Pituitary Tumor Transforming Gene (PTTG) of human is known as a checkpoint gene in
the middle and late stages of mitosis, and is also a proto-oncogene that promotes cell cycle
progression. In the nucleus, PTTG works as securin in controlling the mid-term segregation of
sister chromatids. Overexpression of PTTG, entering the nucleus with the help of PBF in pituitary
adenomas, participates in the regulation of cell cycle, interferes with DNA repair, induces genetic
instability, transactivates FGF-2 and VEGF and promotes angiogenesis and tumor invasion.
Simultaneously, overexpression of PTTG induces tumor cell senescence through the DNA damage
pathway, making pituitary adenoma possessing the potential self-limiting ability. To elucidate the
mechanism of PTTG in the regulation of pituitary adenomas, we focus on both the positive and
negative function of PTTG and find out key factors interacted with PTTG in pituitary adenomas.
Furthermore, we discuss other possible mechanisms correlate with PTTG in pituitary adenoma
initiation and development and the potential value of PTTG in clinical treatment.
Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases
