scholarly journals Cytochrome P450, peroxisome proliferation, and cytoplasmic fatty acid-binding protein content in liver, heart and kidney of the diabetic rat

1999 ◽  
pp. 53-61 ◽  
Author(s):  
Wim Engels ◽  
Marc van Bilsen ◽  
Bruce H. R. Wolffenbuttel ◽  
Ger J. van der Vusse ◽  
Jan F. C. Glatz
Keyword(s):  
Cytochrome P450 ◽  
Fatty Acid ◽  
Protein Content ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Diabetic Rat ◽  
Peroxisome Proliferation ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Modulation of fatty acid-binding protein content of adult rat heart in response to chronic changes in plasma lipid levels

1993 ◽  
Vol 123 (1-2) ◽  
pp. 107-112 ◽  
Author(s):  
A. Garnier ◽  
C. Poizat ◽  
C. Keriel ◽  
P. Cuchet ◽  
M. M. Vork ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Protein Content ◽  
Rat Heart ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Plasma Lipid ◽  
Lipid Levels ◽  
Fatty Acid Binding ◽  
Adult Rat ◽  
Acid Binding Protein

Rat Heart Fatty Acid-Binding Protein Content Is Increased in Experimental Diabetes

1994 ◽  
Vol 199 (2) ◽  
pp. 639-646 ◽  
Author(s):  
J.F.C. Glatz ◽  
E. Vanbreda ◽  
H.A. Keizer ◽  
Y.F. Dejong ◽  
J.R.T. Lakey ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Protein Content ◽  
Rat Heart ◽  
Fatty Acid Binding Protein ◽  
Experimental Diabetes ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

scholarly journals Interaction of LY171883 and other peroxisome proliferators with fatty-acid-binding protein isolated from rat liver

1991 ◽  
Vol 280 (2) ◽  
pp. 387-391 ◽  
Author(s):  
J R Cannon ◽  
P I Eacho
Keyword(s):  
Fatty Acids ◽  
Oleic Acid ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Clofibric Acid ◽  
Peroxisome Proliferation ◽  
Peroxisome Proliferators ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Fatty-acid-binding protein (FABP) is a 14 kDa protein found in hepatic cytosol which binds and transports fatty acids and other hydrophobic ligands throughout the cell. The purpose of this investigation was to determine whether LY171883, a leukotriene D4 antagonist, and other peroxisome proliferators bind to FABP and displace an endogenous fatty acid. [3H]Oleic acid was used to monitor the elution of FABP during chromatographic purification. [14C]LY171883 had a similar elution profile when substituted in the purification, indicating a common interaction with FABP. LY171883 and its structural analogue, LY189585, as well as the hypolipidaemic peroxisome proliferators clofibric acid, ciprofibrate, bezafibrate and WY14,643, displaced [3H]oleic acid binding to FABP. Analogues of LY171883 that do not induce peroxisome proliferation only weakly displaced oleate binding. [3H]Ly171883 bound directly to FABP with a Kd of 10.8 microM, compared with a Kd of 0.96 microM for [3H]oleate. LY171883 binding was inhibited by LY189585, clofibric acid, ciprofibrate and bezafibrate. These findings demonstrate that peroxisome proliferators, presumably due to their structural similarity to fatty acids, are able to bind to FABP and displace an endogenous ligand from its binding site. Interaction of peroxisome proliferators with FABP may be involved in perturbations of fatty acid metabolism caused by these agents as well as in the development of the pleiotropic response of peroxisome proliferation.

Mitochondrial Fatty Acid Binding Protein Content is not Altered in Human Skeletal Muscle during Prolonged Aerobic Exercise

2006 ◽  
Vol 38 (Supplement) ◽  
pp. S543 ◽  
Author(s):  
Lawrence L. Spriet ◽  
Graham P. Holloway ◽  
George J.F. Heigenhauser ◽  
Jorge Calles-Escandon ◽  
Arend Bonen
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acid ◽  
Aerobic Exercise ◽  
Protein Content ◽  
Human Skeletal Muscle ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein ◽  
Mitochondrial Fatty Acid

A role for fatty acids and liver fatty acid binding protein in peroxisome proliferation?

1992 ◽  
Vol 20 (4) ◽  
pp. 824-827 ◽  
Author(s):  
Isabelle Issemann ◽  
Rebecca Prince ◽  
Jonathan Tugwood ◽  
Stephen Green
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Peroxisome Proliferation ◽  
Liver Fatty Acid ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Modulation of fatty-acid-binding protein content of rat heart and skeletal muscle by endurance training and testosterone treatment

1992 ◽  
Vol 421 (2-3) ◽  
pp. 274-279 ◽  
Author(s):  
Eric van Breda ◽  
Hans A. Keizer ◽  
Michaël M. Vork ◽  
Don A. M. Surtel ◽  
Yvonne F. de Jong ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Fatty Acid ◽  
Protein Content ◽  
Endurance Training ◽  
Rat Heart ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Testosterone Treatment ◽  
Acid Binding Protein

Verminderte Adipocyte fatty acid binding protein (AFABP)-Spiegel bei Patienten mit chronischer Pankreatitis

2011 ◽  
Vol 49 (08) ◽  
Author(s):  
L Selig ◽  
T Ebert ◽  
M Reiche ◽  
D Krehl ◽  
U Lossner ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Fatty Acid Binding ◽  
Acid Binding Protein
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