Sensory Determinants of Hippocampal Place Cell Firing Fields

2002 ◽  
pp. 1-22 ◽  
Author(s):  
Robert U. Muller ◽  
Bruno Poucet ◽  
Bruno Rivard
Keyword(s):  
Place Cell ◽  
Cell Firing ◽  
Hippocampal Place Cell

scholarly journals Altered hippocampal place cell representation and theta rhythmicity following moderate prenatal alcohol exposure

2020 ◽  
Author(s):  
Ryan E. Harvey ◽  
Laura E. Berkowitz ◽  
Daniel D. Savage ◽  
Derek A. Hamilton ◽  
Benjamin J. Clark
Keyword(s):  
Spatial Memory ◽  
Prenatal Alcohol Exposure ◽  
Alcohol Exposure ◽  
Place Cell ◽  
Place Cells ◽  
Spatial Tuning ◽  
Cell Firing ◽  
Prenatal Alcohol ◽  
Ca3 Neurons ◽  
Hippocampal Place Cell

SummaryPrenatal alcohol exposure (PAE) leads to profound deficits in spatial memory and synaptic and cellular alterations to the hippocampus that last into adulthood. Neurons in the hippocampus, called place cells, discharge as an animal enters specific places in an environment, establish distinct ensemble codes for familiar and novel places, and are modulated by local theta rhythms. Spatial memory is thought to critically depend on the integrity of hippocampal place cell firing. We therefore tested the hypothesis that hippocampal place cell firing is impaired after PAE by performing in-vivo recordings from the hippocampi (CA1 and CA3) of moderate PAE and control adult rats. Our results show that hippocampal CA3 neurons from PAE rats have reduced spatial tuning. Secondly, CA1 and CA3 neurons from PAE rats are less likely to orthogonalize their firing between directions of travel on a linear track and between contexts in an open arena compared to control neurons. Lastly, reductions in the number of hippocampal place cells exhibiting significant theta rhythmicity and phase precession were observed which may suggest changes to hippocampal microcircuit function. Together, the reduced spatial tuning and sensitivity to context provides a neural systems-level mechanism to explain spatial memory impairment after moderate PAE.

scholarly journals Spatial Navigation and Hippocampal Place Cell Firing: The Problem of Goal Encoding

2004 ◽  
Vol 15 (2) ◽  
Author(s):  
Β. Poucet ◽  
P.P. Lenck-Santini ◽  
V. Hok ◽  
E. Save ◽  
J.P. Banquet ◽  
...  
Keyword(s):  
Spatial Navigation ◽  
Place Cell ◽  
Cell Firing ◽  
Hippocampal Place Cell

scholarly journals Hippocampal Place Cell Firing Patterns Can Induce Long-Term Synaptic Plasticity In Vitro

2009 ◽  
Vol 29 (21) ◽  
pp. 6840-6850 ◽  
Author(s):  
J. T. R. Isaac ◽  
K. A. Buchanan ◽  
R. U. Muller ◽  
J. R. Mellor
Keyword(s):  
Synaptic Plasticity ◽  
Place Cell ◽  
Firing Patterns ◽  
Cell Firing ◽  
Hippocampal Place Cell

scholarly journals Conjoint Control of Hippocampal Place Cell Firing by Two Visual Stimuli

2000 ◽  
Vol 116 (2) ◽  
pp. 191-210 ◽  
Author(s):  
André A. Fenton ◽  
Gyorgy Csizmadia ◽  
Robert U. Muller
Keyword(s):  
Visual Stimuli ◽  
Cell Activity ◽  
Place Cell ◽  
Sensory Stimuli ◽  
Local Arrangement ◽  
Cell Firing ◽  
Selected Subset ◽  
Environmental Representation ◽  
Hippocampal Place Cell ◽  
Made In

To better understand how hippocampal place cell activity is controlled by sensory stimuli, and to further elucidate the nature of the environmental representation provided by place cells, we have made recordings in the presence of two distinct visual stimuli under standard conditions and after several manipulations of these stimuli. In line with a great deal of earlier work, we find that place cell activity is constant when repeated recordings are made in the standard conditions in which the centers of the two stimuli, a black card and a white card, are separated by 135° on the wall of a cylindrical recording chamber. Rotating the two stimuli by 45° causes equal rotations of place cell firing fields. Removing either card and rotating the other card also causes fields to rotate equally, showing that the two stimuli are individually salient. Increasing or decreasing the card separation (card reconfiguration) causes a topological distortion of the representation of the cylinder floor such that field centers move relative to each other. We also found that either kind of reconfiguration induces a position-independent decrease in the intensity of place cell firing. We argue that these results are not compatible with either of two previously stated views of the place cell representation; namely, a nonspatial theory in which each place cell is tuned to an arbitrarily selected subset of available stimuli or a rigid map theory. We propose that our results imply that the representation is map-like but not rigid; it is capable of undergoing stretches without altering the local arrangement of firing fields.

Experience-dependent modifications of hippocampal place cell firing

Hippocampus ◽  
1991 ◽  
Vol 1 (2) ◽  
pp. 193-205 ◽  
Author(s):  
Elizabeth Bostock ◽  
Robert U. Muller ◽  
John L. Kubie
Keyword(s):  
Place Cell ◽  
Cell Firing ◽  
Hippocampal Place Cell

scholarly journals Social observation enhances cross-environment activation of hippocampal place cell patterns

eLife ◽  
2016 ◽  
Vol 5 ◽  
Author(s):  
Xiang Mou ◽  
Daoyun Ji
Keyword(s):  
Spatial Representation ◽  
Spatial Information ◽  
Place Cell ◽  
Neural Mechanisms ◽  
Local Enhancement ◽  
Neural Basis ◽  
Social Observation ◽  
Cell Patterns ◽  
Cell Firing ◽  
Hippocampal Place Cell

Humans and animals frequently learn through observing or interacting with others. The local enhancement theory proposes that presence of social subjects in an environment facilitates other subjects' understanding of the environment. To explore the neural basis of this theory, we examined hippocampal place cells, which represent spatial information, in rats as they stayed in a small box while a demonstrator rat running on a separate, nearby linear track, and as they ran on the same track themselves. We found that place cell firing sequences during self-running on the track also appeared in the box. This cross-environment activation occurred even prior to any self-running experience on the track and was absent without a demonstrator. Our data thus suggest that social observation can facilitate the observer’s spatial representation of an environment without actual self-exploration. This finding may contribute to neural mechanisms of local enhancement.

scholarly journals Prefrontal Cortex Focally Modulates Hippocampal Place Cell Firing Patterns

2013 ◽  
Vol 33 (8) ◽  
pp. 3443-3451 ◽  
Author(s):  
V. Hok ◽  
E. Chah ◽  
E. Save ◽  
B. Poucet
Keyword(s):  
Prefrontal Cortex ◽  
Place Cell ◽  
Firing Patterns ◽  
Cell Firing ◽  
Hippocampal Place Cell
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