Longitudinal Studies of the Effects of Oral Contraceptive Therapy on Plasma Glucose, Non-Esterified Fatty Acid, Insulin and Blood Pyruvate Levels During Oral and Intravenous Glucose Tolerance Tests

1969 ◽  
pp. 157-177 ◽  
Author(s):  
V. Wynn ◽  
J. W. H. Doar
Keyword(s):  
Fatty Acid ◽  
Oral Contraceptive ◽  
Glucose Tolerance ◽  
Longitudinal Studies ◽  
Plasma Glucose ◽  
Intravenous Glucose ◽  
Contraceptive Therapy ◽  
Glucose Tolerance Tests ◽  
Intravenous Glucose Tolerance Tests ◽  
Oral Contraceptive Therapy

Low Vitamin K Intake Effects on Glucose Tolerance in Rats

1999 ◽  
Vol 69 (1) ◽  
pp. 27-31 ◽  
Author(s):  
Sakamoto ◽  
Wakabayashi ◽  
Sakamoto
Keyword(s):  
Glucose Tolerance ◽  
Vitamin K ◽  
Plasma Glucose ◽  
Insulin Response ◽  
Glucose Load ◽  
Intravenous Glucose ◽  
Intravenous Glucose Tolerance ◽  
Glucose Tolerance Tests ◽  
Early Insulin Response ◽  
Intravenous Glucose Tolerance Tests

To investigate the effects of vitamin K (VK) on pancreatic function, intravenous glucose tolerance tests were performed in rats fed with and without low VK diet (inclucing less than 20% required vitamin K1). Plasma glucose and immuno-reactive insulin (IRI) were determined. It was found that at 0 min., plasma glucose and IRI levels in low VK group were slightly less than in the control (glucose, 204.5 ± 21.7 vs. 229 ± 19.6 mg/dl, IRI, 6.6 ± 1.3 vs. 9.3 ± 1.8 ng/ml mean ± SEM). At 3 min. after glucose administration, plasma glucose was higher (391.8 ± 25.6 vs. 371.8 ± 18.7 mg/dl) and IRI, lower (11.8 ± 2.1 vs. 18.2 ± 3.6 ng/ml) in the low VK group. The disappearance rate of plasma glucose in the low VK group at 5–10 min. was significantly less than in the control (6.7 ± 2.2 vs. 11.9 ± 1.8 mg/ dl/min.). Incremental IRI area at 0 to 5 min. in the low VK group is less than in the control (15.2 ± 4.4 vs. 25.0 ± 9.1 ng/ml/min.), but at 5–60 min. and 0–60 min., it was found to be significantly higher compared to the control (210.3 ± 55.2 vs. 32.5 ± 47.1 ng/ml/min. at 5–60 min.). Dietary low VK intake would thus appear to induce a tendency of poor early insulin response, and late hyperinsulinemia to the glucose load in rats.

Insulin responses during glucose tolerance tests in steers with increasing Wagyu genetic influence

1998 ◽  
Vol 78 (2) ◽  
pp. 233-235 ◽  
Author(s):  
P. S. Mir ◽  
G. J. Mears ◽  
C. M. Ross ◽  
S. D. Husar ◽  
W. M. Robertson ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Plasma Glucose ◽  
Insulin Response ◽  
Genetic Influence ◽  
Marbling Score ◽  
Intravenous Glucose ◽  
Post Infusion ◽  
Glucose Tolerance Tests ◽  
Intravenous Glucose Tolerance Tests ◽  
Insulin Responses

Intravenous glucose tolerance tests (IVGTT) were conducted in 18 steers with 0, 50 and 75% Wagyu genetic influence. Glucose clearances were similar for all steers. Plasma insulin concentrations (basal, 5 and 10 min post-infusion) were higher (P < 0.05) in 0% Wagyu steers (2.57, 7.36, 9.68 ng mL−1) relative to 50% Wagyu (1.17, 2.59, 5.34 ng mL−1) or 75% Wagyu (0.99, 2.78, 5.00 ng mL−1). A correlation coefficient of 0.71 (P = 0.005; n = 15) between marbling score of carcasses and plasma glucose concentration 90 min after glucose infusion suggests, possible associations among the propensity of cattle with Wagyu genetic influence to marble, mechanisms of glucose utilization and nature of the insulin response to circulating glucose. Key words: Plasma glucose, insulin, marbling, Wagyu

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