UV Treatment of Skin: Effect on Langerhans Cells and HSV-1 Infection

1991 ◽  
pp. 203-220
Author(s):  
Tomoko Otani-Tanahashi ◽  
Ryoichi Mori
Keyword(s):  
Langerhans Cells ◽  
Skin Effect ◽  
Uv Treatment ◽  
Hsv 1

Skin Langerhans cells play an essential role in the defense against HSV-1 infection

1986 ◽  
Vol 91 (3-4) ◽  
pp. 341-349 ◽  
Author(s):  
E. Sprecher ◽  
Y. Becker
Keyword(s):  
Langerhans Cells ◽  
Essential Role ◽  
Hsv 1

scholarly journals Herpes Simplex Virus type 1 infects Langerhans cells and the novel epidermal dendritic cell, Epi-cDC2s, via different entry pathways

2021 ◽  
Vol 17 (4) ◽  
pp. e1009536
Author(s):  
Kirstie M. Bertram ◽  
Naomi R. Truong ◽  
Jacinta B. Smith ◽  
Min Kim ◽  
Kerrie J. Sandgren ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Langerhans Cells ◽  
Vaccine Development ◽  
Mononuclear Phagocytes ◽  
The Novel ◽  
Endosomal Acidification ◽  
Simplex Virus ◽  
Hsv 1

Skin mononuclear phagocytes (MNPs) provide the first interactions of invading viruses with the immune system. In addition to Langerhans cells (LCs), we recently described a second epidermal MNP population, Epi-cDC2s, in human anogenital epidermis that is closely related to dermal conventional dendritic cells type 2 (cDC2) and can be preferentially infected by HIV. Here we show that in epidermal explants topically infected with herpes simplex virus (HSV-1), both LCs and Epi-cDC2s interact with HSV-1 particles and infected keratinocytes. Isolated Epi-cDC2s support higher levels of infection than LCs in vitro, inhibited by acyclovir, but both MNP subtypes express similar levels of the HSV entry receptors nectin-1 and HVEM, and show similar levels of initial uptake. Using inhibitors of endosomal acidification, actin and cholesterol, we found that HSV-1 utilises different entry pathways in each cell type. HSV-1 predominantly infects LCs, and monocyte-derived DCs, via a pH-dependent pathway. In contrast, Epi-cDC2s are mainly infected via a pH-independent pathway which may contribute to the enhanced infection of Epi-cDC2s. Both cells underwent apoptosis suggesting that Epi-cDC2s may follow the same dermal migration and uptake by dermal DCs that we have previously shown for LCs. Thus, we hypothesize that the uptake of HSV and infection of Epi-cDC2s will stimulate immune responses via a different pathway to LCs, which in future may help guide HSV vaccine development and adjuvant targeting.

UV Treatment of the Skin and HSV-1 Infection

1991 ◽  
pp. 221-239
Author(s):  
Sarah E.M. Howie ◽  
James A. Ross
Keyword(s):  
Uv Treatment ◽  
Hsv 1

Dendritic cells of the human epidermis: immuno-electron microscopic studies of la antigen reactivity

1978 ◽  
Vol 36 (2) ◽  
pp. 644-645
Author(s):  
G. Rowden ◽  
M. G. Lewis ◽  
T. M. Phillips
Keyword(s):  
Dendritic Cells ◽  
Langerhans Cells ◽  
Cell Types ◽  
Cell Type ◽  
Electron Microscopic ◽  
La Antigen ◽  
Microscopic Studies ◽  
A Cell ◽  
C3 Receptors ◽  
Antigen Reactivity

Langerhans cells of mammalian stratified squamous epithelial have proven to be an enigma since their discovery in 1868. These dendritic suprabasal cells have been considered as related to melanocytes either as effete cells, or as post divisional products. Although grafting experiments seemed to demonstrate the independence of the cell types, much confusion still exists. The presence in the epidermis of a cell type with morphological features seemingly shared by melanocytes and Langerhans cells has been especially troublesome. This so called "indeterminate", or " -dendritic cell" lacks both Langerhans cells granules and melanosomes, yet it is clearly not a keratinocyte. Suggestions have been made that it is related to either Langerhans cells or melanocyte. Recent studies have unequivocally demonstrated that Langerhans cells are independent cells with immune function. They display Fc and C3 receptors on their surface as well as la (immune region associated) antigens.

Assembly of VP26 in herpes simplex virus-1 capsid implicated by 3-D structure of recombinant capsid

1995 ◽  
Vol 53 ◽  
pp. 840-841
Author(s):  
Z. Hong Zhou ◽  
Jing He ◽  
Joanita Jakana ◽  
J. D. Tatman ◽  
Frazer J. Rixon ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
3D Structure ◽  
Structure Study ◽  
Herpes Simplex Virus 1 ◽  
Shell Proteins ◽  
Life Threatening ◽  
Infected Cells ◽  
Simplex Virus ◽  
Hsv 1

Herpes simplex virus-1 (HSV-1) is a ubiquitous virus which is implicated in diseases ranging from self-curing cold sores to life-threatening infections. The 2500 Å diameter herpes virion is composed of a glycoprotein spike containing, lipid envelope, enclosing a protein layer (the tegument) in which is embedded the capsid (which contains the dsDNA genome). The B-, and A- and C-capsids, representing different morphogenetic stages in HSV-1 infected cells, are composed of 7, and 5 structural proteins respectively. The three capsid types are organized in similar T=16 icosahedral shells with 12 pentons, 150 hexons, and 320 connecting triplexes. Our previous 3D structure study at 26 Å revealed domain features of all these structural components and suggested probable locations for the outer shell proteins, VP5, VP26, VP19c and VP23. VP5 makes up most of both pentons and hexons. VP26 appeared to bind to the VP5 subunit in hexon but not to that in penton.

In vitro primary sensitization of hapten-specific T cells by cultured human epidermal Langerhans cells - a screening predictive assay for contact sensitizers

1996 ◽  
Vol 26 (5) ◽  
pp. 563-570 ◽  
Author(s):  
M. KRASTEVA ◽  
J. PEGUET-NAVARRO ◽  
C. MOULON ◽  
P. COURTELLEMONT ◽  
G. REDZINIAK ◽  
...  
Keyword(s):  
T Cells ◽  
Langerhans Cells ◽  
Primary Sensitization ◽  
Predictive Assay ◽  
Epidermal Langerhans Cells

HSV-1 Is Likely Cause of New Genital Infections

2005 ◽  
Vol 36 (8) ◽  
pp. 40
Author(s):  
ELIZABETH MECHCATIE
Keyword(s):  
Genital Infections ◽  
Hsv 1

Langerhans Cells After Transplant Predict GVHD

2009 ◽  
Vol 40 (5) ◽  
pp. 4
Author(s):  
BRUCE JANCIN
Keyword(s):  
Langerhans Cells

Influence of local progesterone on the number of langerhans cells in human vaginal epithelium

1998 ◽  
Vol 5 (1) ◽  
pp. 91A-91A ◽  
Author(s):  
F WIESER ◽  
J HOSMANN ◽  
K CZERWENKA ◽  
W TSCHUGGUEL ◽  
K PISCHINGER ◽  
...  
Keyword(s):  
Langerhans Cells ◽  
Vaginal Epithelium

Early plasmapheresis in 3 consecutive cases of choreo-athetotic movement disorder after HSV-1 encephalitis

2011 ◽  
Vol 42 (S 01) ◽  
Author(s):  
I Lanator ◽  
M Freilinger ◽  
D Csaicsich ◽  
R Seidl ◽  
MT Schmook
Keyword(s):  
Movement Disorder ◽  
Hsv 1
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