Fluidity of Cell Membranes in the Presence of Some Drugs and Inhibitors

Photoreceptor disk membrane substructures by means of the complementary freeze-fracture-replica methods

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100081644 ◽

1978 ◽

Vol 36 (2) ◽

pp. 156-157

Author(s):

A. Tonosaki ◽

M. Yamasaki ◽

H. Washioka ◽

J. Mizoguchi

Keyword(s):

Cell Membranes ◽

Freeze Fracture ◽

Purple Membrane ◽

Remarkable Case ◽

Single Face ◽

Disk Membrane ◽

Associated Proteins ◽

Photoreceptor Membranes

A vertebrate disk membrane is composed of 40 % lipids and 60 % proteins. Its fracture faces have been classed into the plasmic (PF) and exoplasmic faces (EF), complementary with each other, like those of most other types of cell membranes. The hypothesis assuming the PF particles as representing membrane-associated proteins has been challenged by serious questions if they in fact emerge from the crystalline formation or decoration effects during freezing and shadowing processes. This problem seems to be yet unanswered, despite the remarkable case of the purple membrane of Halobacterium, partly because most observations have been made on the replicas from a single face of specimen, and partly because, in the case of photoreceptor membranes, the conformation of a rhodopsin and its relatives remains yet uncertain. The former defect seems to be partially fulfilled with complementary replica methods.

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Introduction to Cell Membranes at Molecular Resolution

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100070217 ◽

1978 ◽

Vol 36 (3) ◽

pp. 497-502

Author(s):

R.J. Barrnett

Keyword(s):

Cell Membranes ◽

International Federation ◽

Mountain Range ◽

Cellular Membranes ◽

Short History ◽

Biological Organization ◽

Macromolecular Assemblies ◽

The Past

This subject, is like observing the panorama of a mountain range, magnificent towering peaks, but it doesn't take much duration of observation to recognize that they are still in the process of formation. The mountains consist of approaches, materials and methods and the rocky substance of information has accumulated to such a degree that I find myself concentrating on the foothills in the foreground in order to keep up with the advance; the edifices behind form a wonderous, substantive background. It's a short history for such an accumulation and much of it has been moved by the members of the societies that make up this International Federation. My panel of speakers are here to provide what we hope is an interesting scientific fare, based on the fact that there is a continuum of biological organization from biochemical molecules through macromolecular assemblies and cellular membranes to the cell itself. Indeed, this fact explains the whole range of towering peaks that have emerged progressively during the past 25 years.

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664: CXCL12/CXCR4 Trans-Activation of HER2 in Lipid Rafts of Prostate Cancer Cell Membranes Promotes Bone Metastasis

The Journal of Urology ◽

10.1016/s0022-5347(18)30904-2 ◽

2007 ◽

Vol 177 (4S) ◽

pp. 223-223

Author(s):

Sreenivasa R. Chinni ◽

Hamilto Yamamoto ◽

Zhong Dong ◽

Aaron Sabbota ◽

Sanaa Nabha ◽

...

Keyword(s):

Prostate Cancer ◽

Bone Metastasis ◽

Lipid Rafts ◽

Cancer Cell ◽

Cell Membranes ◽

Prostate Cancer Cell

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Adenosine triphosphatase and active cation transport in red blood cell membranes

Archives of Internal Medicine ◽

10.1001/archinte.129.2.241 ◽

1972 ◽

Vol 129 (2) ◽

pp. 241-247 ◽

Cited By ~ 3

Author(s):

P. B. Dunham

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Adenosine Triphosphatase ◽

Cell Membranes ◽

Cation Transport ◽

Red Blood Cell Membranes

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Melatonin actions in the heart; more than a hormone

Melatonin Research ◽

10.32794/mr11250002 ◽

2018 ◽

Vol 1 (1) ◽

pp. 21-26 ◽

Cited By ~ 9

Author(s):

Darío Acuña-Castroviejo ◽

Maria T Noguiera-Navarro ◽

Russel J Reiter ◽

Germaine Escames

Keyword(s):

Cell Membranes ◽

Myocardial Cell ◽

Rat Tissues ◽

Dependent Manner ◽

Broad Distribution ◽

Multiple Organs ◽

High Doses ◽

Extrapineal Melatonin ◽

Dose Dependent ◽

Different Doses

Due to the broad distribution of extrapineal melatonin in multiple organs and tissues, we analyzed the presence and subcellular distribution of the indoleamine in the heart of rats. Groups of sham-operated and pinealectomized rats were sacrificed at different times along the day, and the melatonin content in myocardial cell membranes, cytosol, nuclei and mitochondria, were measured. Other groups of control animals were treated with different doses of melatonin to monitor its intracellular distribution. The results show that melatonin levels in the cell membrane, cytosol, nucleus, and mitochondria vary along the day, without showing a circadian rhythm. Pinealectomized animals trend to show higher values than sham-operated rats. Exogenous administration of melatonin yields its accumulation in a dose-dependent manner in all subcellular compartments analyzed, with maximal concentrations found in cell membranes at doses of 200 mg/kg bw melatonin. Interestingly, at dose of 40 mg/kg b.w, maximal concentration of melatonin was reached in the nucleus and mitochondrion. The results confirm previous data in other rat tissues including liver and brain, and support that melatonin is not uniformly distributed in the cell, whereas high doses of melatonin may be required for therapeutic purposes.

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