Diagnosis of defects in oxidative muscle metabolism by non-invasive tissue oximetry

1997 ◽  
pp. 7-10 ◽  
Author(s):  
William Bank ◽  
Britton Chance
Keyword(s):  
Muscle Metabolism ◽  
Non Invasive ◽  
Tissue Oximetry

scholarly journals Exploring personalized postoperative non-invasive tissue oximetry in DIEP flap breast reconstruction

2021 ◽  
Author(s):  
Anouk A. M. A. Lindelauf ◽  
Nousjka P. A. Vranken ◽  
Rutger M. Schols ◽  
Esther A. C. Bouman ◽  
Patrick W. Weerwind ◽  
...  
Keyword(s):  
Early Detection ◽  
Breast Reconstruction ◽  
Near Infrared ◽  
Diep Flap ◽  
Baseline Measurement ◽  
Flap Surgery ◽  
Level Of Evidence ◽  
Non Invasive ◽  
Vascular Compromise ◽  
Tissue Oximetry

Abstract Early detection of vascular compromise after autologous breast reconstruction is crucial to enable timely re-exploration for flap salvage. Several studies proposed non-invasive tissue oximetry for early identification of ischemia of deep inferior epigastric perforator (DIEP) flaps. The present study aimed to explore the utility of non-invasive tissue oximetry following DIEP flap surgery using a personalized oxygenation threshold. Methods Patients undergoing immediate/delayed DIEP flap surgery were included in this prospective observational study. DIEP flap tissue oxygenation (StO2) was monitored continuously using near-infrared spectroscopy. A baseline measurement was performed by positioning one sensor at the marked position of the major inferior epigastric perforator on the abdomen. A new sensor was positioned postoperatively on the transplanted tissue. In unilateral procedures, postoperative StO2 values of the native breast were also obtained. Measurements were continued for 24 h. Results Thirty patients (42 flaps) were included. Fourteen patients (46.7%) had an uncomplicated postoperative course. A minor complication was observed in thirteen patients; in five patients, at least one major complication occurred, requiring re-exploration. Median StO2 readings were significantly lower in patients with major complications compared to uncomplicated cases. In fourteen unilateral DIEP flap procedures, StO2 values of the native breast were similar to the preoperative baseline measurement (92%; p = 0.452). Conclusions Non-invasive tissue oximetry following DIEP flap surgery could aid in early detection of vascular compromise. StO2 values of the native breast and abdominal wall preoperatively can be used interchangeably and can serve as personalized reference value. Level of evidence: Level IV, diagnostic / prognostic study.

Technetium-99m sestamibi leg scintigraphy for non-invasive assessment of propionyl- l -carnitine induced changes in skeletal muscle metabolism

1997 ◽  
Vol 24 (7) ◽  
pp. 762-766
Author(s):  
Corrado Cittanti ◽  
Paolo Colamussi ◽  
Melchiore Giganti ◽  
Cesare Orlandi ◽  
Licia Uccelli ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Metabolism ◽  
Technetium 99M Sestamibi ◽  
Skeletal Muscle Metabolism ◽  
Technetium 99M ◽  
Non Invasive ◽  
Induced Changes

scholarly journals Non-invasive tissue oximetry

2017 ◽  
Author(s):  
Vranken
Keyword(s):  
Non Invasive ◽  
Tissue Oximetry

Einfluß von Hyperund Hypothyreose auf den Energiestoffwechsel der Skelettmuskulatur

1991 ◽  
Vol 30 (03) ◽  
pp. 77-83 ◽  
Author(s):  
D. Moka ◽  
P. Theissen ◽  
A. Linden ◽  
W. Waters ◽  
H. Schicha
Keyword(s):  
Quantitative Measurement ◽  
Evaluation Method ◽  
Muscle Metabolism ◽  
Resonance Spectroscopy ◽  
Clinical Value ◽  
Non Invasive ◽  
External Standard ◽  
Hypothyroid Patients ◽  
Invasive Evaluation ◽  
Similar Decrease

31P magnetic resonance spectroscopy allows non-invasive evaluation of phosphorus metabolism in man. The purpose of the present study was to assess the influence of hyper- and hypothyroidism on the metabolism of resting human skeletal muscle. The present data show that quantitative measurement of phosphate metabolism by NMR is possible as also demonstrated by other studies. Using a quantitative evaluation method with an external standard, significant differences in the levels of phosphocreatine, adenosintriphosphate, and phosphodiesters were found. In hypothyroid patients a TSH-dependent increase in phosphodiesters and a decrease in adenosintriphosphate and phosphocreatine was observed. In hyperthyroidism a similar decrease in adenosintriphosphate but a considerably higher decrease in phosphocreatine occurred. In the light of the results of other studies of muscle metabolism, these changes appear to be non-specific so that further studies are required to assess the clinical value of such measurements.

What is MR spectroscopy?

2017 ◽  
Vol 103 (4) ◽  
pp. 213-216 ◽  
Author(s):  
Karen Angela Manias ◽  
Andrew Peet
Keyword(s):  
Brain Tumours ◽  
Metabolic Diseases ◽  
Muscle Metabolism ◽  
Improve Patient Care ◽  
Added Value ◽  
Resonance Spectroscopy ◽  
Routine Practice ◽  
Non Invasive ◽  
Clinical Scenarios ◽  
Disease And Disorders

1H-Magnetic Resonance Spectroscopy (MRS) is a novel advanced imaging technique used as an adjunct to MRI to reveal complementary non-invasive information about the biochemical composition of imaged tissue. Clinical uses in paediatrics include aiding diagnosis of brain tumours, neonatal disorders such as hypoxic-ischaemic encephalopathy, inherited metabolic diseases, traumatic brain injury, demyelinating conditions and infectious brain lesions. MRS has potential to improve diagnosis and treatment monitoring of childhood brain tumours and other CNS diseases, facilitate biopsy and surgical planning, and provide prognostic biomarkers. MRS is employed as a research tool outside the brain in liver disease and disorders of muscle metabolism. The range of clinical uses is likely to increase with growing evidence for added value. Multicentre trials are needed to definitively establish the benefits of MRS in specific clinical scenarios and integrate this promising new technique into routine practice to improve patient care. This article gives a brief overview of MRS and its potential clinical applications, and addresses challenges surrounding translation into practice.

scholarly journals Oxidative metabolism in muscle

1997 ◽  
Vol 352 (1354) ◽  
pp. 677-683 ◽  
Author(s):  
M. Ferrari ◽  
T. Binzoni ◽  
V. Quaresima
Keyword(s):  
Skeletal Muscle ◽  
Infrared Spectroscopy ◽  
Near Infrared Spectroscopy ◽  
Oxidative Metabolism ◽  
Skeletal Muscles ◽  
Near Infrared ◽  
Clinical Medicine ◽  
Muscle Metabolism ◽  
Non Invasive ◽  
Invasive Measurement

Oxidative metabolism is the dominant source of energy for skeletal muscle. Near–infrared spectroscopy allows the non–invasive measurement of local oxygenation, blood flow and oxygen consumption. Although several muscle studies have been made using various near–infrared optical techniques, it is still difficult to interpret the local muscle metabolism properly. The main findings of near–infrared spectroscopy muscle studies in human physiology and clinical medicine are summarized. The advantages and problems of near–infrared spectroscopy measurements, in resting and exercising skeletal muscles studies, are discussed through some representative examples.

scholarly journals Laser fluorescence spectroscopy and optical tissue oximetry in the diagnosis of skin fibrosis

2019 ◽  
Vol 8 (1) ◽  
pp. 38-45 ◽  
Author(s):  
Yu. V. Chursinova ◽  
D. A. Kulikov ◽  
D. A. Rogatkin ◽  
I. A. Raznitsyna ◽  
D. V. Mosalskaya ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Fluorescence Spectroscopy ◽  
Laser Fluorescence ◽  
Non Invasive ◽  
Clinical Biomarkers ◽  
Wide Range ◽  
Endogenous Fluorescence ◽  
Modern Medical Practice ◽  
Tissue Oximetry ◽  
Laser Fluorescence Spectroscopy

There are currently no effective measures to combat fibrosis in modern medical practice. One of the reasons for that is the late diagnosis associated with the lack of available clinical biomarkers and effective methods of non-invasive detection of the process. Fibrosis of the skin is characterized by fibrosis of the dermis, underlying tissues and is represented by a wide range of nosologies. Scleroderma and scars are of the greatest interest for the study. Skin changes in the development of bleomycin-induced fibrosis was studied in the experimental model using laser fluorescence spectroscopy and optical tissue oximetry. A significant increase in the rates of endogenous fluorescence of porphyrins, caused by inflammation and hypoxia, was detected at 7 and 21 days. An increased intensity of endogenous collagen fluorescence and a decreased specific oxygen uptake due to excess accumulation of the extracellular matrix were recorded on the 21st day after bleomycin treatment. Synchronous measurements of the collagen fluorescence and the specific oxygen uptake allowed to correlate the obtained data and the phases of the fibrogenic response described morphologically. The results allow to judge the severity of inflammation and hypoxia in the process of the fibrosis development. The objective and quantitative nature of the recorded parameters makes it possible to develop criteria for diagnosing the phases of fibrosis development.

Technetium-99m sestamibi leg scintigraphy for non-invasive assessment of propionyl-l-carnitine induced changes in skeletal muscle metabolism

1997 ◽  
Vol 24 (7) ◽  
pp. 762-766 ◽  
Author(s):  
Corrado Cittanti ◽  
Paolo Colamussi ◽  
Melchiore Giganti ◽  
Cesare Orlandi ◽  
Licia Uccelli ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Metabolism ◽  
Technetium 99M Sestamibi ◽  
Skeletal Muscle Metabolism ◽  
Technetium 99M ◽  
Non Invasive ◽  
Induced Changes

scholarly journals Non-invasive tissue oximetry following unilateral DIEP-flap reconstruction: A pilot evaluation

JPRAS Open ◽  
2017 ◽  
Vol 12 ◽  
pp. 59-65 ◽  
Author(s):  
N.P.A. Vranken ◽  
P.W. Weerwind ◽  
M.A. van Onna ◽  
E.A.C. Bouman ◽  
R.R.W.J. van der Hulst
Keyword(s):  
Diep Flap ◽  
Flap Reconstruction ◽  
Non Invasive ◽  
Tissue Oximetry
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