Free Radical Mechanism of Oxidative Modification of Low Density Lipoprotein (or the Rancidity of Body Fat)

1995 ◽  
pp. 96-116 ◽  
Author(s):  
Balaraman Kalyanaraman
Keyword(s):  
Free Radical ◽  
Body Fat ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Oxidative Modification ◽  
Radical Mechanism ◽  
Low Density ◽  
Free Radical Mechanism

Antioxidants and atherosclerosis

2004 ◽  
Vol 32 (1) ◽  
pp. 156-159 ◽  
Author(s):  
E. Niki
Keyword(s):  
Free Radical ◽  
Vitamin E ◽  
Low Density Lipoprotein ◽  
Radical Scavenging ◽  
Density Lipoprotein ◽  
Active Species ◽  
Oxidative Modification ◽  
Ldl Oxidation ◽  
Low Density ◽  
Mediated Oxidation

The oxidative modification of low-density lipoprotein (LDL) can be induced by various active species by different mechanisms. Vitamin E and other radical-scavenging antioxidants can inhibit the free radical-mediated oxidation of LDL, but they are not effective against LDL oxidation induced by non-radical mechanisms.

Oxidative modification of triacylglycerol-rich lipoproteins

2003 ◽  
Vol 31 (5) ◽  
pp. 1062-1065 ◽  
Author(s):  
I.S. Young ◽  
C. McFarlane ◽  
J. McEneny
Keyword(s):  
Particle Size ◽  
Fatty Acid Composition ◽  
Arterial Wall ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Oxidative Modification ◽  
Low Density ◽  
Lipoprotein Oxidation ◽  
Oxidative Reactions ◽  
Mediated Oxidation

Lipoprotein oxidation is thought to play a pivotal role in the evolution of atherosclerosis. Low-density lipoprotein (LDL) is the main source of oxidized lipid in the arterial wall. Oxidation of LDL alters its properties in a number of ways, making it more atherogenic, but oxidation of other lipoprotein classes may also be important. Common mechanisms are likely to contribute to the oxidation of all lipoprotein classes, with enzyme-mediated oxidation likely to be most important. Antioxidant content, fatty acid composition, particle size and the presence of seeding hydroperoxides also influence oxidative reactions. Larger triglyceride-rich lipoproteins are less likely to enter the arterial wall than LDL, but when oxidized will deliver a greater oxidant load to the arterial wall.

Sign in / Sign up

Export Citation Format

Share Document