The role of advanced maternal age and newborn sex in pregnancy outcome

2013 ◽  
Vol 3 (4) ◽  
pp. 159-164 ◽  
Author(s):  
Alessandro Favilli ◽  
Silvia Pericoli ◽  
Gian Carlo Di Renzo ◽  
Sandro Gerli
Keyword(s):  
Pregnancy Outcome ◽  
Maternal Age ◽  
Advanced Maternal Age ◽  
In Pregnancy

Does advanced maternal age affect pregnancy outcome in women with mild hypertension remote from term?

1997 ◽  
Vol 176 (6) ◽  
pp. 1236-1243 ◽  
Author(s):  
John R. Barton ◽  
Niki K. Bergauer ◽  
Debbie L. Jacques ◽  
Suzanne K. Coleman ◽  
Gary J Stanziano ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Maternal Age ◽  
Mild Hypertension ◽  
Advanced Maternal Age

scholarly journals Preimplantation Genetic Screening: An Effective Testing for Infertile and Repeated Miscarriage Patients?

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Ning Wang ◽  
Ying-Ming Zheng ◽  
Lei Li ◽  
Fan Jin
Keyword(s):  
Genetic Screening ◽  
Poor Prognosis ◽  
Maternal Age ◽  
Randomized Trials ◽  
Preimplantation Genetic Screening ◽  
Advanced Maternal Age ◽  
Aneuploidy Screening ◽  
Good Target ◽  
The World ◽  
In Pregnancy

Aneuploidy in pregnancy is known to increase with advanced maternal age (AMA) and associate with repeated implantation failure (RIF), and repeated miscarriage (RM). Preimplantation genetic screening (PGS) has been introduced into clinical practice, screening, and eliminating aneuploidy embryos, which can improve the chance of conceptions for infertility cases with poor prognosis. These patients are a good target group to assess the possible benefit of aneuploidy screening. Although practiced widely throughout the world, there still exist some doubts about the efficacy of this technique. Recent randomized trials were not as desirable as we expected, suggesting that PGS needs to be reconsidered. The aim of this review is to discuss the efficacy of PGS.

scholarly journals Timing of blastocyst development is the sole predictor of positive pregnancy outcome in advanced maternal age patients following single euploid blastocyst transfer

2019 ◽  
Vol 112 (3) ◽  
pp. e157
Author(s):  
Mandy G. Katz-Jaffe ◽  
Annette Matts ◽  
Amy Bartoli ◽  
Diane Klepacka ◽  
Danielle Young ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Maternal Age ◽  
Advanced Maternal Age ◽  
Blastocyst Transfer ◽  
Blastocyst Development

Advanced maternal age and pregnancy outcome – a review of 39,683 births

2016 ◽  
Vol 206 ◽  
pp. e22-e23
Author(s):  
Mandy Caruana ◽  
Miriam Gatt ◽  
Yves Oscar Muscat Baraon
Keyword(s):  
Pregnancy Outcome ◽  
Maternal Age ◽  
Advanced Maternal Age

scholarly journals The Role of Thrombophilia in Pregnancy

Thrombosis ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Elisabeth M. Battinelli ◽  
Ariela Marshall ◽  
Jean M. Connors
Keyword(s):  
Pregnancy Outcome ◽  
Oral Anticoagulants ◽  
New Oral Anticoagulants ◽  
Thrombotic Disease ◽  
Therapeutic Anticoagulation ◽  
Physical Changes ◽  
The Impact ◽  
Physiologic Changes Of Pregnancy ◽  
In Pregnancy

Thrombotic disease is a major cause of peripartum morbidity and mortality worldwide. Development of thrombosis in pregnancy is multifactorial due to the physiologic changes of pregnancy—which induce a relative hypercoagulable state—as well as physical changes leading to increased stasis and also the effects of both the inherited and the acquired thrombophilias. In this review, we discuss the impact of each of these factors on the development of thrombosis as well as the evidence for the impact of pregnancy-associated thrombosis on pregnancy outcome. We then discuss the use of both prophylactic and therapeutic anticoagulation during pregnancy and the puerperium. We review the indications and dosing recommendations for administration of anticoagulation in a context of discussing the evidence including the lack of evidence and formal guidelines in this area. We briefly address the role of the new oral anticoagulants in pregnancy and conclude that significant further research in women with thrombophilias and pregnancy-associated thrombosis may help clarify the management of this condition in the future.

Mitochondrial SIRT5 is present in follicular cells and is altered by reduced ovarian reserve and advanced maternal age

2014 ◽  
Vol 26 (8) ◽  
pp. 1072 ◽  
Author(s):  
Leanne Pacella-Ince ◽  
Deirdre L. Zander-Fox ◽  
Michelle Lane
Keyword(s):  
Follicular Fluid ◽  
Ovarian Reserve ◽  
Protein Function ◽  
Maternal Age ◽  
Cumulus Cells ◽  
Advanced Maternal Age ◽  
Oocyte Quality ◽  
Carbamoyl Phosphate ◽  
Protein Activity

Women with reduced ovarian reserve or advanced maternal age have an altered metabolic follicular microenvironment. As sirtuin 5 (SIRT5) senses cellular metabolic state and post-translationally alters protein function, its activity may directly impact on oocyte viability and pregnancy outcome. Therefore, we investigated the role of SIRT5 in relation to ovarian reserve and maternal age. Women (n = 47) undergoing routine IVF treatment were recruited and allocated to one of three cohorts based on ovarian reserve and maternal age. Surplus follicular fluid, granulosa and cumulus cells were collected. SIRT5 mRNA, protein and protein activity was confirmed in granulosa and cumulus cells via qPCR, immunohistochemistry, western blotting and desuccinylation activity. The presence of carbamoyl phosphate synthase I (CPS1), a target of SIRT5, was investigated by immunohistochemistry and follicular-fluid ammonium concentrations determined via microfluorometry. Women with reduced ovarian reserve or advanced maternal age had decreased SIRT5 mRNA, protein and desuccinylation activity in granulosa and cumulus cells resulting in an accumulation of follicular-fluid ammonium, presumably via alterations in activity of a SIRT5 target, CPS1, which was present in granulosa and cumulus cells. This suggests a role for SIRT5 in influencing oocyte quality and IVF outcomes.

scholarly journals Advanced Maternal Age and Adverse Pregnancy Outcome: Evidence from a Large Contemporary Cohort

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56583 ◽  
Author(s):  
Louise C. Kenny ◽  
Tina Lavender ◽  
Roseanne McNamee ◽  
Sinéad M. O’Neill ◽  
Tracey Mills ◽  
...  
Keyword(s):  
Pregnancy Outcome ◽  
Maternal Age ◽  
Adverse Pregnancy Outcome ◽  
Advanced Maternal Age ◽  
Adverse Pregnancy
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