Regulation and Role of Myocardial Collagen Matrix Remodeling in Hypertensive Heart Disease

1997 ◽  
pp. 35-44 ◽  
Author(s):  
Reinhard C. Funck ◽  
Andreas Wilke ◽  
Heinz Rupp ◽  
Christian G. Brilla
Keyword(s):  
Heart Disease ◽  
Hypertensive Heart Disease ◽  
Collagen Matrix ◽  
Matrix Remodeling ◽  
Myocardial Collagen

The Role of Myocardial Collagen Network in Hypertensive Heart Disease

2007 ◽  
Vol 3 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Javier Diez ◽  
Begona Lopez ◽  
Arantxa Gonzalez ◽  
Ramon Querejeta
Keyword(s):  
Heart Disease ◽  
Hypertensive Heart Disease ◽  
Collagen Network ◽  
Myocardial Collagen

scholarly journals 191 Role of mir-214 in angiotensin ii induced hypertensive heart disease

Heart ◽  
2017 ◽  
Vol 103 (Suppl 5) ◽  
pp. A130.2-A131
Author(s):  
Eilidh McGinnigle ◽  
Ryszard Nosalski ◽  
Dominik Skiba ◽  
Laura Denby ◽  
Delyth Graham ◽  
...  
Keyword(s):  
Heart Disease ◽  
Angiotensin Ii ◽  
Hypertensive Heart Disease

The Role of Exercise and Physical Activity in the Prevention of Hypertensive Heart Disease

2016 ◽  
pp. 181-199
Author(s):  
Peter Kokkinos ◽  
Puneet Narayan ◽  
Andreas Pittaras ◽  
Charles Faselis
Keyword(s):  
Physical Activity ◽  
Heart Disease ◽  
Hypertensive Heart Disease

Abstract 083: Macrophages Dictate the Progression and Manifestation of Hypertensive Heart Disease in Rat

2013 ◽  
Vol 113 (suppl_1) ◽  
Author(s):  
DAVID KAIN ◽  
Chana Yagil ◽  
Natalie Landa-Rouben ◽  
Yoram Yagil ◽  
Jonathan Leor
Keyword(s):  
Heart Disease ◽  
Significant Role ◽  
Hypertensive Heart Disease ◽  
Treated Group ◽  
Anterior Wall ◽  
Wall Thickening ◽  
Macrophage Depletion ◽  
Strain And Strain Rate ◽  
Lv Remodeling

Introduction: Inflammation has been implicated in the initiation, progression and manifestation of hypertension. However, the role of macrophages in hypertension-induced LV remodeling has yet to be determined. Hypothesis: We assessed the hypothesis that macrophages play a significant role in the initiation and progression of hypertension-induced LV remodeling. Methods and Results: Hypertension was induced in male Sabra salt-sensitive (SBH/y) rats with high salt diet (8%NaCl) over 6 weeks. Hypertensive SBH/y developed LV hypertrophy, hyper-contractility and a higher LV ejection fraction (EF). Notably, the number of macrophages, particularly cardiac macrophages was significantly greater in hypertensive SBH/y than in controls. Macrophage depletion was induced after induction of hypertension by intravenous administration of clodronate liposomes at 3-day intervals over 4 weeks (n=9) and was validated by FACS analysis and ED1 (CD68) staining of heart sections. Control hypertensive rats (n=9) were treated with PBS liposomes. Surprisingly, macrophage depletion attenuate the progression of hypertension in the clodronate-treated group (from 177±2 to 179±2 mmHg) compared with controls (from 179±2 to 184 ± 5mmHg; p=0.01).Serial echocardiography studies before and 30 days after initiation of macrophage depletion or control showed that LV systolic diameter and volume were smaller; anterior wall thickening, fractional shortening and EF were higher in the macrophage-depletion group (p<0.05). LV strain and strain rate were significantly higher in the macrophage depletion group (p=0.04). Furthermore, 1 month after BP elevation, the expression of miR-31, which has been implicated in the pathogenesis of cardiac hypertrophy, was decreased (4.6-fold) in the macrophage-depleted hearts compared to controls, suggesting that macrophages control miR-31 expression in LV hypertrophy. Conclusion: Our findings suggest a significant role of macrophages in the initiation and progression of salt-sensitive hypertension and the related heart disease. Targeting macrophages, therefore, could be a potential therapeutic target for the treatment of hypertension and prevention of LV remodeling and dysfunction.

scholarly journals The role of fibroblast – Cardiomyocyte interaction for atrial dysfunction in HFpEF and hypertensive heart disease

2019 ◽  
Vol 131 ◽  
pp. 53-65 ◽  
Author(s):  
David Bode ◽  
Diana Lindner ◽  
Michael Schwarzl ◽  
Dirk Westermann ◽  
Peter Deissler ◽  
...  
Keyword(s):  
Heart Disease ◽  
Hypertensive Heart Disease
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