Immunopathology of Malignant Disease in Experimental Animals Virus-Induced Tumors

A Possible Immune Reaction Producing Spontaneous Remission in Leukemia

Blood ◽

10.1182/blood.v25.4.541.541 ◽

1965 ◽

Vol 25 (4) ◽

pp. 541-547 ◽

Cited By ~ 10

Author(s):

LUTHER L. BURKETT ◽

MURRAY L. FIELDS ◽

LEMUEL W. DIGGS

Keyword(s):

Multiple Myeloma ◽

Bone Marrow ◽

Malignant Disease ◽

Plasma Cells ◽

Immune Reaction ◽

Spontaneous Remission ◽

Bence Jones Protein ◽

Tumor Inhibition ◽

Abnormal Protein ◽

Experimental Animals

Abstract A patient is described in whom four phases of illness were recognized: (1) erythroleukemia, (2) brisk bone marrow plasmocytosis with Bence Jones protein in the urine suggesting multiple myeloma, (3) normality physically and of blood and bone marrow, with the exception of slight splenomegaly, (4) myeloblastic leukemia with death from Pseudomonas septicemia. Local and reticuloendothelial plasmocytic reactions have been observed in experimental animals and in man with malignant disease, and this occurrence has been related to tumor inhibition and improved prognosis. Paraproteinemia and paraproteinuria have been noted in malignancies other than those arising from plasma cells or lymphocytes. It is suggested that the plasmocytosis and abnormal protein in the case reported, as well as in other similar cases previously reported, may have represented an immune reaction induced by the malignancy and responsible for its remission.

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Analytical Electron Microscopy (AEM) of Meningeal Cells Exposed to Particulate Cobalt During Studies of Experimental Epilepsy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100053590 ◽

1982 ◽

Vol 40 ◽

pp. 186-187

Author(s):

R.G. Frederickson ◽

R.G. Ulrich ◽

J.L. Culberson

Keyword(s):

Electron Microscopy ◽

Analytical Electron Microscopy ◽

Experimental Epilepsy ◽

Metallic Cobalt ◽

Experimental Animals ◽

X Ray ◽

Brain Surface ◽

Meningeal Cells ◽

Analytical Electron ◽

The Brain

Metallic cobalt acts as an epileptogenic agent when placed on the brain surface of some experimental animals. The mechanism by which this substance produces abnormal neuronal discharge is unknown. One potentially useful approach to this problem is to study the cellular and extracellular distribution of elemental cobalt in the meninges and adjacent cerebral cortex. Since it is possible to demonstrate the morphological localization and distribution of heavy metals, such as cobalt, by correlative x-ray analysis and electron microscopy (i.e., by AEM), we are using AEM to locate and identify elemental cobalt in phagocytic meningeal cells of young 80-day postnatal opossums following a subdural injection of cobalt particles.

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Oncogenesis and the Lucké Virus

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100100743 ◽

1968 ◽

Vol 26 ◽

pp. 200-201

Author(s):

A. E. Vatter ◽

J. Zambernard

Keyword(s):

Rna Viruses ◽

Vegetative State ◽

Temperature Sensitive ◽

Structural Level ◽

Oncogenic Viruses ◽

Dna Viruses ◽

Leopard Frogs ◽

Renal Adenocarcinoma ◽

Induced Tumors ◽

Northern Leopard Frogs

Oncogenic viruses, like viruses in general, can be divided into two classes, those that contain deoxyribonucleic acid (DNA) and those that contain ribonucleic acid (RNA). The RNA viruses have been recovered readily from the tumors which they cause whereas, the DNA-virus induced tumors have not yielded the virus. Since DNA viruses cannot be recovered, the bulk of present day investigations have been concerned with RNA viruses.The Lucké renal adenocarcinoma is a spontaneous tumor which occurs in northern leopard frogs (Rana pipiens) and has received increased attention in recent years because of its probable viral etiology. This hypothesis was first advanced by Lucké after he observed intranuclear inclusions in some of the tumor cells. Tumors with inclusions were examined at the fine structural level by Fawcett who showed that they contained immature and mature virus˗like particles.The use of this system in the study of oncogenic tumors offers several unique features, the virus has been shown to contain DNA and it can be recovered from the tumor, also, it is temperature sensitive. This latter feature is of importance because the virus can be transformed from a latent to a vegetative state by lowering or elevating the environmental temperature.

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Ultrastructure and analytical microprobe analysis of simian lung mite pigments

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100143249 ◽

1986 ◽

Vol 44 ◽

pp. 324-325

Author(s):

R. W. Cole ◽

J. C. Kim

Keyword(s):

Biomedical Research ◽

Tissue Damage ◽

Microprobe Analysis ◽

Old World Monkeys ◽

Old World ◽

Experimental Animals ◽

The Past ◽

Lung Mite ◽

Mite Infestations ◽

Cardiopulmonary System

In recent years, non-human primates have become indispensable as experimental animals in many fields of biomedical research. Pharmaceutical and related industries alone use about 2000,000 primates a year. Respiratory mite infestations in lungs of old world monkeys are of particular concern because the resulting tissue damage can directly effect experimental results, especially in those studies involving the cardiopulmonary system. There has been increasing documentation of primate parasitology in the past twenty years.

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