scholarly journals ВЛИЯНИЕ ВЕЩЕСТВА НА ОСНОВЕ ФИБРОИНА ШЕЛКА НА ПОКАЗАТЕЛИ ЛИПИДНОГО ОБМЕНА У КРЫС С ЭКСПЕРИМЕНТАЛЬНОЙ ГИПЕРХОЛЕСТЕРИНЕМИЕЙ

World Science ◽  
2018 ◽  
Vol 1 (10(38)) ◽  
pp. 38-42
Author(s):  
Нишантаев М. К. ◽  
Арифджанов С. З. ◽  
Айходжаев Б. К. ◽  
Юлдашев Н. М.

The article presents the results of a study on the effectiveness of a substance based on silk fibroin, obtained at the Institute of Chemistry and Polymer Physics of the Academy of Sciences of the Republic of Uzbekistan, in eliminating disorders of lipid metabolism in the body. In experiments in rats with experimental hypercholesterolemia, the substance was found to have a cholesterol-lowering property, which is manifested by a decrease in cholesterol level both in blood and in tissues. Studies on the mechanism of the hypocholesterolemic effect of the studied substance have shown its effects on the enterohepatic pathway of bile acids, which makes it possible to classify this substance as a group of bile acid sequestrants.

2021 ◽  
Vol 12 (1) ◽  
pp. 14-18
Author(s):  
V. Macari ◽  
N. Pavlicenco ◽  
A. Rotaru ◽  
A. Pirlog

At present, the positive effect of BioR remedy obtained by original technologies from the biomass of cyanobacterium Spirulina platensis was demonstrated at the Academy of Sciences of the Republic of Moldova on pigs, rabbits and broilers. Considering the fact that remedies of vegetal origin are not harmful to animals, people and environment, they are of particular interest to the most developed branch of animal husbandry – the aviculture, including for the production and exploitation of quail. Until present, studies on the action of the nominated preparation on the physiological-metabolic status, including lipid metabolism in quail for reconditioning have not been conducted. The biological material was 150 quail at the end of the laying cycle divided into 3 batches of 50 birds. The tested preparation was administered intramuscularly to the quails two times consecutively at the onset of the study and secondly at 14 days after the first administration at a dose of 0,5 ml /head. In another experimental batch, the commercial product Butofan was administered in order to compare the obtained results. Birds of the control group received 0,5 ml of solution of NaCl of 0,9 % in both terms. The birds included in the study were analogous in terms of race, age, body weight and physiological status. During all time of the study, quails were monitored: clinical parameters, body weight, and number of eggs. In addition, for laboratory investigations, blood was collected from five quails at the start of the study before the tested preparations were administered and then 2 times during the study. It has been established that the tested remedies do not cause adverse reactions or deviations in quails' health. Moreover, BioR showed adaptive properties, reflected in body temperature lower by 0,32 C than the control group and 0,18 C than the group treated with Butofan. Similar manifestations were also found in birds' breathing. Biochemical researches performed on quails that have benefited from the BioR remedy reveal a true decrease in total lipids in one investigation and an increase in triglycerides at this stage and their decrease at the end of the study. Additionally, both BioR and Butofan remedies induced an increase in the blood serum of ß-lipoproteins at both stages of research, while cholesterol values did not show any essential changes. In conclusion, we can state that the BioR product has a beneficial effect on quail, including their lipid metabolism.


2004 ◽  
Vol 50 (3) ◽  
pp. 48-52
Author(s):  
Yu. P. Sych ◽  
V. V. Fadeev ◽  
G. A. Mel'nichenko ◽  
A. L. Syrkin ◽  
A. P. Roitman

Subclinical hypothyroidism (SG) is a syndrome caused by a persistent borderline decrease in the level of thyroid hormones in the body, in which a normal level of T4 is determined in combination with a moderately elevated level of TSH. SG is the most common thyroid dysfunction.


2020 ◽  
Vol 9 (4) ◽  
pp. 40-43
Author(s):  
N. K. Yuldasheva ◽  
S. D. Gusakova ◽  
D. Kh. Nurullaeva ◽  
N. T. Farmanova ◽  
R. P. Zakirova ◽  
...  

Introduction. Lipids are a widespread group of biologically active substances in nature, making up the bulk of the organic substances of all living organisms. They accumulate in plants in seeds, as well as in fruits and perform a number of vital functions: they are the main components of cell membranes and the energy reserve for the body.Aim. Study of neutral lipids of sown oats (Avena sativa L.).Materials and methods. The objects of the study were fruits (grains) of oats of the sown variety "Tashkent 1," harvested in the Republic of Uzbekistan. Results and discussions. Neutral lipids of oat grains have been found to contain 13 fatty acids with a predominance of the sum of oleic, linolenic and linoleic acids. The total degree of unsaturation was almost 78%. Absorption bands characteristic of these substances were observed in the IR spectrum of MEGC.Conclusion. According to the results of the NL analysis, oat grains consisted of triacylglycerides and free LCDs, which were accompanied by hydrocarbons, phytosterols, triterpenoids and tocopherols.


Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1078
Author(s):  
Debasish Roy ◽  
Andrea Tedeschi

Axons in the adult mammalian nervous system can extend over formidable distances, up to one meter or more in humans. During development, axonal and dendritic growth requires continuous addition of new membrane. Of the three major kinds of membrane lipids, phospholipids are the most abundant in all cell membranes, including neurons. Not only immature axons, but also severed axons in the adult require large amounts of lipids for axon regeneration to occur. Lipids also serve as energy storage, signaling molecules and they contribute to tissue physiology, as demonstrated by a variety of metabolic disorders in which harmful amounts of lipids accumulate in various tissues through the body. Detrimental changes in lipid metabolism and excess accumulation of lipids contribute to a lack of axon regeneration, poor neurological outcome and complications after a variety of central nervous system (CNS) trauma including brain and spinal cord injury. Recent evidence indicates that rewiring lipid metabolism can be manipulated for therapeutic gain, as it favors conditions for axon regeneration and CNS repair. Here, we review the role of lipids, lipid metabolism and ectopic lipid accumulation in axon growth, regeneration and CNS repair. In addition, we outline molecular and pharmacological strategies to fine-tune lipid composition and energy metabolism in neurons and non-neuronal cells that can be exploited to improve neurological recovery after CNS trauma and disease.


Healthcare ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 441
Author(s):  
Md. Mohaimenul Islam ◽  
Tahmina Nasrin Poly ◽  
Belal Alsinglawi ◽  
Li-Fong Lin ◽  
Shuo-Chen Chien ◽  
...  

The application of artificial intelligence (AI) to health has increased, including to COVID-19. This study aimed to provide a clear overview of COVID-19-related AI publication trends using longitudinal bibliometric analysis. A systematic literature search was conducted on the Web of Science for English language peer-reviewed articles related to AI application to COVID-19. A search strategy was developed to collect relevant articles and extracted bibliographic information (e.g., country, research area, sources, and author). VOSviewer (Leiden University) and Bibliometrix (R package) were used to visualize the co-occurrence networks of authors, sources, countries, institutions, global collaborations, citations, co-citations, and keywords. We included 729 research articles on the application of AI to COVID-19 published between 2020 and 2021. PLOS One (33/729, 4.52%), Chaos Solution Fractals (29/729, 3.97%), and Journal of Medical Internet Research (29/729, 3.97%) were the most common journals publishing these articles. The Republic of China (190/729, 26.06%), the USA (173/729, 23.73%), and India (92/729, 12.62%) were the most prolific countries of origin. The Huazhong University of Science and Technology, Wuhan University, and the Chinese Academy of Sciences were the most productive institutions. This is the first study to show a comprehensive picture of the global efforts to address COVID-19 using AI. The findings of this study also provide insights and research directions for academic researchers, policymakers, and healthcare practitioners who wish to collaborate in these domains in the future.


2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Yang Zhao ◽  
Hao Guo ◽  
Wenda Wang ◽  
Guoyang Zheng ◽  
Zhan Wang ◽  
...  

Abstract Objective Tuberous sclerosis complex (TSC) is a rare autosomal dominant disease characterized by lesions throughout the body. Our previous study showed the abnormal up-regulation of miRNAs plays an important part in the pathogenesis of TSC-related renal angiomyolipoma (TSC-RAML). circRNAs were known as important regulators of miRNA, but little is known about the circRNAs in TSC-RAMLs. Methods Microarray chips and RNA sequencing were used to identify the circRNAs and mRNAs that were differently expressed between the TSC-RAML and normal kidney tissue. A competitive endogenous RNA (ceRNA) regulatory network was constructed to reveal the regulation of miRNAs and mRNAs by the circRNAs. The biological functions of circRNA and mRNA were analyzed by pathway analysis. Microenvironmental cell types were estimated with the MCP-counter package. Results We identified 491 differentially expressed circRNAs (DECs) and 212 differentially expressed genes (DEGs), and 6 DECs were further confirmed by q-PCR. A ceRNA regulatory network which included 6 DECs, 5 miRNAs, and 63 mRNAs was established. Lipid biosynthetic process was significantly up-regulated in TSC-RAML, and the humoral immune response and the leukocyte chemotaxis pathway were found to be down-regulated. Fibroblasts are enriched in TSC-RAML, and the up-regulation of circRNA_000799 and circRNA_025332 may be significantly correlated to the infiltration of the fibroblasts. Conclusion circRNAs may regulate the lipid metabolism of TSC-RAML by regulation of the miRNAs. Fibroblasts are enriched in TSC-RAMLs, and the population of fibroblast may be related to the alteration of circRNAs of TSC-RAML. Lipid metabolism in fibroblasts is a potential treatment target for TSC-RAML.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Raphael Severino Bonadio ◽  
Larissa Barbosa Nunes ◽  
Patricia Natália S. Moretti ◽  
Juliana Forte Mazzeu ◽  
Stefano Cagnin ◽  
...  

AbstractMost biological features that occur on the body after death were already deciphered by traditional medicine. However, the molecular mechanisms triggered in the cellular microenvironment are not fully comprehended yet. Previous studies reported gene expression alterations in the post-mortem condition, but little is known about how the environment could influence RNA degradation and transcriptional regulation. In this work, we analysed the transcriptome of mouse brain after death under three concealment simulations (air exposed, buried, and submerged). Our analyses identified 2,103 genes differentially expressed in all tested groups 48 h after death. Moreover, we identified 111 commonly upregulated and 497 commonly downregulated genes in mice from the concealment simulations. The gene functions shared by the individuals from the tested environments were associated with RNA homeostasis, inflammation, developmental processes, cell communication, cell proliferation, and lipid metabolism. Regarding the altered biological processes, we identified that the macroautophagy process was enriched in the upregulated genes and lipid metabolism was enriched in the downregulated genes. On the other hand, we also described a list of biomarkers associated with the submerged and buried groups, indicating that these environments can influence the post-mortem RNA abundance in its particular way.


2021 ◽  
pp. 2001068
Author(s):  
Chloé Robert ◽  
Charline Buisson ◽  
Fabienne Laugerette ◽  
Hélène Abrous ◽  
Dominique Rainteau ◽  
...  

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1104
Author(s):  
Cong Xie ◽  
Weikun Huang ◽  
Richard L. Young ◽  
Karen L. Jones ◽  
Michael Horowitz ◽  
...  

Bile acids are cholesterol-derived metabolites with a well-established role in the digestion and absorption of dietary fat. More recently, the discovery of bile acids as natural ligands for the nuclear farnesoid X receptor (FXR) and membrane Takeda G-protein-coupled receptor 5 (TGR5), and the recognition of the effects of FXR and TGR5 signaling have led to a paradigm shift in knowledge regarding bile acid physiology and metabolic health. Bile acids are now recognized as signaling molecules that orchestrate blood glucose, lipid and energy metabolism. Changes in FXR and/or TGR5 signaling modulates the secretion of gastrointestinal hormones including glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), hepatic gluconeogenesis, glycogen synthesis, energy expenditure, and the composition of the gut microbiome. These effects may contribute to the metabolic benefits of bile acid sequestrants, metformin, and bariatric surgery. This review focuses on the role of bile acids in energy intake and body weight, particularly their effects on gastrointestinal hormone secretion, the changes in obesity and T2D, and their potential relevance to the management of metabolic disorders.


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