Decision letter for "Vitamin D and immune regulation: antibacterial, antiviral, anti‐inflammatory"

2020 ◽  
Keyword(s):  
Vitamin D ◽  
Immune Regulation ◽  
Anti Inflammatory

scholarly journals Vitamin D and immune regulation: antibacterial, antiviral, anti‐inflammatory

JBMR Plus ◽  
2020 ◽  
Author(s):  
Emma Bishop ◽  
Aiten Ismailova ◽  
Sarah K. Dimeloe ◽  
Martin Hewison ◽  
John H. White
Keyword(s):  
Vitamin D ◽  
Immune Regulation ◽  
Anti Inflammatory

scholarly journals Vitamin D-rich marine Inuit diet and markers of inflammation – a population-based survey in Greenland

2015 ◽  
Vol 4 ◽  
Author(s):  
L. K. Schæbel ◽  
E. C. Bonefeld-Jørgensen ◽  
P. Laurberg ◽  
H. Vestergaard ◽  
S. Andersen
Keyword(s):  
Vitamin D ◽  
Marine Mammals ◽  
Dietary Habits ◽  
High Sensitivity ◽  
Population Based ◽  
Mixed Diet ◽  
Markers Of Inflammation ◽  
Vitamin D Levels ◽  
Anti Inflammatory ◽  
Imported Foods

AbstractThe traditional Inuit diet in Greenland consists mainly of fish and marine mammals, rich in vitamin D. Vitamin D has anti-inflammatory capacity but markers of inflammation have been found to be high in Inuit living on a marine diet. Yet, the effect of vitamin D on inflammation in Inuit remains unsettled. This led us to investigate the association between vitamin D and markers of inflammation in a population with a high intake of a marine diet. We studied 535 Inuit and non-Inuit living in West and East Greenland. Information concerning dietary habits was obtained by interview-based FFQ. Blood samples were drawn for analysis of 25-hydroxyvitamin D, high-sensitivity C-reactive protein (hsCRP) and chitinase-3-like protein 1(YKL-40). Participants were divided into three groups based on degree of intake of the traditional Inuit diet. The diet groups (Inuit diet/mixed diet/imported foods) were associated with vitamin D levels in serum (74·2, 69·8 and 52·9 nm; P < 0·001), hsCRP (1·6, 1·4 and 1·3 mg/l; P = 0·002) and YKL-40 (130, 95 and 61 ng/ml; P < 0·001), respectively. YKL-40 level decreased with rising vitamin D level in Inuit (Inuit diet P = 0·002; mixed diet P = 0·011). YKL-40 was lower in groups with higher vitamin D levels after adjusting for other factors known to influence inflammation (P < 0·001). This was not seen for hsCRP. In conclusion, vitamin D and markers of inflammation vary in parallel with the intake of the marine Inuit diet. Vitamin D levels were inversely associated with YKL-40 levels, but no association with hsCRP was found. The hypothesised anti-inflammatory effect of vitamin D was not supported. Other factors in the marine diet may be speculated to influence inflammation.

scholarly journals Vitamin D as a Key Player in Modulating Rheumatoid Arthritis-derived Immune Response

2020 ◽  
Vol 14 (4) ◽  
pp. 2453-2465
Author(s):  
Ramadan Yahia ◽  
Shereen M. Mohammed ◽  
Manal M. Hassanien ◽  
Shabaan H. Ahmed ◽  
Helal F. Hetta
Keyword(s):  
Rheumatoid Arthritis ◽  
Vitamin D ◽  
Serum Level ◽  
Growth Function ◽  
Enzyme Linked Immunosorbent Assay ◽  
Reactive Protein ◽  
Vitamin D Levels ◽  
Systemic Inflammatory Disease ◽  
Anti Inflammatory ◽  
Factor Α

Rheumatoid arthritis (RA) is a systemic inflammatory disease with chronic nature of joints related to autoimmunity. Vitamin D was found to modulate cell growth, function of immune cells and anti-inflammatory action. The aims of that study were to investigate serum level of vitamin D and some cytokines and to identify the correlation between vitamin D and these cytokines in RA. Totally 40 RA patients without vitamin D supplement were involved in this study. Serum level of vitamin D, interleukin-6 (IL-6), IL-10, IL-35, C-reactive protein (CRP) and tumor necrosis factor α (TNF-α), all of them were measure in all patients by enzyme-linked immunosorbent assay (ELISA). Patients were classified according to Vitamin D levels into two groups; RA patients with Vit. D deficiency (n=25) and RA patients with Vit. D sufficiency (n=15). IL-6 was lower significantly (P = 0.03) in RA patients with Vit. D sufficiency than RA patients with Vit. D deficiency. IL-10 and IL-35 were higher significantly (P = 0.0234, P = 0.0356 respectively) in RA patients with Vit. D sufficiency than RA patients with Vit. D deficiency. Vit. D was significantly positively correlated with both IL-10 (r = 0.4516, P = 0.0034) and IL-35 (r = 0.3424, P = 0.0329) and negatively correlated with IL-6 (r = -0.3188, P = 0.0479). Sufficient serum level of Vit. D is correlated with higher level of anti-inflammatory cytokines (IL-10 and IL-35) and lower level of IL-6. This support the immunomodulatory effect of Vit. D in RA.

Does vitamin D prevent radiotherapy-induced toxicity?

2019 ◽  
Vol 44 (5) ◽  
pp. 575-577
Author(s):  
Yasemin Benderli Cihan
Keyword(s):  
Vitamin D ◽  
Immune Response ◽  
Cancer Treatment ◽  
Vitamin D3 ◽  
Vitamin D Metabolites ◽  
Cytokine Levels ◽  
Anti Inflammatory ◽  
Positive Effect

AbstractVitamin D is known as the bone hormone, it is also know that it has effects on cancer because of its anti-inflammatory and immunomodulatory characteristics and its effects on cytokine levels. It is seen that vitamin D use together with radiotherapy can have a positive effect on cancer treatment. It should be investigated whether toxicities due to radiation is prevented by vitamin D metabolites’ increasing the induction of immunomodulator cells and the capacities of immune response cells. Use of 1,25[OH]2 Vitamin D3 analogs as an adjuvant immunomodulator for patients receiving radiotherapy should be evaluated. There is a need for studies to be done in this regard.

scholarly journals Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research

2018 ◽  
Vol 19 (8) ◽  
pp. 2320 ◽  
Author(s):  
Greta Cermisoni ◽  
Alessandra Alteri ◽  
Laura Corti ◽  
Elisa Rabellotti ◽  
Enrico Papaleo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Endometrial Cancer ◽  
Inflammatory Responses ◽  
Active Form ◽  
Molecular Data ◽  
Secretory Phase ◽  
Endometrial Cells ◽  
Mrna And Protein Expression ◽  
Anti Inflammatory

Growing evidence supports a role of vitamin D (VD) in reproductive health. Vitamin D receptor (VDR) is expressed in the ovary, endometrium, and myometrium. The biological actions of VD in fertility and reproductive tissues have been investigated but mainly using animal models. Conversely, the molecular data addressing the mechanisms underlying VD action in the physiologic endometrium and in endometrial pathologies are still scant. Levels of VDR expression according to the menstrual cycle are yet to be definitively clarified, possibly being lower in the proliferative compared to the secretory phase and in mid-secretory compared to early secretory phase. Endometrial tissue also expresses the enzymes involved in the metabolism of VD. The potential anti-proliferative and anti-inflammatory effects of VD for the treatment of endometriosis have been investigated in recent years. Treatment of ectopic endometrial cells with 1,25(OH)2D3 could significantly reduce cytokine-mediated inflammatory responses. An alteration of VD metabolism in terms of increased 24-hydroxylase mRNA and protein expression has been demonstrated in endometrial cancer, albeit not consistently. The effect of the active form of the vitamin as an anti-proliferative, pro-apoptotic, anti-inflammatory, and differentiation-inducing agent has been demonstrated in various endometrial cancer cell lines.

scholarly journals Anti-Inflammatory Effects of Vitamin D on Human Immune Cells in the Context of Bacterial Infection

Nutrients ◽  
2016 ◽  
Vol 8 (12) ◽  
pp. 806 ◽  
Author(s):  
Edwin Hoe ◽  
Jordan Nathanielsz ◽  
Zheng Toh ◽  
Leena Spry ◽  
Rachel Marimla ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bacterial Infection ◽  
Immune Cells ◽  
Human Immune ◽  
Anti Inflammatory
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