Mouse Mutations in the Study of Cerebellar Development

1999 ◽  
pp. 63-97
Author(s):  
Domna Karagogeos ◽  
Ourania Pavlou
Keyword(s):  
Cerebellar Development

Preterm Birth and Disruptive Cerebellar Development: Assessment of Perinatal Risk Factors

2006 ◽  
Vol 210 (S 5) ◽  
Author(s):  
A Messerschmidt ◽  
D Prayer ◽  
PC Brugger ◽  
G Zoder ◽  
W Sterniste ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Cerebellar Development ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Development Assessment

scholarly journals The long noncoding RNA Synage regulates synapse stability and neuronal function in the cerebellum

2021 ◽  
Author(s):  
Fei Wang ◽  
Qianqian Wang ◽  
Baowei Liu ◽  
Lisheng Mei ◽  
Sisi Ma ◽  
...  
Keyword(s):  
Noncoding Rna ◽  
Cerebellar Atrophy ◽  
Synaptic Activity ◽  
Motor Dysfunction ◽  
Cerebellar Development ◽  
Full Spectrum ◽  
Density Reduction ◽  
Adult Mice ◽  
Synapse Density ◽  
And Function

AbstractThe brain is known to express many long noncoding RNAs (lncRNAs); however, whether and how these lncRNAs function in modulating synaptic stability remains unclear. Here, we report a cerebellum highly expressed lncRNA, Synage, regulating synaptic stability via at least two mechanisms. One is through the function of Synage as a sponge for the microRNA miR-325-3p, to regulate expression of the known cerebellar synapse organizer Cbln1. The other function is to serve as a scaffold for organizing the assembly of the LRP1-HSP90AA1-PSD-95 complex in PF-PC synapses. Although somewhat divergent in its mature mRNA sequence, the locus encoding Synage is positioned adjacent to the Cbln1 loci in mouse, rhesus macaque, and human, and Synage is highly expressed in the cerebella of all three species. Synage deletion causes a full-spectrum cerebellar ablation phenotype that proceeds from cerebellar atrophy, through neuron loss, on to synapse density reduction, synaptic vesicle loss, and finally to a reduction in synaptic activity during cerebellar development; these deficits are accompanied by motor dysfunction in adult mice, which can be rescued by AAV-mediated Synage overexpression from birth. Thus, our study demonstrates roles for the lncRNA Synage in regulating synaptic stability and function during cerebellar development.

scholarly journals Novel role of Rac-Mid1 signaling in medial cerebellar development

Development ◽  
2017 ◽  
Vol 144 (10) ◽  
pp. 1863-1875 ◽  
Author(s):  
Takashi Nakamura ◽  
Takehiko Ueyama ◽  
Yuzuru Ninoyu ◽  
Hirofumi Sakaguchi ◽  
Narantsog Choijookhuu ◽  
...  
Keyword(s):  
Cerebellar Development

Dynamic Expression and New Functions of Early B Cell Factor 2 in Cerebellar Development

2019 ◽  
Vol 18 (6) ◽  
pp. 999-1010
Author(s):  
Aurora Badaloni ◽  
Filippo Casoni ◽  
Laura Croci ◽  
Francesca Chiara ◽  
Antonella Bizzoca ◽  
...  
Keyword(s):  
B Cell ◽  
Cerebellar Development ◽  
Dynamic Expression ◽  
Early B Cell Factor

scholarly journals Common Regulatory Targets of NFIA, NFIX and NFIB during Postnatal Cerebellar Development

2019 ◽  
Vol 19 (1) ◽  
pp. 89-101 ◽  
Author(s):  
James Fraser ◽  
Alexandra Essebier ◽  
Alexander S. Brown ◽  
Raul Ayala Davila ◽  
Danyon Harkins ◽  
...  
Keyword(s):  
Cerebellar Development

scholarly journals Protein kinase N1 critically regulates cerebellar development and long-term function

2018 ◽  
Vol 128 (5) ◽  
pp. 2076-2088 ◽  
Author(s):  
Stephanie zur Nedden ◽  
Rafaela Eith ◽  
Christoph Schwarzer ◽  
Lucia Zanetti ◽  
Hartwig Seitter ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Cerebellar Development ◽  
Term Function

Postnatal Effects of Retinoic Acid on Cerebellar Development

1999 ◽  
Vol 21 (2) ◽  
pp. 141-146 ◽  
Author(s):  
Miyuki Yamamoto ◽  
David Ullman ◽  
Ursula C Dräger ◽  
Peter Mccaffery
Keyword(s):  
Retinoic Acid ◽  
Cerebellar Development

Changes of Ganglioside Pattern During Cerebellar Development of Normal and Staggerer Mice

1985 ◽  
Vol 45 (2) ◽  
pp. 544-551 ◽  
Author(s):  
Heiner Schaal ◽  
Christiane Wille ◽  
Wolfgang Wile
Keyword(s):  
Cerebellar Development
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