Ethanol-Induced Alteration in Membrane Phospholipid Composition: Possible Relationship to Development of Cellular Tolerance to Ethanol

Author(s):  
J. M. Littleton ◽  
S. J. Grieve ◽  
P. J. Griffiths ◽  
G. R. John
1994 ◽  
Vol 124 (3) ◽  
pp. 273-287 ◽  
Author(s):  
TP McGee ◽  
HB Skinner ◽  
EA Whitters ◽  
SA Henry ◽  
VA Bankaitis

SEC14p is required for protein transport from the yeast Golgi complex. We describe a quantitative analysis of yeast bulk membrane and Golgi membrane phospholipid composition under conditions where Golgi secretory function has been uncoupled from its usual SEC14p requirement. The data demonstrate that SEC14p specifically functions to maintain a reduced phosphatidylcholine content in Golgi membranes and indicate that overproduction of SEC14p markedly reduces the apparent rate of phosphatidylcholine biosynthesis via the CDP-choline pathway in vivo. We suggest that SEC14p serves as a sensor of Golgi membrane phospholipid composition through which the activity of the CDP-choline pathway in Golgi membranes is regulated such that a phosphatidylcholine content that is compatible with the essential secretory function of these membranes is maintained.


2021 ◽  
Vol 1863 (1) ◽  
pp. 183482
Author(s):  
Estelle Deschamps ◽  
Annick Schaumann ◽  
Isabelle Schmitz-Afonso ◽  
Carlos Afonso ◽  
Emmanuelle Dé ◽  
...  

2006 ◽  
Vol 50 (2) ◽  
pp. 95-102 ◽  
Author(s):  
Barbara J. Fuhrman ◽  
Maddalena Barba ◽  
Vittorio Krogh ◽  
Andrea Micheli ◽  
Valeria Pala ◽  
...  

1993 ◽  
Vol 67 (2) ◽  
pp. 132-137 ◽  
Author(s):  
Kazuhide Sumikawa ◽  
Zhouseng Mu ◽  
Tamotsu Inoue ◽  
Toshikazu Okochi ◽  
Takayoshi Yoshida ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document