с благоприятным исходом (без избыточного рубцевания) и с неблагоприятным исходом (с избыточным рубцеванием) на месте сформированных дополнительных путей оттока внутриглазной жидкости в послеоперационном периоде. Группа контроля включала 20 человек в возрасте от 50 до 66 лет без сопутствующей офтальмологической и соматической патологии в стадии обострения. Результаты. В динамике показано изменение концентрации матриксной металлопротеиназы-9 и ее ингибиторов в послеоперационном периоде. Анализ данных свидетельствует об обратной зависимости уровня матриксной металлопротеиназы-9 и тканевых ингибиторов металлопротеиназы 2 и 3 типов с исходом операции - чем выше концентрация металлопротеиназы-9 и ниже концентрация тканевых ингибиторов металлопротеиназ 2, -3 в слезной жидкости, тем выше вероятность неблагоприятного исхода в виде рубцевания сформированных дополнительных путей оттока внутриглазной жидкости в послеоперационном периоде. Заключение. Мониторинг уровня металлопротеиназ и их тканевых ингибиторов после проведения хирургического лечения пациентов с первичной открытоугольной глаукомой позволяет прогнозировать раннее рубцевание, дает возможность разработки новых методов лечения как в раннем, так и в позднем послеоперационном периоде. Surgery is one of the major treatments for glaucoma; however excessive scarring of created outflow patways affects the long-term outcome. At the present time, scarring processes are not sufficiently studied. Aim. To evaluate the role of matrix metalloproteinase 9 and its inhibitors in scarring after surgical treatment of open-angle glaucoma. Methods. Concentrations of matrix metalloproteinase 9 and tissue inhibitors of metalloproteinases 2 and 3 were measured in tear fluid of 37 patients (mean age, 52.8) with active primary open-angle glaucoma in dynamics during the postoperative period to identify possible markers of excessive scarring. Based on the surgery outcome, all patients were divided into two groups, with a favorable outcome (without excessive scarring) and an unfavorable outcome (with excessive scarring) in the created additional outflow pathways for the intraocular fluid in the postoperative period. The control group included 20 subjects aged 50-66 without eye disease or somatic disease at exacerbation stage. Results. Analysis of changes in concentrations of matrix metalloproteinase 9 and its inhibitors in the postoperative period showed their inverse relationship with the surgery outcome. The higher was the metalloproteinase 9 level and the lower the level of tissue inhibitors of metalloproteinases 2 and 3 the higher was the probability of unfavorable outcome evident as excessive scarring of the formed additional pathways for tear fluid outflow in the postoperative period. Conclusion. Postoperative monitoring of metalloproteinases and their tissue inhibitors allows to predict early scarring and to develop new treatments both in early and late postoperative periods.

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