Adult Stem Cells: Adult Skeletal Muscle Stem Cells

2013 ◽  
pp. 31-45
Author(s):  
Jinhong Meng ◽  
Jennifer E. Morgan
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Adult Stem Cells ◽  
Adult Skeletal Muscle ◽  
Muscle Stem Cells ◽  
Skeletal Muscle Stem Cells

scholarly journals Myf5 haploinsufficiency reveals distinct cell fate potentials for adult skeletal muscle stem cells

Development ◽  
2012 ◽  
Vol 139 (12) ◽  
pp. e1208-e1208
Author(s):  
B. Gayraud-Morel ◽  
F. Chretien ◽  
A. Jory ◽  
R. Sambasivan ◽  
E. Negroni ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Cell Fate ◽  
Adult Skeletal Muscle ◽  
Muscle Stem Cells ◽  
Distinct Cell ◽  
Skeletal Muscle Stem Cells

scholarly journals Transcriptional Reprogramming of Skeletal Muscle Stem Cells by the Niche Environment

2021 ◽  
Author(s):  
Felicia Lazure ◽  
Rick Farouni ◽  
Korin Sahinyan ◽  
Darren M. Blackburn ◽  
Aldo Hernandez-Corchado ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Tissue Regeneration ◽  
Adult Stem Cells ◽  
Cell Function ◽  
Chromatin Accessibility ◽  
Muscle Stem Cells ◽  
Age Related ◽  
A Genome ◽  
Skeletal Muscle Stem Cells

Adult stem cells are indispensable for tissue regeneration. Tissue-specific stem cells reside in a specialized location called their niche, where they are in constant cross talk with neighboring niche cells and circulatory signals from their environment. Aging has a detrimental effect on the number and the regenerative function of various stem cells. However, whether the loss of stem cell function is a cause or consequence of their aging niche is unclear. Using skeletal muscle stem cells (MuSCs) as a model, we decouple cell-intrinsic from niche-mediated extrinsic effects of aging on their transcriptome. By combining in vivo MuSC heterochronic transplantation models and computational methods, we show that on a genome-wide scale, age-related altered genes fall into two distinct categories regarding their response to the niche environment. Genes that are inelastic in their response to the niche exhibit altered chromatin accessibility and are associated with differentially methylated regions (DMRs) between young and aged cells. On the other hand, genes that are restorable by niche exposure exhibit altered transcriptome but show no change in chromatin accessibility or DMRs. Taken together, our data suggest that the niche environment plays a decisive role in controlling the transcriptional activity of MuSCs, and exposure to a young niche can reverse approximately half of all age-associated changes that are not epigenetically encoded. The muscle niche therefore serves as an important therapeutic venue to mitigate the negative consequence of aging on tissue regeneration.

scholarly journals Tubastatin A maintains adult skeletal muscle stem cells in a quiescent state ex vivo and improves their engraftment ability in vivo

2022 ◽  
Vol 17 (1) ◽  
pp. 82-95
Author(s):  
Marina Arjona ◽  
Armon Goshayeshi ◽  
Cristina Rodriguez-Mateo ◽  
Jamie O. Brett ◽  
Pieter Both ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Stem Cells ◽  
Ex Vivo ◽  
Quiescent State ◽  
Adult Skeletal Muscle ◽  
Muscle Stem Cells ◽  
Skeletal Muscle Stem Cells
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