Effects of Lipid Lowering Diets and of Bile Acid Sequestrants on Plasma Lipoproteins and Biliary Metabolism

1985 ◽  
pp. 101-112
Author(s):  
Cesare R. Sirtori
Keyword(s):  
Bile Acid ◽  
Plasma Lipoproteins ◽  
Lipid Lowering ◽  
Bile Acid Sequestrants

scholarly journals Oral Lipid-Lowering Treatments Beyond Statins: Too Old and Outdated or Still Useful?

2021 ◽  
Vol 23 (12) ◽  
Author(s):  
Klaus G. Parhofer
Keyword(s):  
Bile Acid ◽  
Ldl Cholesterol ◽  
Treatment Algorithm ◽  
New Drugs ◽  
Lipid Lowering ◽  
Oral Drugs ◽  
Bile Acid Sequestrants ◽  
Risk Patients ◽  
Statin Drugs

Abstract Purpose of Review For many years, the lipid-lowering armamentarium consisted of statins and/or ezetimibe and/or bile acid sequestrants and/or fibrates. Now, with the availability of new drugs mostly injectables, the field has changed and the role of oral non-statin drugs (including bempedoic acid) must be reevaluated. Recent Findings Ezetimibe remains a very important combination partner for statins with continuously increasing treatment numbers. Bempedoic acid is another interesting combination partner for statin/ezetimibe or ezetimibe alone but lacks in contrast to ezetimibe evidence from outcome trials. The role of fibrates is less clear as they have shown disappointing results in outcome trials but may still be used in selected, high-risk patients with combined dyslipidemia. Bile acid sequestrants are now rarely used as there are stronger, better tolerable ways to lower LDL-cholesterol. Summary With the introduction of new injectable lipid-lowering drugs, some oral drugs such as ezetimibe and bempedoic acid still have an important spot in our treatment algorithm others such as fibrates have a less clear role while again others are now rarely used.

scholarly journals Role of Bile Acids in the Regulation of Food Intake, and Their Dysregulation in Metabolic Disease

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1104
Author(s):  
Cong Xie ◽  
Weikun Huang ◽  
Richard L. Young ◽  
Karen L. Jones ◽  
Michael Horowitz ◽  
...  
Keyword(s):  
Bile Acid ◽  
Bile Acids ◽  
Peptide Yy ◽  
Glycogen Synthesis ◽  
Hormone Secretion ◽  
Gastrointestinal Hormones ◽  
Farnesoid X Receptor ◽  
Gastrointestinal Hormone ◽  
Bile Acid Sequestrants

Bile acids are cholesterol-derived metabolites with a well-established role in the digestion and absorption of dietary fat. More recently, the discovery of bile acids as natural ligands for the nuclear farnesoid X receptor (FXR) and membrane Takeda G-protein-coupled receptor 5 (TGR5), and the recognition of the effects of FXR and TGR5 signaling have led to a paradigm shift in knowledge regarding bile acid physiology and metabolic health. Bile acids are now recognized as signaling molecules that orchestrate blood glucose, lipid and energy metabolism. Changes in FXR and/or TGR5 signaling modulates the secretion of gastrointestinal hormones including glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), hepatic gluconeogenesis, glycogen synthesis, energy expenditure, and the composition of the gut microbiome. These effects may contribute to the metabolic benefits of bile acid sequestrants, metformin, and bariatric surgery. This review focuses on the role of bile acids in energy intake and body weight, particularly their effects on gastrointestinal hormone secretion, the changes in obesity and T2D, and their potential relevance to the management of metabolic disorders.

Effects of pomegranate peel polyphenols on lipid accumulation and cholesterol metabolic transformation in L-02 human hepatic cells via the PPARγ-ABCA1/CYP7A1 pathway

2016 ◽  
Vol 7 (12) ◽  
pp. 4976-4983 ◽  
Author(s):  
Ou Lv ◽  
Lifang Wang ◽  
Jianke Li ◽  
Qianqian Ma ◽  
Wei Zhao
Keyword(s):  
Bile Acid ◽  
Lipid Accumulation ◽  
Cell Model ◽  
Hepatic Cell ◽  
Total Bile Acid ◽  
Lipid Lowering ◽  
Pomegranate Peel ◽  
Hepatic Cells ◽  
Metabolic Transformation ◽  
Lipid Lowering Effect

PPPs, PC and PEA in different concentrations were found to decrease the total cholesterol (TC) content and increase the total bile acid (TBA) content of a human hepatic cell model, and so possess a lipid-lowering effect.

scholarly journals ВЛИЯНИЕ ВЕЩЕСТВА НА ОСНОВЕ ФИБРОИНА ШЕЛКА НА ПОКАЗАТЕЛИ ЛИПИДНОГО ОБМЕНА У КРЫС С ЭКСПЕРИМЕНТАЛЬНОЙ ГИПЕРХОЛЕСТЕРИНЕМИЕЙ

World Science ◽  
2018 ◽  
Vol 1 (10(38)) ◽  
pp. 38-42
Author(s):  
Нишантаев М. К. ◽  
Арифджанов С. З. ◽  
Айходжаев Б. К. ◽  
Юлдашев Н. М.
Keyword(s):  
Lipid Metabolism ◽  
Bile Acid ◽  
Polymer Physics ◽  
The Body ◽  
Hypocholesterolemic Effect ◽  
Bile Acid Sequestrants ◽  
Experimental Hypercholesterolemia ◽  
The Republic ◽  
Academy Of Sciences ◽  
Disorders Of Lipid Metabolism

The article presents the results of a study on the effectiveness of a substance based on silk fibroin, obtained at the Institute of Chemistry and Polymer Physics of the Academy of Sciences of the Republic of Uzbekistan, in eliminating disorders of lipid metabolism in the body. In experiments in rats with experimental hypercholesterolemia, the substance was found to have a cholesterol-lowering property, which is manifested by a decrease in cholesterol level both in blood and in tissues. Studies on the mechanism of the hypocholesterolemic effect of the studied substance have shown its effects on the enterohepatic pathway of bile acids, which makes it possible to classify this substance as a group of bile acid sequestrants.

Images in cardiovascular medicine: xanthomas triggered by bile acid sequestrants

2008 ◽  
Vol 2 (1) ◽  
pp. 58-59 ◽  
Author(s):  
Robert D. Brook ◽  
Robert L. Bard ◽  
Melvyn Rubenfire
Keyword(s):  
Bile Acid ◽  
Cardiovascular Medicine ◽  
Bile Acid Sequestrants

Surface-functionalized layered double hydroxide nanocontainers as bile acid sequestrants for lowering hyperlipidemia

2020 ◽  
Vol 590 ◽  
pp. 119921
Author(s):  
Chiao-Wen Lin ◽  
Shi-Xiang Lin ◽  
Ranjith Kumar Kankala ◽  
Prabhakar Busa ◽  
Jin-Pei Deng ◽  
...  
Keyword(s):  
Bile Acid ◽  
Layered Double Hydroxide ◽  
Bile Acid Sequestrants ◽  
Double Hydroxide
Sign in / Sign up

Export Citation Format

Share Document