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Mesenchymal stem cell (MSC) therapy for clinical diseases associated with inflammation and tissue damage
has become a progressive treatment strategy. MSCs have unique biological functions, such as homing, immune regulation,
and differentiation capabilities, which provide the prerequisites for treatment of clinical diseases. Oral diseases are often
associated with abnormal immune regulation and epithelial tissue damage. In this review, we summarize previous studies
that use MSC therapy to treat various oral inflammatory diseases, including oral ulceration, allergic diseases,
chemo/radiotherapy-induced oral mucositis, periodontitis, osteonecrosis of the jaw, Sjögren's syndrome (SS), among other
similar diseases. We highlight MSC treatment as a promising approach in the management of oral inflammatory diseases,
and discuss the obstacles that remain and must be overcome for MSC treatment to thrive in the future.